DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and cntnap2

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:XP_031759324.1 Gene:cntnap2 / 780189 XenbaseID:XB-GENE-956230 Length:1338 Species:Xenopus tropicalis


Alignment Length:1176 Identity:283/1176 - (24%)
Similarity:479/1176 - (40%) Gaps:217/1176 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFY 525
            |:..:.:|       |. |.|.:|...|.|.:|||..:.|.:.....  |||.|:::..:..:|:
 Frog   172 GLRTELYG-------CP-YWADVINFDGNSGLSYRFKNKKMKTLKDV--ISLKFKSSESEGVIFH 226

  Fly   526 ASGESLKHQYIAASIKNQSVHVEMDFGDN----------VMSTVLTDDLTRGYWHNLTILHEQRT 580
              ||..:..||...:|...:.::::.|.|          |.|..|.||   .:||.:.|....|.
 Frog   227 --GEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYGHTSVTSGSLLDD---HHWHTVIIERHGRN 286

  Fly   581 VSIILDQQQKVLELPATASG---NMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISI 642
            :::.||:..:..:    .:|   ::..|.|:.|||.| ...|...:|..||.|.::.:.||.|:|
 Frog   287 INLTLDRHMQHFK----TNGDFESLDLDFELTFGGMP-FSGKPSSSSRKNFKGCMESINYNGINI 346

  Fly   643 LYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAEE-FNIKFDFRSSRPGAV 706
            . :|.| ..||..:.:....|...|...:|:.:. |||::.......|: .::.|.||:..|..:
 Frog   347 T-DLAR-RKKVEPYNMANLSFTCVESRSVPVFFN-ATSYLEVRGRPNEDLLSVSFQFRTWNPSGL 408

  Fly   707 LAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-------SWHSVELDYK 764
            |.|:..:...||  .||.||..|:|      |:.|:|.|...:|:.::       .||.|.|..|
 Frog   409 LLYNTFSDELGN--VEIDLTEGKVS------VHINMTKSKKNRIDISSGSGLNDGQWHEVRLTAK 465

  Fly   765 LGEIRFTVD------------------YRHTLSQMYGLTFNIGDKLIIGSSLKSAAMGLVGCIRD 811
            ......|||                  .|:.....|.|: |..|..::..|.:       ||::.
 Frog   466 ENFAILTVDGDEASSVRTNSPLQFQTGSRYFFGGFYSLS-NYTDHSLLQHSFQ-------GCMQL 522

  Fly   812 IEINGHLIEPRHVVKTER--VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYI 874
            |.::..|:: .|.|:..:  ....:::|.|..||.|. ||.|||||:|....|.:||:|:.|||.
 Frog   523 IHVDDQLVD-LHAVEQGKHGSYANISIDMCAIIDRCV-PNNCEHGGRCTQTWDSMTCNCEGTGYT 585

  Fly   875 GKNCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQV 939
            |..||.:.|..:||....|| ..||.|.||.||:|...|..|.|:.  .|:...|.:.|:|..|.
 Frog   586 GATCHNSIYELSCEAYKHLG-KSSDWYWIDPDGSGPLGPLKVFCNM--TEDKVWTTLFHDLSLQT 647

  Fly   940 DVRSAR-ESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL----ELHSATWFTSSAK 999
            .:.:|. :.....|:.| ..|...:..:...:.||.|||.|.|..::|    :.:..||:.... 
 Frog   648 PIVAASLDKPVVLNLNY-SASMEQISAITGSAEYCEQYISYSCRMSRLLNTPDGNPYTWWVGKG- 710

  Fly  1000 NLTVDFLGNVKRG--ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGY--YQD--PQSLGITNMYF 1058
            |....:.|....|  .|.|.:.:.|.|....||||..:.:|..|.|:  |:|  |.|..:....|
 Frog   711 NEKHHYWGGSSPGIQKCACGIERNCSDSKFHCNCDADQRQWRKDAGFLSYKDHLPVSQVVVGDTF 775

