DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF729

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001229609.1	Gene:	ZNF729 / 100287226	HGNCID:	32464	Length:	1252	Species:	Homo sapiens

Alignment Length:	341	Identity:	125/341 - (36%)
Similarity:	172/341 - (50%)	Gaps:	42/341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANEKPFTC 387
            |:..:.:||..|||.|...|||::|..|||..:|:.|.||||.|||.||||:|..||..|||:.|
Human   426 HTGKKPYKCEECGKAFNSSSTLMKHKIIHTGEKPYKCEECGKAFRQSSHLTRHKAIHTGEKPYKC 490

  Fly   388 PYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPH------LIFKN 446
            ..|.::|...:.|.:|..||:|:||:.|.||||.|.|.:.|..|...|....|:      ..||
Human   491 EECGKAFNHFSDLRRHKIIHTGKKPYKCEECGKAFSQSSTLRNHQIIHTGEKPYKCEECGKAFK- 554

  Fly   447 GPHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGKGQKILPEVL 511
                  |.|.:        |...:..||    ::..:....|....|:.:..|    .|::
Human   555 ------WSSKL--------TVHKVIHTG----EKPCKCEECGKAFKHFSALRK----HKVI---- 593

  Fly   512 QHIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHT 576
             |     ....|| :|..|.|.|...:.|.:|..||...:||.|.||||.|||.||||:|..|||
Human   594 -H-----TREKLY-KCEECGKAFNNSSILAKHKIIHTGKKPYKCEECGKAFRQSSHLTRHKAIHT 651

  Fly   577 NEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQHTRTHQGDRPFCCPM 641
            .|||:.|..|.:.|...:.|.:|..||||:|||||.:|||.|...:.|.:|...|.|::|:.|
Human   652 GEKPYKCEECGKAFSHFSALRRHKIIHTGKKPYKCEECGKAFSHFSALRRHKIIHTGEKPYKC-- 714

  Fly   642 PNCRRRFATENEVTKH 657
            ..|.:.|...:::|.|
Human   715 EECGKAFKWSSKLTVH 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	111/309 (36%)
		zf-C2H2	357..379	CDD:278523	13/21 (62%)
		C2H2 Zn finger	359..379	CDD:275368	13/19 (68%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	14/21 (67%)
		C2H2 Zn finger	555..575	CDD:275368	13/19 (68%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	15/23 (65%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..650	CDD:290200	8/25 (32%)
		C2H2 Zn finger	639..661	CDD:275368	5/19 (26%)
ZNF729	NP_001229609.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	182..202	CDD:275368
		C2H2 Zn finger	210..230	CDD:275368
		C2H2 Zn finger	239..258	CDD:275368
		COG5048	262..666	CDD:227381	99/273 (36%)
		C2H2 Zn finger	266..286	CDD:275368
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	351..370	CDD:275368
		zf-H2C2_2	363..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368	125/341 (37%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		C2H2 Zn finger	462..482	CDD:275368	13/19 (68%)
		zf-H2C2_2	474..499	CDD:290200	12/24 (50%)
		C2H2 Zn finger	490..510	CDD:275368	5/19 (26%)
		zf-H2C2_2	502..527	CDD:290200	13/24 (54%)
		C2H2 Zn finger	518..538	CDD:275368	9/19 (47%)
		zf-H2C2_2	531..554	CDD:290200	4/22 (18%)
		C2H2 Zn finger	546..566	CDD:275368	5/34 (15%)
		C2H2 Zn finger	574..594	CDD:275368	4/28 (14%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		COG5048	625..1123	CDD:227381	49/108 (45%)
		C2H2 Zn finger	630..650	CDD:275368	13/19 (68%)
		zf-H2C2_2	642..667	CDD:290200	13/24 (54%)
		C2H2 Zn finger	658..678	CDD:275368	5/19 (26%)
		zf-H2C2_2	670..695	CDD:290200	15/24 (63%)
		C2H2 Zn finger	686..706	CDD:275368	7/19 (37%)
		zf-H2C2_2	698..722	CDD:290200	7/25 (28%)
		C2H2 Zn finger	714..734	CDD:275368	5/19 (26%)
		C2H2 Zn finger	742..762	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368
		C2H2 Zn finger	854..874	CDD:275368
		zf-H2C2_2	866..890	CDD:290200
		C2H2 Zn finger	882..902	CDD:275368
		C2H2 Zn finger	910..930	CDD:275368
		C2H2 Zn finger	938..958	CDD:275368
		C2H2 Zn finger	966..986	CDD:275368
		zf-H2C2_2	978..1003	CDD:290200
		C2H2 Zn finger	994..1014	CDD:275368
		C2H2 Zn finger	1022..1042	CDD:275368
		zf-H2C2_2	1034..1058	CDD:290200
		C2H2 Zn finger	1050..1070	CDD:275368
		C2H2 Zn finger	1078..1098	CDD:275368
		C2H2 Zn finger	1106..1126	CDD:275368
		C2H2 Zn finger	1134..1154	CDD:275368
		C2H2 Zn finger	1162..1182	CDD:275368
		C2H2 Zn finger	1190..1210	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000