DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jim and znf865

DIOPT Version :9

Sequence 1:	NP_001262221.1	Gene:	jim / 43924	FlyBaseID:	FBgn0027339	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001076544.1	Gene:	znf865 / 100034513	ZFINID:	ZDB-GENE-060503-896	Length:	1506	Species:	Danio rerio

Alignment Length:	1346	Identity:	287/1346 - (21%)
Similarity:	396/1346 - (29%)	Gaps:	580/1346 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GSEMYPNIQQQAQ-QHLTAQQQQQQQQQNA-----------------AQAAAQAAAVAAAAGQPQ 105
            |.|.....|||.| ||....|||||||..|                 :.|.|.::::.|....|
Zfish    27 GLERQLQHQQQVQLQHQQQLQQQQQQQSEASSGLLSGLGLGSLQGSRSNAFADSSSLFAKMSAP- 90

  Fly   106 SPPGGGQEARDNGSGDGRQQQVSPSS-------SPYP-----------SVQQQQRANGAGDED-- 150
             ||...|:.:.:.|...|:.....||       |.||           ::.|:|..:|.|..|
Zfish    91 -PPPLPQQTQSSSSQSTRKSSKMSSSSGSGSSASGYPQFLRTFHPAEAALAQEQLHSGMGRFDFA 154

  Fly   151 ----------------------PMNHQLA-NQQNPAPNQNQ---------SSNDPQHSGSNAG-- 181
                                  |::..|: .|.:|.|:.:.         |:|.|..|.|.||
Zfish   155 GGSTGGGSGVIGGVVTSAPPPPPLHPGLSVPQPSPGPSSSSPSPSSSTTTSNNPPSSSSSVAGLV 219

  Fly   182 -----------------------ESGNPH--------VQQNGGPQNDPG---------------- 199
                                   .||.|.        |||  ||.|..|
Zfish   220 GAQSDARSLHQQFSCMLAANQYLFSGVPTNASLEQFLVQQ--GPHNHLGLADSNTGLAPPPALHP 282

  Fly   200 ---NSFRTPD---------------------YYDPRHAAPQ----GG-----------------M 219
               :...||.                     .:.|.|.|||    ||                 |
Zfish   283 SHTHGHPTPQPQQQQQQLPPHALSHPHSHAHPHHPLHPAPQPSPLGGFDFQGIPVLSSNQLASLM 347

  Fly   220 LAPPGFP---PLHYLNKGVLPMEQ--------SGGGGGAGGGEAYALPEMLPAQQNGQQNAGPAN 273
            ....|.|   |||.    .:|.:.        :||.||:|.....|:...|| |:....::..:.
Zfish   348 QQEAGLPLPLPLHL----SVPKDDGKGDSGSGAGGSGGSGSRRKKAMAGYLP-QRKTDGSSSNST 407

  Fly   274 TNANEGGAGANGSGGVGGATGASVGVGSVGV---------------TSGGRTGNGPGRPHKN--- 320
            ::||..|:||:|..|..|..|...|||..|:               :|...:.:....|..|
Zfish   408 SSANCHGSGAHGHDGSSGLVGGGGGVGMRGLGGDPSSILSSSTPSSSSSTVSSSSSSAPSSNSAS 472

  Fly   321 ----------KPHSDL------------RLFKCLTCGKDFKQKSTLLQHDRIHTDA--------- 354
                      ||.:..            .||.|..|||.|....||.:|.|.|.|.
Zfish   473 VLVSNISQNPKPENQQSMTPNITQTEQEALFHCGECGKSFGHLPTLRRHIRCHEDGGGQNSSTNT 537

  Fly   355 ------------------------RPFP-------------CSECGKRFRQQSHLTQHLRIHANE 382
                                    .|.|             |:||||.|:::.||.||..||:.:
Zfish   538 NHQHQSDLPHSTQDGISQNAHHHENPDPMSSTCSSPDKSYCCNECGKGFKKRGHLLQHGVIHSGD 602

  Fly   383 KPFTCPYCSRSFRQRAILNQHIRIHSGEKPFACPECGKHFRQKAILNQHVRTHQDVSPHLIFKNG 447
            :|:.|..|.|||.:|..|.:|.:||. |||:.||.||:.||:...|..|..:.....|....::.
Zfish   603 RPYACTVCERSFNRRESLTRHEKIHE-EKPYRCPACGRCFRESTSLLNHAASGNCGKPGRRSRSS 666

  Fly   448 PHPTLWPSD----VPFP-GEDNDTKGDIA------GTGG-------------------------- 475
            ...::...|    ..|| |:..||| |:.      .|.|
Zfish   667 DGSSIGSVDGKVETDFPGGQITDTK-DLVFCKNEDSTAGMSCDSLYSQARNANQNPIGKPKEEYN 730

  Fly   476 ----------GYHDED---SQGTPDGSGG-----------------------------------M 492
                      .|..:|   .||.|....|                                   .
Zfish   731 PEYSRDPYQTSYRVDDYRRQQGNPASYSGDSCSNSMSSPALRKAPLAPTLHPHPQNQTHHHQPQS 795

