DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and cntnap5l

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_001338473.5	Gene:	cntnap5l / 798019	ZFINID:	ZDB-GENE-140106-102	Length:	1310	Species:	Danio rerio

Alignment Length:	1145	Identity:	275/1145 - (24%)
Similarity:	465/1145 - (40%)	Gaps:	241/1145 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR--ISLMFRTNFDDSAL 523
            |:..:.:|..|:.:..|        ..|.|.:.||.    ::..:||.:  |||.||::..:..|
Zfish   167 GLRLEVYGCTYKSDVAD--------FDGRSALLYRF----NQKSTSTVKDVISLRFRSHQAEGVL 219

  Fly   524 FYASGESLKHQYIAASIKNQSVHVEMDFGD----------NVMSTVLTDDLTRGYWHNLTILHEQ 578
            .:  ||..:..::...::...:.:.::..|          :||...|.||   .:||::.|....
Zfish   220 VH--GEGQRGDFLTLELQRGRLILHLNLDDAKPQSGGRSSSVMLGSLLDD---HHWHSVQIERFN 279

  Fly   579 RTVSIILD---------QQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKY 634
            :.|:..:|         .|:..||:          |.|:.|||.| |..|.|...|.||.|.::.
Zfish   280 KHVNFTVDGHTQHFRSLGQEDTLEI----------DYELSFGGIP-LPGKPGTFLHENFHGCIEN 333

  Fly   635 VYYNDISILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFAT-SHIWWPINHA-EEFNIKFD 697
            :.||.::::...:|..|:::..|  ...|..:|.:.:.:|:..:| |.:..|.::: :..:::..
Zfish   334 LNYNGVNVIDMAKRRKPQIYTVG--NVTFSCSESSSVAVTFLSSTGSFLALPADYSMDSLSVRLQ 396

  Fly   698 FRSSRPGAVLAYSDVTTSAGNGFW--EIRLTSDKLSFDLVPDVNNNVTHSTTIKI---------N 751
            ||:                    |  |..|.|..||.|  ||..|.:...:..::         |
Zfish   397 FRT--------------------WNQEGLLFSVPLSHD--PDPINLLLRLSQARLLLLLSGGPQN 439

  Fly   752 RAT----------SWHSVELDYKLGEIRFTV-DYRHTLSQMYG-------LTFNIGDKLIIGSSL 798
            .|.          .|||:.::.|..::..|| :.:....::.|       .|..||...:..|:.
Zfish   440 SAQVFSGQNLNDGQWHSISVEVKGEKVSLTVNNQKPATMEITGRSQTPQRTTIYIGGCPLFQSNF 504

  Fly   799 --KSAAMGLVGCIRDIEINGHLIEPRHVVKTERV----VGEVALDNCNYIDPCKRPNTCEHGGKC 857
              ::...|..||.|.:.||.|   |.:.::.::.    ..:::.|.||..|.| .||.|||||:|
Zfish   505 NCENPGRGYQGCFRLLLINNH---PVNFLQIQQENMGNFSQISFDVCNIQDRC-LPNLCEHGGQC 565

  Fly   858 FVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQS 922
            ....|:..|:|..|||.|..||.:.|.::||.....| ::|.|:.||:||:|:...|.|.|..
Zfish   566 IQSWDQFDCNCSGTGYTGATCHNSIYERSCEAFRKTG-SQSSVFTIDLDGSGLLDHAQVNCTV-- 627

  Fly   923 LENATKTIVEHNLPSQVDVR-SARESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL 986
            .|:...|:|.|:....:|:| |...|.|.....| ..||:.|:.|::.|.:|.|.:.|.|.:::|
Zfish   628 AEDKVWTVVGHDHMRPIDIRGSTPRSPFVLIFNY-TISPYHLRSLVTSSEHCQQEVIYRCRKSRL 691

  Fly   987 -ELHSAT----WFTSSAKNLTV--DFLGNVKRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGY 1044
             :....|    |........|.  .||..|::  |.||::..|.|.|..||||..::.|.:|.|.
Zfish   692 FDTWDGTPLSWWLDRDGVKRTYWGGFLPGVQQ--CSCSLDGNCRDMNYFCNCDADQDTWANDTGV 754

