DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and CNTNAP3B

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001188309.2	Gene:	CNTNAP3B / 728577	HGNCID:	32035	Length:	1288	Species:	Homo sapiens

Alignment Length:	1127	Identity:	269/1127 - (23%)
Similarity:	446/1127 - (39%)	Gaps:	171/1127 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR--ISLMFRTNFDDSAL 523
            |:..:.:|..|:.|        ::...|.|.:.|.:    |:......|  |||.|:....:..|
Human   169 GMRIEVYGCAYKSE--------VVYFDGQSALLYTL----DKKPLKPIRDVISLKFKAMQSNGIL 221

  Fly   524 FYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTVLTDDLTRG------YWHNLTILHEQRTVS 582
            .:..|:...|..:.. ||.:.|.........:.||:....||.|      :||::.|......|:
Human   222 LHREGQHGNHITLEL-IKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVN 285

  Fly   583 IILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQ 647
            ..:|:.....:....:| |:..:.||.|||.....:.:.. :..:|.|.|:.:|||.:.:....:
Human   286 FTVDKHTHHFQAKGDSS-NLDLNFEISFGGILSPGRSRAF-TRKSFHGCLENLYYNGVDVTELAK 348

  Fly   648 RGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAEE-FNIKFDFRSSRPGAVLAYSD 711
            :..|::...|  ...|...:...:|:|:..:.|::..|.|..|: .::.|.||:......|.:.:
Human   349 KHKPQILMMG--NVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411

  Fly   712 VTTSAGNGFWEIRLTSDKLSFDL--VPDVNNNVTHSTTIKINRATSWHSVELDYKLGEIRFTVDY 774
            :  ..|:|.:.:.|...||...|  ......|||....:...:   ||||....|...:...||.
Human   412 L--QRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAGLNDGQ---WHSVSFSAKWSHMNVVVDD 471

  Fly   775 RHTLSQMYGLTFNIGDKLII--------GSSLKSAAMGLVGCIRDIEINGHLIEPRHVVKTERVV 831
            ...:..:..:..:.||....        ||..||...|..||:|.|.|....::|  ::..:..:
Human   472 DTAVQPLVAVLIDSGDTYYFGGCLGNSSGSGCKSPLGGFQGCLRLITIGDKAVDP--ILVQQGAL 534

  Fly   832 G---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELALL 893
            |   ::.:|:|...|.| .|:.|||||:|....|..:|||..|||.|:.||.:.|.::||.....
Human   535 GSFRDLQIDSCGITDRC-LPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHR 598

  Fly   894 GFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARE----SDFSFNIR 954
            | ..|.:|.||.||:|...|..|.|:..:  ::..|:|.|..|..|.:|.|..    |..||  .
Human   599 G-NPSGLYYIDADGSGPLGPFLVYCNMTA--DSAWTVVRHGGPDAVTLRGAPSGHPLSAVSF--A 658

  Fly   955 YREFSPHMLQELISHSLYCTQYIKYDCYRAQL-ELHSAT---WFTSSAKNLTVDFLGNVKRG-AC 1014
            |.. ....|:..::.:..|.|.:...|..|:. :....|   |:..........:.|::... .|
Human   659 YAA-GAGQLRAAVNLAERCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHTSWGGSLPDAQKC 722

  Fly  1015 PCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITLGPLEC 1079
            .|.:...|:|....||||..:|:|.||.......:.|.:|.:..........||.  .|||||.|
Human   723 TCGLEGNCIDSQYYCNCDAGQNEWTSDTIVLSQKEHLPVTQIVMTDTGQPHSEAD--YTLGPLLC 785

  Fly  1080 VETNTQKYVVTFTTSQSYIEVP---GWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGD 1141
            ....:.....:|.|..||:..|   |....|:.|.|:||....:.:....|...   ..:.|...
Human   786 RGDKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDF---IRIELRAP 847

  Fly  1142 DQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQML--DLLPEE-EFG 1203
            .::||:|.:..|.. |:.:.|....|..:||         |||...|.....|  |.||:: :..
Human   848 TEVTFSFDVGNGPC-EVTVQSPTPFNDNQWH---------HVRAERNVKGASLQVDQLPQKMQPA 902

  Fly  1204 PFEG--------SMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCK 1260
            |.:|        .::|||..       :.:.|.:||.|.|.:||..||:....:|     ....:
Human   903 PADGHVRLQLNSQLFIGGTA-------TRQRGFLGCIRSLQLNGVALDLEERATV-----TPGVE 955

  Fly  1261 PSCV------PSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINE-----KALTFINRESF- 1313
            |.|.      ...||||.:|:|......|.|... |:.|.||...|:.     .::|:..:|.:
Human   956 PGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFS-AYDGPFCSNEISAYFATGSSMTYHFQEHYT 1019

  Fly  1314 LMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLN 1378
            |..|..|:    |..:|     |||.  :..:.:.::.||..|.:|:||.:..|..::.:.::.|
Human  1020 LSENSSSL----VSSLH-----RDVT--LTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANN 1073

  Fly  1379 REIVFLYNYGDEIVN--LTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHS---VSIDRGTLLLD 1438
            ..:...|.. |...|  ....|...||..:..||.|.|.|....:.||:.:   |.:..||
Human  1074 GSLQIRYKL-DRHQNPDAFTFDFKNMADGQLHQVKINREEAVVMVEVNQSAKKQVILSSGT---- 1133

  Fly  1439 EYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQ 1503
            |:      |..|.::                :|....|....|:....|..|:.||:..::.|.
Human  1134 EF------NAVKSLI----------------LGKVLEAAGADPDTRRAATSGFTGCLSAVRFGC- 1175

  Fly  1504 LIDLADINERNIAPTQEGVLPN 1525
                       .||.:..:.|:
Human  1176 -----------AAPLKAALRPS 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	4/14 (29%)
		Laminin_G_2	514..640	CDD:280389	30/131 (23%)
		Laminin_G_2	698..817	CDD:280389	31/128 (24%)
		EGF_CA	842..878	CDD:238011	17/35 (49%)
		Laminin_G_2	1112..1240	CDD:280389	33/138 (24%)
		EGF_CA	1256..1297	CDD:238011	13/46 (28%)
		Laminin_G_2	1351..1503	CDD:280389	35/156 (22%)
		LamG	1612..1733	CDD:304605
CNTNAP3B	NP_001188309.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..61
		FA58C	54..176	CDD:238014	1/6 (17%)
		Laminin_G_2	212..341	CDD:308045	30/131 (23%)
		LamG	371..519	CDD:238058	37/152 (24%)
		EGF	551..582	CDD:306513	16/31 (52%)
		FReD	590..>635	CDD:294064	15/47 (32%)
		LamG	794..938	CDD:238058	40/163 (25%)
		Laminin_G_2	1046..1174	CDD:308045	34/154 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1215..1236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11662
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820