  Fly   493 HYP--SYFKDGKGQ---------------KILPEVLQHIGVRP---------------------- 518
            |.|  |...|.:.:               .:||..:.:.|.|.
Zfish   796 HLPLSSLLDDSEDEVTSSAMSAIAAAAAASVLPAEMNNNGGREERRDIIGGLLGGLGFGSMGASS 860

  Fly   519 --------------------------------ANMP-------------LYVRCPICDKEFKQKT 538
                                            ||.|             ...|.|....|..::.
Zfish   861 STSAGNGGNEECLSGSMIPLSHPTQQQPNSQNANNPNAKPKRPRKPRQKREPRPPGAPGEVVKRR 925

  Fly   539 TLLQHGCIHIES-RPYPCPECGKRFRQQSHLTQHLRIHTNEKPFGCMYCPRFFRQRTILNQHLRI 602
            ...|.|.....| |||.|..||:.|.::..|.:|.|:||.||||.|..|.:.||:...|.:|..:
Zfish   926 RSSQGGAAGDGSDRPYLCTVCGRGFSRRETLRRHERVHTGEKPFHCDICGKDFREPFHLTKHQTV 990

  Fly   603 HTGEKPYKCGQCGKDFRQKAILDQHTRTH-QGDRPFCCPMPNCRRRFATENEVTKHIDNHMNPNT 666
            |:|||.|||..|||||.....|.:|.:.| :||
Zfish   991 HSGEKNYKCTLCGKDFGYAQSLKRHEKLHLRGD-------------------------------- 1023

  Fly   667 TKVRRQQQQQHQQQQQQQQQQQQQQQQQNNNAVAQVANHLMNDAKSLAAQQFLNNNNPSAV---- 727
            .|.||.:.:....|.....|:|..|..||                        |.:||.|.
Zfish  1024 FKPRRSKTKSAANQGVPANQEQTDQTNQN------------------------NQSNPGAYYSYS 1064

  Fly   728 DNKANILPVRSIASNAAAAAVVQQSVVKNELYFPQCYGPPFQHPFQ--AQQQQAQQPSVAHANGG 790
            .:|..       .|||:.:   .|...|  ||..:.....|:|.|.  |..|      ..|.:||
Zfish  1065 QDKVQ-------GSNASTS---NQPPPK--LYTCEICWKSFRHHFHLTAHHQ------AIHEHGG 1111

  Fly   791 PTPPVTVTVANSVA-SGVVVQQNASASVVAQXHPTTAATGAQQQQPSAPQQQHHPPPPPPTSTAH 854
            ...........:.: |..:.:...|...:.:..|||..||...                 ..||.
Zfish  1112 EKLFSCEVCGKAFSYSNSLTRHRLSQHGLTRAGPTTQPTGNDS-----------------IGTAS 1159

  Fly   855 HIASAAAAVTAVTPSSAHASPVAAPQTV-----TLSITLPPPPAS-----HTVHPGH------PG 903
            .::.:.||..|:    .|.||.:....|     |::.|..|.||.     :|...||      ..
Zfish  1160 SVSESEAATNAL----LHISPESGSHGVQQPHSTIAHTQHPQPAGYSPLFYTPESGHHSSNQVTS 1220

  Fly   904 HPGHPGVANGAAPP-----------------PPTLSHAIPIHPHIH 932
            ||.|...:|....|                 |....|:.|  ||||
Zfish  1221 HPQHLHYSNPTMGPLQLQQPISGKQLIYSGVPSNTLHSTP--PHIH 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jim	NP_001262221.1	C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		COG5048	355..666	CDD:227381	109/494 (22%)
		zf-C2H2	357..379	CDD:278523	11/34 (32%)
		C2H2 Zn finger	359..379	CDD:275368	10/19 (53%)
		zf-H2C2_2	371..396	CDD:290200	12/24 (50%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	4/19 (21%)
		zf-C2H2	553..575	CDD:278523	8/21 (38%)
		C2H2 Zn finger	555..575	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..620	CDD:290200	14/23 (61%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..650	CDD:290200	5/26 (19%)
		C2H2 Zn finger	639..661	CDD:275368	0/21 (0%)
znf865	NP_001076544.1	C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		C2H2 Zn finger	579..599	CDD:275368	10/19 (53%)
		C2H2 Zn finger	607..627	CDD:275368	8/19 (42%)
		C2H2 Zn finger	634..650	CDD:275368	7/15 (47%)
		C2H2 Zn finger	943..963	CDD:275368	7/19 (37%)
		zf-H2C2_2	956..978	CDD:290200	11/21 (52%)
		C2H2 Zn finger	971..991	CDD:275368	6/19 (32%)
		zf-H2C2_2	983..1008	CDD:290200	14/24 (58%)
		C2H2 Zn finger	999..1019	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1086..1109	CDD:275368	6/28 (21%)
		C2H2 Zn finger	1117..1135	CDD:275368	1/17 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3783
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960