Protein Alignment axo and Cntnap5a

DIOPT Version :10

• Sequence 1: NP_001246631.1
• Gene: axo / 43923
• FlyBaseID: FBgn0262870
• Length: 2179
• Species: Drosophila melanogaster
• Sequence 2: NP_001357942.1
• Gene: Cntnap5a / 636808
• MGIID: 3643623
• Length: 1305
• Species: Mus musculus
• Alignment Length: 1119
• Identity: 268/1119 - (23%)
• Similarity: 469/1119 - (41%)
• Gaps: 171/1119 - (15%)

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR-ISLMFRTNFDDSALF 524
            |:..:.:|..|..:..|        ..|.|.:.||   :..:..|:.:. |||.|::...|..||
Mouse   166 GMRVEAYGCSYRSDVAD--------FDGRSSLLYR---FNQKTMSTLKDVISLKFKSMQGDGVLF 219

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGDN---VMSTV-------LTDDLTRGYWHNLTILHEQR 579
            :  ||..:..:|...::...:.:.::..|:   :.|||       |.||   .:||::.:....:
Mouse   220 H--GEGQRGDHITLELQKGRLALYLNLDDSKARLSSTVPLVILGSLLDD---QHWHSVLLERVGK 279

  Fly   580 TVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILY 644
            ..:..:|...:....... :.::..|.|:.|||.| :..|.|.....||.|.::.:|||.::|:.
Mouse   280 QANFTVDMNTQHFRTKGD-TDSLDIDYELSFGGIP-VPSKPGTFLKKNFHGCIENLYYNGVNIID 342

  Fly   645 ELQRGNPKVHYHGVLEAEFVENEVNVIPITY-PFATSHIWWP-INHAEEFNIKFDFRSSRPGAVL 707
            ..:|...:::..|  ...|..:|..::|||: ...:|::..| ....:..::.|.||:.....:|
Mouse   343 LAKRRKHQIYSVG--NVTFSCSEPQIVPITFINSRSSYLMLPGTPQIDGLSVSFQFRTWNEDGLL 405

  Fly   708 AYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATS---WHSVELDYKLGEIR 769
            ..:::  |.|:|...:.|....|.. |:..|   ..|.|.|......:   ||||.::.:...:.
Mouse   406 LSTEL--SEGSGTLLLILEGGTLRL-LIKKV---ARHGTEILTGSGLNDGLWHSVSINARRNRVT 464

  Fly   770 FTVDYRHTLS--------QMY-GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPR 822
            .|:| ....|        |:| |.::..|   |.| ..|...:......||:|.|.|:.   :|:
Mouse   465 LTLD-NDAASPAPDTSRIQIYSGKSYYFGGCPDNL-TDSQCLNPIKAFQGCMRLIFIDN---QPK 524

  Fly   823 HVVKTER----VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKY 883
            .::..::    ...::.:|.|:..|.| .||.|||||.|........|:|..|||.|..||.:.|
Mouse   525 DLISVQQGSLGSFSDLHIDLCSIKDRC-LPNYCEHGGHCDQTWTTFYCNCSGTGYTGATCHDSIY 588

  Fly   884 RKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-SARES 947
            .::||.....|.|....| :|.||:|...|..|.|:.  .|:.....|:||......|: |:.|:
Mouse   589 EQSCEVYRHRGHTAGFFY-VDSDGSGPLGPLQVYCNI--TEDKIWMTVQHNNTELTRVQGSSPEN 650

  Fly   948 DFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWF--TSSAKNLTVDF 1005
            .:|..:.|.. |...|:.||..|.||.|.:.|.|.|::| |::.     ||:  .|:.::   .:
Mouse   651 PYSMTLNYGG-SMEQLEALIDGSEYCEQEVIYHCRRSRL-LNTPDGAPFTWWIGRSTERH---PY 710

