DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and Cntnap2

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_001004357.2 Gene:Cntnap2 / 66797 MGIID:1914047 Length:1332 Species:Mus musculus


Alignment Length:1244 Identity:298/1244 - (23%)
Similarity:471/1244 - (37%) Gaps:279/1244 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFY 525
            |:..:.:|       | .|.|.:|...|...:.||..:.|.:.....  |:|.|:|:..:..|.:
Mouse   173 GLRAEVYG-------C
-AYWADVINFDGHGVLPYRFRNKKMKTLKDV--IALKFKTSESEGVLLH 227

  Fly   526 ASGESLKHQYIAASIKNQSVHVEMDFGDN----------VMSTVLTDDLTRGYWHNLTILHEQRT 580
              ||..:..||...:|...:.:.::.|.|          |.|..|.||   .:||::.|..:.|:
Mouse   228 --GEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDD---HHWHSVLIERQGRS 287

  Fly   581 VSIILDQQQKVLELPATASGNMLF---DPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISI 642
            :::.||:..:...    .:|...:   |.||.|||.| ...|...::..||.|.::.:.||.::|
Mouse   288 INLTLDRSMQHFR----TNGEFDYLDLDYEITFGGIP-FSGKPSSSNRKNFKGCMESINYNGVNI 347

  Fly   643 LYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPF---ATSHIWWP--INHAEEFNIKFDFRSSR 702
            ....:|...:....|.|....||      |.|.|.   |||::..|  :|. :.|::.|.||:..
Mouse   348 TDLARRKKLEPSNMGNLSFSCVE------PYTVPVFFNATSYLEVPGRLNQ-DLFSVSFQFRTWN 405

  Fly   703 PGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-----SWHSVELD 762
            |..:|.:|....:.||  .||.|...|:..    .:||..|.::.|.|:..:     .||.|.. 
Mouse   406 PSGLLLFSHFADNLGN--VEIDLVESKVGV----HINNTQTKTSQIDISSGSGLNDGQWHEVRF- 463

  Fly   763 YKLGEIRFTV-----DYRHTLSQMYGLTFNIGDKLIIG--------SSLKSAAMGLVGCIRDIEI 814
              |.:..|.|     |....:.....|....|:|...|        :|..:......||::.|::
Mouse   464 --LAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQV 526

  Fly   815 NGHLIEPRHVVKTERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGK 876
            :..|:....|  ..|..|   .|.:|.|..||.|. ||.|||||||....|...|.|..|||.|.
Mouse   527 DDQLVNLYEV--AHRKPGSFANVTIDMCAIIDRCV-PNHCEHGGKCSQTWDSFKCTCDETGYSGA 588

  Fly   877 NCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDV 941
            .||.:.|..:||....||.| |:.|.||.||:|...|..|.|:.  .|:...|||.|:|..|..|
Mouse   589 TCHNSIYEPSCEAYKHLGQT-SNYYWIDPDGSGPLGPLKVYCNM--TEDKVWTIVSHDLQMQTTV 650

  Fly   942 RSARESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWFTSSAKNL 1001
            .......:|........|...:..:.|.:.||.||:.|.|..::| |::.     ||:...| |.
Mouse   651 VGYNPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRL-LNTPDGSPYTWWVGKA-NE 713

  Fly  1002 TVDFLGNVKRG--ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGY--YQD--PQSLGITNMYFLQ 1060
            ...:.|..:.|  .|.|.:.:.|.||...||||....:|..|.|:  |:|  |.|..:..     
Mouse   714 KHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVG----- 773

  Fly  1061 QKDMDDEAQG---RITLGPLECVETNTQKYVVTFTTSQSYIE---VPGWRKGDIAFSFRTTGEKA 1119
                |.:.||   ::::|||.|..........:|....||:.   ..|....||:|.|:|...:.
Mouse   774 ----DTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRG 834

  Fly  1120 ILL-------FQPPIRPHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWID 1177
            :.|       |          ..:.|....:::|:|.:..|.. |:|:.|...||..:||::..:
Mouse   835 VFLENLGNTDF----------IKLELKSATEVSFSFDVGNGPV-EIVVRSPSPLNDDQWHRVTAE 888

