DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and si:zfos-932h1.3

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_021330860.1	Gene:	si:zfos-932h1.3 / 100329491	ZFINID:	ZDB-GENE-141222-4	Length:	949	Species:	Danio rerio

Alignment Length:	836	Identity:	188/836 - (22%)
Similarity:	262/836 - (31%)	Gaps:	309/836 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SASFAACIAAGLKVPRQIMYCITQDTGQPYVLYKDSQDAERNPGAI-----------GATPAQWG 59
            |.|...||.:.|.||.....|:   :.:|.:|:.       .|.|:           ..|..:..
Zfish   224 SRSSGECIVSSLSVPPSARMCV---SSEPLLLHV-------QPAAVTILSSDTIIVTDYTEVELT 278

  Fly    60 SEMYPNIQQQ----AQQHLTAQQQQ-----QQQQQNAAQAAAQAAAVAAAAGQPQSPPGGGQEAR 115
            .|:...:|::    .:|..||:|..     ..||.|.                  .||...|...
Zfish   279 EELMEPMQEEESGGEEQEPTAEQHSCTNPPPPQQNNT------------------DPPPPQQNNT 325

  Fly   116 D-----NGSGDGRQQQVSPSSSPYPSVQQQQRANGAGDEDPMNHQLANQQNPAPNQN-------- 167
            |     ..:.|....|.:.:..|.|    ||     .:.||...|..|...|.|.||
Zfish   326 DPPPPQQNNTDPPPPQQNNTDPPPP----QQ-----NNTDPPPPQQNNTDPPPPQQNNTDPPPPQ 381

  Fly   168 QSSNDPQHSGSNAGESGNPHVQQNGGPQNDPGNSFRTPDYYDPRHAA---PQ---------GGML 220
            |::.||.....|  .:..|.:|||......|..:...|    |.|.|   ||         .|..
Zfish   382 QNNTDPPPPQQN--NTDPPPLQQNNNDPPPPQQNNTDP----PPHCAQHPPQEHTHITQKLPGQT 440

  Fly   221 ----APPG-----FPPLHYLNKGVLPMEQSGGG---------GGAGGGEAYALPEMLPAQQNGQQ 267
                .|||     ..||...:....|:.:.|.|         |..|||.|..|....|..|:.:.
Zfish   441 DITQKPPGQTDITQKPLGQTDITQKPLGRRGRGRQRKSTEPMGKTGGGAAEELRAGAPHGQDREG 505

  Fly   268 NAGPANTNANEGGAGAN--------GSGGVGGATGASVGVGSVG--------------------- 303
            .|.||...|....:.|:        .:..|.....|.......|
Zfish   506 CADPAAPLATSEPSSASCRTRRSSKAAPPVAANPRARYACDICGRKFTRRSDVQRHQLTHTGERP 570

  Fly   304 -------------------------------------------VTSGGRTGNGPGRPH------- 318
                                                       :|:..:..:|...||
Zfish   571 FHCGQCQKTFQHSWDLSKHCRKQHGEARFSCSVCQSDFTNLRLLTAHHKQSHGGAVPHYCSICGE 635

  Fly   319 ----------KNKPHSDLRLFKCLTCG----------------------------KDFKQKSTLL 345
                      ..:.||..:|::|..||                            |.|.:.|.:.
Zfish   636 TAGSPSALAQHRRSHSAAQLYRCPQCGEAFDTLLQRSLHRQSHRPRQRHQCPQCPKSFTRSSDVR 700

  Fly   346 QHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTCPYCSRSFRQRAILNQHIRIHSGE 410
            :|...|:..||..|:.|||.|..:|.|.:|...|..|:|..|..|.:||.|.:||.:|.|:|:||
Zfish   701 RHQLSHSGERPHHCTVCGKSFGLRSGLLKHQATHTGERPHCCTVCGKSFTQLSILLRHQRMHTGE 765

  Fly   411 KPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNGPHPTLWPSDVPFPGEDNDTKGDIAGTGG 475
            :|:.|.:|||.|.....|.:|.:||.:..||
Zfish   766 RPYLCSQCGKRFLSLGELLKHDKTHAEDRPH---------------------------------- 796

  Fly   476 GYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVLQHIGVRPANMPLYVRCPICDKEFKQKTTL 540
                                                              .||.|.|.||.|..|
Zfish   797 --------------------------------------------------TCPQCPKSFKYKRAL 811

  Fly   541 LQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTG 605
            .:|...|...|||||..|||.|.:...|.:|..|||.|:||.|.:|.|.|...|.|..|.|.|||
Zfish   812 QEHMLAHTGVRPYPCRYCGKMFAKPFALNRHHLIHTGERPFSCAHCERTFLTSTELALHERTHTG 876

  Fly   606 EKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATENEVTKHIDNH 661
            |:|:.|..|.:.||..:.|.:|.|||.|.||..|..  |.:.:::.:.:..|...|
Zfish   877 ERPFPCTACPRRFRSSSELARHRRTHSGPRPHACRY--CPKAYSSASRLRSHTRTH 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	7/47 (15%)
		COG5048	355..666	CDD:227381	93/307 (30%)
		zf-C2H2	357..379	CDD:278523	8/21 (38%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		zf-H2C2_2	371..396	CDD:290200	9/24 (38%)
		C2H2 Zn finger	387..407	CDD:275368	9/19 (47%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	9/19 (47%)
		zf-C2H2	553..575	CDD:278523	9/21 (43%)
		C2H2 Zn finger	555..575	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	596..620	CDD:290200	11/23 (48%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	10/25 (40%)
		C2H2 Zn finger	639..661	CDD:275368	3/21 (14%)
si:zfos-932h1.3	XP_021330860.1	TIN2_N	23..199	CDD:240667
		PAT1	<307..>439	CDD:330585	36/164 (22%)
		C2H2 Zn finger	545..565	CDD:275368	1/19 (5%)
		C2H2 Zn finger	573..593	CDD:275368	0/19 (0%)
		C2H2 Zn finger	601..619	CDD:275368	1/17 (6%)
		C2H2 Zn finger	658..678	CDD:275368	3/19 (16%)
		COG5048	<679..861	CDD:227381	72/265 (27%)
		C2H2 Zn finger	686..706	CDD:275368	4/19 (21%)
		C2H2 Zn finger	714..734	CDD:275368	8/19 (42%)
		C2H2 Zn finger	742..762	CDD:275368	9/19 (47%)
		C2H2 Zn finger	770..790	CDD:275368	7/19 (37%)
		C2H2 Zn finger	798..818	CDD:275368	9/19 (47%)
		C2H2 Zn finger	826..846	CDD:275368	7/19 (37%)
		C2H2 Zn finger	854..874	CDD:275368	8/19 (42%)
		zf-H2C2_2	866..891	CDD:316026	11/24 (46%)
		C2H2 Zn finger	882..902	CDD:275368	7/19 (37%)
		zf-H2C2_2	894..919	CDD:316026	10/26 (38%)
		C2H2 Zn finger	910..930	CDD:275368	3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910