DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and CNTNAP1

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_003623.1 Gene:CNTNAP1 / 8506 HGNCID:8011 Length:1384 Species:Homo sapiens


Alignment Length:1210 Identity:274/1210 - (22%)
Similarity:464/1210 - (38%) Gaps:240/1210 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   433 NVNEGCSDMCESRHNLCF-VGSRCI-------NHYG--GISCDCFGTHYEGEHCDIYTATIITLR 487
            ||||.    ...||:|.| ..:|.|       |..|  |:....:|..|:        |.|:...
Human   126 NVNES----AVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYK--------ADILYFD 178

  Fly   488 GASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFG 552
            |...:|||......|  |.....:..|:|...|..|.:|.|  .:..|:...::...:.:.|..|
Human   179 GDDAISYRFPRGVSR--SLWDVFAFSFKTEEKDGLLLHAEG--AQGDYVTLELEGAHLLLHMSLG 239

  Fly   553 DNVMST-----------VLTDDLTRGYWHNLTILHEQRTVSIILD--QQQKVLELPATASGN--- 601
            .:.:..           ||.|.    :||.:.:....|.|:..||  .|:.:|      :|:   
Human   240 SSPIQPRPGHTTVSAGGVLNDQ----HWHYVRVDRFGRDVNFTLDGYVQRFIL------NGDFER 294

  Fly   602 MLFDPEIYFGG--GPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEFV 664
            :..|.|::.||  |.   .:|.||..:||.|.::.|.:|.::|.....|.:.::.:.|.:....:
Human   295 LNLDTEMFIGGLVGA---ARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCL 356

  Fly   665 ENEVNVIPITYPFATSHIWWPINHAE--------EFNIKFDFRSSRPGAVLAYSDVTTSAGNGFW 721
            :      |:.:|.   :...|.|..:        ...:.|.||:.....:|.:|.:    |:|..
Human   357 D------PVPHPI---NFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRL----GDGLG 408

  Fly   722 EIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATS-------WHSVELDYKLGEIRFTVDYRHTLS 779
            .:.||..:      ..||.::..|...|:..|..       ||         |:.|.....|.:.
Human   409 HVELTLSE------GQVNVSIAQSGRKKLQFAAGYRLNDGFWH---------EVNFVAQENHAVI 458

  Fly   780 QM-----------YGLTFNIGDKLIIGSSLKSAA--------MGLVGCIRDIEINGHLIEPRHVV 825
            .:           |.|....|.....|...|.|:        ....||:..::::|.|:. ..:|
Human   459 SIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVN-LTLV 522

  Fly   826 KTERV--VGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCE 888
            :..|:  ..||..|.|...|.|. ||.|||.|:|:...|...|.|:.|||.|:.||...|:::||
Human   523 EGRRLGFYAEVLFDTCGITDRCS-PNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCE 586

  Fly   889 ELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHN-LPSQVDVRSARESDFSFN 952
            ...|.|.|..: :.||.||:|...|..|.||.:  ||...|:|.|: |.:.....|:.|..|...
Human   587 AYRLSGKTSGN-FTIDPDGSGPLKPFVVYCDIR--ENRAWTVVRHDRLWTTRVTGSSMERPFLGA 648

  Fly   953 IRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSS---AKNLTVDFL-GNVKRG- 1012
            |:|...|...:..|.:.|.:|.|:|::.||.::| |::|..:..|   .:|....|. |..:.| 
Human   649 IQYWNASWEEVSALANASQHCEQWIEFSCYNSRL-LNTAGGYPYSFWIGRNEEQHFYWGGSQPGI 712

  Fly  1013 -ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITLGP 1076
             .|.|.::::||||...||||..:.:|.:|:|.......|.:|.:..........|||  ..|.|
Human   713 QRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQ--FFLRP 775

  Fly  1077 LECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAFSFRTTGEKAILLFQ---PPIRPHYPSFM 1135
            |.|.........::|.|..: :..|..|..   |::|.|||:....:.|..   |..:...|...
Human   776 LRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVR 839

  Fly  1136 VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLLPEE 1200
            |.|.....:.|.|.:..|.....|.:.....|..|||.:..:.|....|..::....:|..:|.:
Human   840 VELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQ 904

  Fly  1201 EF--GPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSC 1263
            .:  ..::..:|:|.|.   ||    :...:||.|.:.:||..|::..  ..:.||   ...|:|
Human   905 TYIWMEYDQPLYVGSAE---LK----RRPFVGCLRAMRLNGVTLNLEG--RANASE---GTSPNC 957

  Fly  1264 VPS------PCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNIN-------------EKALTFIN 1309
            ...      ||.:|.:|.|.:|.:.|.|:.. |..|.:|..:|.             :.||....
Human   958 TGHCAHPRLPCFHGGRCVERYSYYTCDCDLT-AFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAA 1021

  Fly  1310 RE--SFLMR-------NYLSVGATP--VILMHG--------------INGERDVLKGILNQDLLI 1349
            ||  ..|.|       .|:....||  |...||              :.|.|..:..:..:::..
Human  1022 REFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSF 1086

  Fly  1350 NLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDE--IVNLTLLDDTLMASLKSIQVAI 1412
            :..|....|::||.:....:::.:.|..:..:...|..|..  :..||....|   ..:...:.|
Human  1087 SFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVT---DGQPHSINI 1148

  Fly  1413 VRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPAN 1477
            .|..:...:.|:...::..:.:||:|...:.|.:                     .::|......
Human  1149 TRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKA---------------------LYLGRVMETG 1192

  Fly  1478 LLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAP 1517
            ::.|.:......|:.||:.|::.            .|:||
Human  1193 VIDPEIQRYNTPGFSGCLSGVRF------------NNVAP 1220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389
EGF_CA 433..476 CDD:238011 15/52 (29%)
Laminin_G_2 514..640 CDD:280389 34/143 (24%)
Laminin_G_2 698..817 CDD:280389 26/144 (18%)
EGF_CA 842..878 CDD:238011 16/35 (46%)
Laminin_G_2 1112..1240 CDD:280389 29/132 (22%)
EGF_CA 1256..1297 CDD:238011 12/46 (26%)
Laminin_G_2 1351..1503 CDD:280389 23/153 (15%)
LamG 1612..1733 CDD:304605
CNTNAP1NP_003623.1 FA58C 36..167 CDD:238014 13/44 (30%)
LamG 175..330 CDD:238058 39/171 (23%)
LamG 362..513 CDD:238058 30/172 (17%)
EGF 544..575 CDD:306513 15/31 (48%)
FReD 584..>658 CDD:294064 26/76 (34%)
LamG 787..937 CDD:238058 34/157 (22%)
LamG 1083..1218 CDD:214598 23/170 (14%)
4.1m 1304..1322 CDD:128590
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1319..1384
SH3-binding. /evidence=ECO:0000255 1328..1369
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11662
eggNOG 1 0.900 - - E1_KOG3516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.780

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