DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axo and Aplp2

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_037038.1	Gene:	Aplp2 / 64312	RGDID:	2128	Length:	765	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	85/422 - (20%)
Similarity:	138/422 - (32%)	Gaps:	135/422 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 CAGPGDPGPCKQYIYKWRYEPTTNECTNFIWGGCEGNPQNRFGTEAECLFHCIGGPHTLPPFLQS 183
            |:.....|||:..:.:|.::.:..:|..||:|||.|| :|.|.:|..|:..|   ...:||
  Rat   312 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGN-RNNFESEDYCMAVC---KTMIPP---- 368

  Fly   184 TTREPSTTESSMLLGLPYTQSPAQSPDGMGGAEGGDGTTPVPIEQRG------PELTFAETGQGK 242
               .|..|....:    |.::   |.|....|........:.|..|.      .|...||. |.|
  Rat   369 ---TPLPTNDVDV----YFET---SADDNEHARFQKAKEQLEIRHRSRMDRVKKEWEEAEL-QAK 422

  Fly   243 TFIFAKNNTFIQMDGDII------------QTFQLRLCR-EISFQFRTRL--------------- 279
            ....|:..|.||....::            |..:..|.| |.....|.|:
  Rat   423 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPR 487

  Fly   280 PHGLLV----YHNVKNPDRIN----------LDPYA-----------LYVIVEKGQLKVVHVFGK 319
            ||.:|.    |...:|.||::          :||..           |:||.|:....:..::..
  Rat   488 PHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKV 552

  Fly   320 HSTSVTVGESLNR---------DEWHS------VMVRID------------VHGARLIARVDNSQ 357
            ...:..:.|.::.         |::.|      |.||:.            .|....::..:::|
  Rat   553 PYVAQEIQEEIDELLQEQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPFHPFPSLSENEDTQ 617

  Fly   358 EEVYLKGLNHEYNYGVSTNLPSVVLVGG----LSSEEKLHGVKYITESF---------------- 402
            .|:|     |....|.........|:|.    ::|:.|:.....|.|:.
  Rat   618 PELY-----HPMKKGSGMAEQDGGLIGAEEKVINSKNKMDENMVIDETLDVKEMIFNAERVGGLE 677

  Fly   403 -----VGCIRNVVLSSGKAASDLLPIAPLVAT 429
                 ||.:|.....|..|...||.||..:||
  Rat   678 EEPDSVGPLREDFSLSSSALIGLLVIAVAIAT 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057	17/51 (33%)
		Laminin_G_2	275..411	CDD:280389	36/227 (16%)
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389
		Laminin_G_2	698..817	CDD:280389
		EGF_CA	842..878	CDD:238011
		Laminin_G_2	1112..1240	CDD:280389
		EGF_CA	1256..1297	CDD:238011
		Laminin_G_2	1351..1503	CDD:280389
		LamG	1612..1733	CDD:304605
Aplp2	NP_037038.1	A4_EXTRA	42..204	CDD:128326
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	46..139
		APP_N	49..147	CDD:280358
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	147..205
		APP_Cu_bd	149..204	CDD:289676
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..301
		Kunitz_BPTI	311..363	CDD:278443	18/54 (33%)
		APP_E2	367..549	CDD:289677	38/196 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..616		1/18 (6%)
		APP_amyloid	711..761	CDD:287486
		Interaction with DAB2. /evidence=ECO:0000250	751..765
		NPXY motif	752..757
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810