  Fly  1006 LGNVKRGA--CPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEA 1068
            .|....|.  |.|.:.::|:|....||||...::|.:|.|.:.....|.:|.:..:.....:.||
Mouse   711 WGGAVPGVQQCGCGLEESCLDSRHFCNCDADIDEWANDTGLFSFKDHLPVTQIIIMDTNRTNSEA 775

  Fly  1069 QGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPPIRPH 1130
            ..||  |||.|.........|:|:|..||:..|.:.   ..||:|.|:||....:.|....|:..
Mouse   776 AWRI--GPLRCYGDRHFWNAVSFSTEASYLHFPTFHTEFSADISFFFKTTALSGVFLENLGIKDF 838

  Fly  1131 YPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLD 1195
               |.:.::...::||...:..|.. ||::.|...||..:||.|..:.|      :..|..| :|
Mouse   839 ---FRLEMSSPSEVTFAIDVGNGPI-ELLVQSPYPLNDNQWHYIRAETN------LKETSLQ-VD 892

  Fly  1196 LLPE-----EEFGPF----EGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVH 1251
            .||:     .|.|.|    ...:::||.:       |.:.|.:||.|.|::||..:|:.....|
Mouse   893 NLPQSMREASEGGHFRLQLNSQLFVGGTS-------SRQKGFLGCIRSLLLNGHKVDLEERAKV- 949

  Fly  1252 LSEIIKDCKPSC--VPSPCRNGAQCKELWSSFKCVC-NNPWAHIGEFCETNINE-----KALTFI 1308
            .|.:...|...|  ..|.|.||.:|.|..:.:.|.| |:|:.  |.||...|:.     .::|::
Mouse   950 TSGVRPGCPGHCSSYGSNCHNGGKCVEKHTGYSCDCTNSPYE--GPFCRKEISALFDSGTSVTYM 1012

  Fly  1309 NRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHL 1373
            .:|.:.:....|:.::.:.        .|:..  ..:.::::..|.....|:||.|....||:.:
Mouse  1013 FQEPYPVTKNTSLSSSAIY--------TDLAP--FKETIMLSFMTTQAPTLLLYLNFSSQNFLAI 1067

  Fly  1374 YISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLD 1438
            .:|.|..:...|....:..::..:|...:|:.:..||.|.|...|..:.:::...|..
Mouse  1068 LLSRNGSLQVRYRLSKDESHVFNMDTENLANRRVHQVKISRDGPELSIQMDQQLFSYS------- 1125

  Fly  1439 EYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQ 1503
                   .:||.|..:..          ...:|.......|.|.|......|::||
Mouse  1126 -------FSPEVEFRTLR----------SLVLGKVTETLDLDPEVARANTLGFVGC--------- 1164

  Fly  1504 LIDLADINERNIAP 1517
               |:.:...:|||
Mouse  1165 ---LSSVQYNHIAP 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	Kunitz-type	119..170	CDD:438633
		Laminin_G_2	275..413	CDD:460494
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:460494	31/135 (23%)
		Laminin_G_2	698..817	CDD:460494	32/133 (24%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:460494	35/136 (26%)
		EGF_CA	1256..1297	CDD:238011	14/43 (33%)
		Laminin_G_2	1351..1503	CDD:460494	28/151 (19%)
		Laminin_G_2	1612..1733	CDD:460494
		PHA03247	<1895..2164	CDD:223021
Cntnap5a	NP_001357942.1	FA58C	56..173	CDD:238014	1/6 (17%)
		Laminin_G_2	209..338	CDD:460494	31/135 (23%)
		Laminin_G_2	396..522	CDD:460494	32/136 (24%)
		EGF	551..582	CDD:394967	15/31 (48%)
		LamG	793..937	CDD:238058	43/161 (27%)
		EGF_CA	961..995	CDD:238011	12/35 (34%)
		Laminin_G_2	1045..1173	CDD:460494	29/163 (18%)