DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jim and ZNF737

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_005259754.1	Gene:	ZNF737 / 100129842	HGNCID:	32468	Length:	551	Species:	Homo sapiens

Alignment Length:	369	Identity:	131/369 - (35%)
Similarity:	173/369 - (46%)	Gaps:	61/369 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 HKNKPHSDLRLFKCLTCGKDFKQKSTLLQHDRIHTDARPFPCSECGKRFRQQSHLTQHLRIHANE 382
            ||.: |:..:.|||:.|||.|.|.|||..|.:|||..:||.|.||||.|...||||.|.|||..|
Human   163 HKIR-HTGKKPFKCIECGKAFNQSSTLTTHKKIHTGEKPFKCEECGKAFNWSSHLTTHKRIHTGE 226

  Fly   383 KPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPH------ 441
            |.:.|..|.::|.:.:.|..|..|||||||:.|.||||.|::.:.|..|...|....|:
Human   227 KRYKCEDCGKAFSRFSYLTAHKIIHSGEKPYKCEECGKAFKRSSNLTTHKIIHTGEKPYKCEECG 291

  Fly   442 LIFKNG----PHPTLWPSDVPFPGEDNDTKGDIAGTGGGYHDEDSQGTPDGSGGMHYPSYFKDGK 502
            ..||..    .|..:...:.|:..|:                                    .||
Human   292 KAFKRSSILTAHKIIHSGEKPYKCEE------------------------------------CGK 320

  Fly   503 GQKILPEVLQ-----HIGVRPANMPLYVRCPICDKEFKQKTTLLQHGCIHIESRPYPCPECGKRF 562
            ..| .|.||.     |.|.:|      .:|..|.:.||..::|..|..||...:||.|.||||.|
Human   321 AFK-HPSVLTTHKRIHTGEKP------YKCEECGRAFKYFSSLTTHKIIHSGEKPYKCEECGKAF 378

  Fly   563 RQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRIHTGEKPYKCGQCGKDFRQKAILDQH 627
            ...||||.|.||||.|||:.|..|...|:..:.|..|..||||::|:||.:|||.|:..:||..|
Human   379 NWSSHLTTHKRIHTGEKPYKCEECGEAFKYSSSLTTHKIIHTGQQPFKCEECGKAFKCFSILTTH 443

  Fly   628 TRTHQGDRPFCCPMPNCRRRFATENEVTKHIDNHMNPNTTKVRR 671
            .|.|.|::|:.|  ..|.:.|.:.:.:|.|...|......|..|
Human   444 KRIHTGEKPYKC--EECGKAFNSSSHLTAHKRIHTGEKPYKCER 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		COG5048	355..666	CDD:227381	111/325 (34%)
		zf-C2H2	357..379	CDD:278523	13/21 (62%)
		C2H2 Zn finger	359..379	CDD:275368	12/19 (63%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		zf-C2H2	553..575	CDD:278523	13/21 (62%)
		C2H2 Zn finger	555..575	CDD:275368	12/19 (63%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..620	CDD:290200	13/23 (57%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	624..650	CDD:290200	9/25 (36%)
		C2H2 Zn finger	639..661	CDD:275368	5/21 (24%)
ZNF737	XP_005259754.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		COG5048	143..528	CDD:227381	131/369 (36%)
		zf-H2C2_2	159..184	CDD:290200	10/21 (48%)
		C2H2 Zn finger	175..195	CDD:275368	10/19 (53%)
		zf-H2C2_2	188..211	CDD:290200	12/22 (55%)
		C2H2 Zn finger	203..223	CDD:275368	12/19 (63%)
		zf-H2C2_2	215..240	CDD:290200	12/24 (50%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		zf-H2C2_2	243..268	CDD:290200	15/24 (63%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		zf-H2C2_2	271..296	CDD:290200	5/24 (21%)
		C2H2 Zn finger	287..307	CDD:275368	3/19 (16%)
		zf-H2C2_2	300..324	CDD:290200	6/60 (10%)
		C2H2 Zn finger	315..335	CDD:275368	7/56 (13%)
		zf-H2C2_2	328..352	CDD:290200	7/29 (24%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		zf-H2C2_2	355..379	CDD:290200	11/23 (48%)
		C2H2 Zn finger	371..391	CDD:275368	12/19 (63%)
		zf-H2C2_2	383..408	CDD:290200	14/24 (58%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		zf-H2C2_2	440..464	CDD:290200	9/25 (36%)
		C2H2 Zn finger	455..475	CDD:275368	5/21 (24%)
		zf-H2C2_2	467..492	CDD:290200	5/19 (26%)
		C2H2 Zn finger	483..503	CDD:275368	1/3 (33%)
		zf-H2C2_2	496..520	CDD:290200
		C2H2 Zn finger	511..529	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010