  Fly  1178 YNQYHVRFMINTDYQMLDLLPEE-EFGPFEG--------SMYIGGATFDLLKKLSVKAGLIGCFR 1233
            .|.......:       |.||:: ...|.||        .:::|||        ..:.|.:||.|
Mouse   889 RNVKQASLQV-------DRLPQQIRKAPTEGHTRLELYSQLFVGGA--------GGQQGFLGCIR 938

  Fly  1234 GLVVNGEILDIYSYMSVHLSEIIKDCKPSCVP--SPCRNGAQCKELWSSFKCVCNNPWAHIGEFC 1296
            .|.:||..||:.....| .|.....|...|..  :.|.||.:|.|.:..:.|.|:|. |:.|.||
Mouse   939 SLRMNGVTLDLEERAKV-TSGFKSGCSGHCTSYGANCENGGKCIEKYHGYSCDCSNT-AYDGTFC 1001

  Fly  1297 ETNINEKALTFINRESFLMRNYLSVGATPVILM--------HGINGERDVLKGILNQDLLINLRT 1353
            ..::.    .|.....:|..|:    ..|.:..        :..:.::.:...:..:.:..:..|
Mouse  1002 NKDVG----AFFEEGMWLRYNF----QAPAVTARDTGSRAENSADQQQHLAPDLAQEQIHFSFST 1058

  Fly  1354 YDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGD--EIVNLTLLDDTLMASLKSIQVAIVRGE 1416
            .....::||.:....:|:.:.:.....:...||.|.  |..|:. :|...||:          |:
Mouse  1059 TKAPCILLYVSSLTTDFLAVLVKPTGNLQIRYNLGGTREPFNID-VDHRNMAN----------GQ 1112

  Fly  1417 QETRMHVNEHSVSIDRG----TLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPAN 1477
                    .|||:|.|.    .|.||.|          ..:..|.|.:..|.:       ..|.:
Mouse  1113 --------PHSVNITRHERTIILKLDHY----------PAVGYHLPSSSDTLF-------NSPKS 1152

  Fly  1478 LLRPNV-------------DAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQ---------- 1519
            |....|             :.|   |:.||            |:.:...:|||.:          
Mouse  1153 LFLGKVIETGKIDQEIHKYNTP---GFTGC------------LSRVQFNHIAPLKAALRQTNASA 1202

  Fly  1520 ----EGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQR 1580
                :|.|  .:..|.|.|..        .:...|..|..|...|     :...|||...     
Mouse  1203 HVHIQGEL--VESNCGASPLT--------LSPMSSATDPWHLDHL-----DSASADFPYN----- 1247

  Fly  1581 KFELPGTGR 1589
                ||.|:
Mouse  1248 ----PGQGQ 1252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389
EGF_CA 433..476 CDD:238011 2/14 (14%)
Laminin_G_2 514..640 CDD:280389 35/138 (25%)
Laminin_G_2 698..817 CDD:280389 31/136 (23%)
EGF_CA 842..878 CDD:238011 19/35 (54%)
Laminin_G_2 1112..1240 CDD:280389 31/143 (22%)
EGF_CA 1256..1297 CDD:238011 13/42 (31%)
Laminin_G_2 1351..1503 CDD:280389 32/170 (19%)
LamG 1612..1733 CDD:304605
Cntnap2NP_001004357.2 FA58C 34..181 CDD:214572 2/14 (14%)
FA58C 58..180 CDD:238014 1/6 (17%)
Laminin_G_2 216..345 CDD:280389 35/138 (25%)
LamG 375..527 CDD:238058 39/161 (24%)
EGF_CA 555..590 CDD:238011 19/35 (54%)
COLFI 609..>632 CDD:295304 10/24 (42%)
LamG 800..943 CDD:238058 37/168 (22%)
EGF 967..>992 CDD:278437 7/24 (29%)
LamG 1051..1187 CDD:214598 33/186 (18%)
4.1m 1283..1301 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12035
eggNOG 1 0.900 - - E1_KOG3516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6555
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.730

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