  Fly  1059 LQQKDMDDEAQGRITLGPLECVETNTQKYVVTFTTSQSYIE---VPGWRKGDIAFSFRTTGEKAI 1120
                  ...::.::::.||.|..........:|||..||:.   ..|....||:|.|:|:....:
 Frog   776 ------RSSSEAKLSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGV 834

  Fly  1121 LLFQPPIRPHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRF 1185
            .|..   |.......:.|..:.:::|.|.:..|.. ||::.|...||..:||::..:.|......
 Frog   835 FLEN---RGKTDFIKLELKSNTEVSFAFDVGNGPV-ELIVRSPSPLNDDQWHRVRAERNVKEASL 895

  Fly  1186 MINTDYQMLDLLP-EEEFGPFEG--------SMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEI 1241
            .:       |.|| :....|.:|        .:::|.|        ..:.|.:||.|.|.:||..
 Frog   896 QV-------DQLPWQLHKAPTQGHTRLELYSQLFVGAA--------GDQRGFLGCIRSLRMNGMT 945

  Fly  1242 LDIYSYMSVHLSEIIKDCKPSC------VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNI 1300
            ||:     ...::|....||.|      ....|:||.:|.|.::.:.|.|:.. |:.|.:|..::
 Frog   946 LDL-----EERAKITPGVKPGCSGHCTSFGMYCQNGGKCVEKYNGYTCDCSRT-AYDGPYCNKDV 1004

  Fly  1301 NEKALTFINRESFLMRNYLSVGATPVILMHGI-----NGERDVLKGILNQDLLINLRTYDTNALV 1360
            .    .:....::|..|:.|.....|:.....     :...|:  |:..::||.:..|..:..::
 Frog  1005 G----GYFEEGTWLRYNFHSASTAAVVSTKETGNIPQSSASDI--GLAKEELLFSFSTTKSPCIL 1063

  Fly  1361 LYANDHYNNFVHLYISLNREIVFLYNYG--DEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHV 1423
            ||.:.:..:::.:.:..:..:...||.|  .:..|:.:.|...||:          |:       
 Frog  1064 LYISSYSQDYLAVLLKASGILQIRYNLGGTKDPYNIDISDHKNMAN----------GQ------- 1111

  Fly  1424 NEHSVSIDRG----TLLLDEYANKPWSNPEKEVLSPHRPPA----PPTEYFQFHVGGYDPANLLR 1480
             .||::|.|.    ...||.|....::.|.......:.|.|    ...|..||  ||.....:|:
 Frog  1112 -PHSINITRSGRNVIFQLDHYPPAVYNLPSASDTQFNGPKALFLGKVIETQQF--GGQSQHQILK 1173

  Fly  1481 ------PNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLP--NCQI--------- 1528
                  .::.:....|:.||            |:.:....|||.:..:..  |.|:         
 Frog  1174 ETGTKDQDIHSYNTPGFSGC------------LSRVQFNLIAPLKAALRSSNNSQVFIQGELVES 1226

  Fly  1529 KCDAEP 1534
            .|.|.|
 Frog  1227 NCGASP 1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389
EGF_CA 433..476 CDD:238011 2/14 (14%)
Laminin_G_2 514..640 CDD:280389 34/138 (25%)
Laminin_G_2 698..817 CDD:280389 35/143 (24%)
EGF_CA 842..878 CDD:238011 19/35 (54%)
Laminin_G_2 1112..1240 CDD:280389 29/136 (21%)
EGF_CA 1256..1297 CDD:238011 12/46 (26%)
Laminin_G_2 1351..1503 CDD:280389 30/167 (18%)
LamG 1612..1733 CDD:304605
cntnap2XP_031759324.1 FA58C 41..179 CDD:238014 1/6 (17%)
LamG 186..342 CDD:238058 42/167 (25%)
LamG 374..526 CDD:238058 41/168 (24%)
EGF 557..588 CDD:394967 17/31 (55%)
COLFI 603..>631 CDD:413320 13/30 (43%)
LamG 799..942 CDD:238058 37/161 (23%)
EGF_CA 966..1000 CDD:238011 9/34 (26%)
Laminin_G_2 1054..1200 CDD:396680 31/177 (18%)
4.1m 1289..1307 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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