DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and znf977

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_021331166.1	Gene:	znf977 / 103910561	ZFINID:	ZDB-GENE-110913-138	Length:	765	Species:	Danio rerio

Alignment Length:	407	Identity:	147/407 - (36%)
Similarity:	196/407 - (48%)	Gaps:	55/407 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 NAGPANTNANEGGAGANGSGGVGGATGASVGVGSVGVTSGGRTGNGPGRPHKN---KPHSDLRLF 329
            :.|......|:.|...|.|..:........|......|..||:.|...  |.|   |.|:..:.|
Zfish    60 HTGEQPFTCNQCGKSFNRSSTLNKHMKIHTGEKPFICTQCGRSFNRSS--HLNDHMKIHTGEKPF 122

  Fly   330 KCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSF 394
            .|..|||.|.|.|.|.:|.||||..:||.|::|||.|.|.|||.:|::||..||||||..|.:||
Zfish   123 TCTQCGKSFSQSSYLNKHMRIHTREKPFTCTQCGKSFNQSSHLNKHMKIHTGEKPFTCTQCGKSF 187

  Fly   395 RQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGP----------H 449
            .|.:.||.|::||:|||||.|.:|||.|||.:.||:|:|||....|....:.|.          |
Zfish   188 NQLSHLNSHMKIHTGEKPFTCTQCGKSFRQSSSLNRHMRTHTGEKPFTCTQCGKSFSQSSSLNLH 252

  Fly   450 PTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHI 514
            ..:...:.||         .....|..:....|.       .:|                |..|.
Zfish   253 MRIHTGEKPF---------TCTQCGKSFSQSSSL-------NLH----------------VRIHT 285

  Fly   515 GVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEK 579
            |.:|      ..||.|.|.|.|.:.|..|..||...:|:.||:|||.|.|.|:|..|:.|||.:|
Zfish   286 GEKP------FTCPHCGKSFNQSSHLNCHMKIHTGEKPFTCPQCGKSFSQSSNLNCHMTIHTGQK 344

  Fly   580 PFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNC 644
            ||.|..|.:.|...:.|:||:||||||||:.|.||||.|...:.|.||.|.|.|::||.|  ..|
Zfish   345 PFTCTQCGKSFTCSSRLHQHMRIHTGEKPFTCTQCGKSFTCSSRLHQHMRIHTGEKPFSC--TQC 407

  Fly   645 RRRFATENEVTKHIDNH 661
            .:.|:..:.:.:|:..|
Zfish   408 GKSFSQSSHLNQHMRIH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	119/317 (38%)
		zf-C2H2	357..379	CDD:278523	11/21 (52%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	14/24 (58%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	11/19 (58%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		zf-C2H2	553..575	CDD:278523	10/21 (48%)
		C2H2 Zn finger	555..575	CDD:275368	10/19 (53%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	596..620	CDD:290200	17/23 (74%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		zf-H2C2_2	624..650	CDD:290200	11/25 (44%)
		C2H2 Zn finger	639..661	CDD:275368	4/21 (19%)
znf977	XP_021331166.1	COG5048	8..415	CDD:227381	145/396 (37%)
		C2H2 Zn finger	12..32	CDD:275368
		C2H2 Zn finger	40..60	CDD:275368	147/407 (36%)
		C2H2 Zn finger	68..88	CDD:275368	4/19 (21%)
		C2H2 Zn finger	96..116	CDD:275368	7/21 (33%)
		C2H2 Zn finger	124..144	CDD:275368	10/19 (53%)
		C2H2 Zn finger	152..172	CDD:275368	10/19 (53%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		C2H2 Zn finger	208..228	CDD:275368	11/19 (58%)
		C2H2 Zn finger	236..256	CDD:275368	2/19 (11%)
		C2H2 Zn finger	264..284	CDD:275368	4/42 (10%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		C2H2 Zn finger	320..340	CDD:275368	10/19 (53%)
		COG5048	343..756	CDD:227381	36/84 (43%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	10/19 (53%)
		C2H2 Zn finger	404..424	CDD:275368	4/21 (19%)
		C2H2 Zn finger	432..452	CDD:275368
		C2H2 Zn finger	460..480	CDD:275368
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	544..564	CDD:275368
		C2H2 Zn finger	572..592	CDD:275368
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		C2H2 Zn finger	656..676	CDD:275368
		C2H2 Zn finger	684..704	CDD:275368
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910