DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axo and HHIP

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_071920.1	Gene:	HHIP / 64399	HGNCID:	14866	Length:	700	Species:	Homo sapiens

Alignment Length:	461	Identity:	87/461 - (18%)
Similarity:	148/461 - (32%)	Gaps:	171/461 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 ISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTVLTDDLTRGYWHNLTI 574
            :||.|..|:..:...|.|..:.:.::....      |      |::: .|:...::|...|.:.:
Human   285 LSLAFHPNYKKNGKLYVSYTTNQERWAIGP------H------DHIL-RVVEYTVSRKNPHQVDL 336

  Fly   575 LHEQRTVSIILDQQQKVLELPAT-ASGNMLFDPE----IYFGGG----PELHKKKGLASHNNFVG 630
                ||..:.|:    |.||... ..|.:||.|:    |..|.|    .::.:..||   ::|.|
Human   337 ----RTARVFLE----VAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGL---SDFTG 390

  Fly   631 S-LKYVYYNDI-SILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWP-----INH 688
            | |:.....|: ::.|.:.|.||  |:          |..|..|..:......   |     ..|
Human   391 SVLRLDVDTDMCNVPYSIPRSNP--HF----------NSTNQPPEVFAHGLHD---PGRCAVDRH 440

  Fly   689 AEEFNIKFDFRSSRPGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRA 753
            ..:.||..              .:..|..||                    .|.:.:..::|.:.
Human   441 PTDININL--------------TILCSDSNG--------------------KNRSSARILQIIKG 471

  Fly   754 TSWHSVE--LDYK---LGEIRFTVDYRHTLSQ-MYGLTFNIGDK----LIIGSS-------LKSA 801
            ..:.|..  |::|   .|.:.....||...|: :|| ::..||:    |.:..|       .|..
Human   472 KDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYG-SYVFGDRNGNFLTLQQSPVTKQWQEKPL 535

  Fly   802 AMGLVGCIRDIEINGH-------------------------------LIEPRHVVKTERV----- 830
            .:|..|..|.. .:||                               :::|:..:..|..
Human   536 CLGTSGSCRGY-FSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQ 599

  Fly   831 VGEVALDNCN------YIDP----CKRPN-------------TCEHGGKCFVKDDRVTCDCKHTG 872
            ..:.....|:      |..|    |..|.             .|.|||.| |:.::  |.|| .|
Human   600 PAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVC-VRPNK--CLCK-KG 660

  Fly   873 YIGKNC 878
            |:|..|
Human   661 YLGPQC 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389	28/135 (21%)
		Laminin_G_2	698..817	CDD:280389	22/135 (16%)
		EGF_CA	842..878	CDD:238011	15/52 (29%)
		Laminin_G_2	1112..1240	CDD:280389
		EGF_CA	1256..1297	CDD:238011
		Laminin_G_2	1351..1503	CDD:280389
		LamG	1612..1733	CDD:304605
HHIP	NP_071920.1	Folate_rec	38..220	CDD:281076
		GSDH	226..>428	CDD:285269	39/178 (22%)
		Interaction with SHH zinc binding site	376..388		2/14 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900