  Fly  1045 --YQD--PQS---LGITNMYFLQQKDMDDEAQGRITLGPLECVETNTQKYVVTFTTSQSYIEVPG 1102
              |:|  |.|   :|.||.         ..:|..:.:|||.|..........:|....||:..|.
Zfish   755 LSYKDHLPLSEIAIGDTNR---------TNSQAELQIGPLRCYGNRFFWNSASFYQESSYLHFPT 810

  Fly  1103 WRKG---DIAFSFRTTGEKAILLFQPPIRPHYPSFM-VALTGDDQLTFTFTLSTGTTRELVINSH 1163
            .:..   ||:..|:|:....:.|....:|    .|: :.|:....:.|||.|..|.. .|.:.|.
Zfish   811 LQAELSIDISLFFKTSAFSGVFLENLGVR----DFVRLELSSPSTMNFTFDLGDGPV-TLTVRSP 870

  Fly  1164 RRLNGGEWHKIWIDYNQYHVRFMINT-DYQMLDLLPEEEFG-PFEGSMYIGGATFDLLKKLSVKA 1226
            ..||..:||.|..:.|.......::: ..::.:..||:.:. .....:::||..       |.:.
Zfish   871 VALNDRQWHYIRAERNVKEASLQVDSLPLELTEAPPEKPYRLQLSSQLFVGGTA-------SRQR 928

  Fly  1227 GLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSCV-PSPCRNGAQCKELWSSFKCVCNNPWA 1290
            |.:||.|.|.:||..||::..... ...:...|...|. .|.|.||.:|.|..||:.|.|... |
Zfish   929 GFVGCLRALTINGVTLDLFERAKT-TPGVNSGCPGHCTSDSVCHNGGRCVEERSSYACDCTQT-A 991

  Fly  1291 HIGEFCETNINEKALTFINRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQD--------- 1346
            ..|..|     .|||.    .||      ..|::.:..:      ::...||||::
Zfish   992 FDGPHC-----RKALA----ASF------ESGSSVLYTL------QEPFSGILNEEARRSPAGFH 1035

  Fly  1347 ----------LLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTL 1401
                      :.....|....||:|.|:....|::.:.::.|..:...|....|       ..|.
Zfish  1036 DAEVAKSQEKVSFGFLTRHVPALILMAHTLDQNYMAVMLTSNGSLQIRYLMNKE-------KRTE 1093

  Fly  1402 MASLKSIQVAIVRGEQETRMH---VN----EHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPP 1459
            |.|.||..:|      :.|.|   :|    |..|.||  ..:..:|:..|.|     .|||.|
Zfish  1094 MFSPKSGSLA------DGRFHWVKINRKGQELLVQID--NTITQQYSLSPGS-----ALSPVR-- 1143

  Fly  1460 APPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLK 1499
                   ...:|....:::....:....|.|:|||:..::
Zfish  1144 -------SVILGRIQGSDITDKELVQAGLRGFIGCLSSVQ 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	34/144 (24%)
		Laminin_G_2	698..817	CDD:280389	31/149 (21%)
		EGF_CA	842..878	CDD:238011	17/35 (49%)
		Laminin_G_2	1112..1240	CDD:280389	30/130 (23%)
		EGF_CA	1256..1297	CDD:238011	14/41 (34%)
		Laminin_G_2	1351..1503	CDD:280389	35/156 (22%)
		LamG	1612..1733	CDD:304605
cntnap5l	XP_001338473.5	FA58C	37..174	CDD:238014	1/6 (17%)
		FA58C	48..175	CDD:214572	1/7 (14%)
		Laminin_G_2	210..339	CDD:280389	34/144 (24%)
		Laminin_G_2	397..525	CDD:280389	31/149 (21%)
		EGF_CA	552..586	CDD:238011	17/34 (50%)
		LamG	799..940	CDD:238058	35/152 (23%)
		EGF_CA	964..997	CDD:238011	13/33 (39%)
		Laminin_G_2	1050..1178	CDD:280389	35/156 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.780