DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and Cntnap5a

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_001357942.1 Gene:Cntnap5a / 636808 MGIID:3643623 Length:1305 Species:Mus musculus


Alignment Length:1119 Identity:268/1119 - (23%)
Similarity:469/1119 - (41%) Gaps:171/1119 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR-ISLMFRTNFDDSALF 524
            |:..:.:|..|..:..|        ..|.|.:.||   :..:..|:.:. |||.|::...|..||
Mouse   166 GMRVEAYG
CSYRSDVAD--------FDGRSSLLYR---FNQKTMSTLKDVISLKFKSMQGDGVLF 219

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGDN---VMSTV-------LTDDLTRGYWHNLTILHEQR 579
            :  ||..:..:|...::...:.:.::..|:   :.|||       |.||   .:||::.:....:
Mouse   220 H--GEGQRGDHITLELQKGRLALYLNLDDSKARLSSTVPLVILGSLLDD---QHWHSVLLERVGK 279

  Fly   580 TVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILY 644
            ..:..:|...:....... :.::..|.|:.|||.| :..|.|.....||.|.::.:|||.::|:.
Mouse   280 QANFTVDMNTQHFRTKGD-TDSLDIDYELSFGGIP-VPSKPGTFLKKNFHGCIENLYYNGVNIID 342

  Fly   645 ELQRGNPKVHYHGVLEAEFVENEVNVIPITY-PFATSHIWWP-INHAEEFNIKFDFRSSRPGAVL 707
            ..:|...:::..|  ...|..:|..::|||: ...:|::..| ....:..::.|.||:.....:|
Mouse   343 LAKRRKHQIYSVG--NVTFSCSEPQIVPITFINSRSSYLMLPGTPQIDGLSVSFQFRTWNEDGLL 405

  Fly   708 AYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATS---WHSVELDYKLGEIR 769
            ..:::  |.|:|...:.|....|.. |:..|   ..|.|.|......:   ||||.::.:...:.
Mouse   406 LSTEL--SEGSGTLLLILEGGTLRL-LIKKV---ARHGTEILTGSGLNDGLWHSVSINARRNRVT 464

  Fly   770 FTVDYRHTLS--------QMY-GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPR 822
            .|:| ....|        |:| |.::..|   |.| ..|...:......||:|.|.|:.   :|:
Mouse   465 LTLD-NDAASPAPDTSRIQIYSGKSYYFGGCPDNL-TDSQCLNPIKAFQGCMRLIFIDN---QPK 524

  Fly   823 HVVKTER----VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKY 883
            .::..::    ...::.:|.|:..|.| .||.|||||.|........|:|..|||.|..||.:.|
Mouse   525 DLISVQQGSLGSFSDLHIDLCSIKDRC-LPNYCEHGGHCDQTWTTFYCNCSGTGYTGATCHDSIY 588

  Fly   884 RKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-SARES 947
            .::||.....|.|....| :|.||:|...|..|.|:.  .|:.....|:||......|: |:.|:
Mouse   589 EQSCEVYRHRGHTAGFFY-VDSDGSGPLGPLQVYCNI--TEDKIWMTVQHNNTELTRVQGSSPEN 650

  Fly   948 DFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWF--TSSAKNLTVDF 1005
            .:|..:.|.. |...|:.||..|.||.|.:.|.|.|::| |::.     ||:  .|:.::   .:
Mouse   651 PYSMTLNYGG-SMEQLEALIDGSEYCEQEVIYHCRRSRL-LNTPDGAPFTWWIGRSTERH---PY 710

  Fly  1006 LGNVKRGA--CPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEA 1068
            .|....|.  |.|.:.::|:|....||||...::|.:|.|.:.....|.:|.:..:.....:.||
Mouse   711 WGGAVPGVQQCGCGLEESCLDSRHFCNCDADIDEWANDTGLFSFKDHLPVTQIIIMDTNRTNSEA 775

  Fly  1069 QGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPPIRPH 1130
            ..||  |||.|.........|:|:|..||:..|.:.   ..||:|.|:||....:.|....|:..
Mouse   776 AWRI--GPLRCYGDRHFWNAVSFSTEASYLHFPTFHTEFSADISFFFKTTALSGVFLENLGIKDF 838

  Fly  1131 YPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLD 1195
               |.:.::...::||...:..|.. ||::.|...||..:||.|..:.|      :..|..| :|
Mouse   839 ---FRLEMSSPSEVTFAIDVGNGPI-ELLVQSPYPLNDNQWHYIRAETN------LKETSLQ-VD 892

  Fly  1196 LLPE-----EEFGPF----EGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVH 1251
            .||:     .|.|.|    ...:::||.:       |.:.|.:||.|.|::||..:|:.....| 
Mouse   893 NLPQSMREASEGGHFRLQLNSQLFVGGTS-------SRQKGFLGCIRSLLLNGHKVDLEERAKV- 949

  Fly  1252 LSEIIKDCKPSC--VPSPCRNGAQCKELWSSFKCVC-NNPWAHIGEFCETNINE-----KALTFI 1308
            .|.:...|...|  ..|.|.||.:|.|..:.:.|.| |:|:.  |.||...|:.     .::|::
Mouse   950 TSGVRPGCPGHCSSYGSNCHNGGKCVEKHTGYSCDCTNSPYE--GPFCRKEISALFDSGTSVTYM 1012

  Fly  1309 NRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHL 1373
            .:|.:.:....|:.::.:.        .|:..  ..:.::::..|.....|:||.|....||:.:
Mouse  1013 FQEPYPVTKNTSLSSSAIY--------TDLAP--FKETIMLSFMTTQAPTLLLYLNFSSQNFLAI 1067

  Fly  1374 YISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLD 1438
            .:|.|..:...|....:..::..:|...:|:.:..||.|.|...|..:.:::...|..       
Mouse  1068 LLSRNGSLQVRYRLSKDESHVFNMDTENLANRRVHQVKISRDGPELSIQMDQQLFSYS------- 1125

  Fly  1439 EYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQ 1503
                   .:||.|..:..          ...:|.......|.|.|......|::||         
Mouse  1126 -------FSPEVEFRTLR----------SLVLGKVTETLDLDPEVARANTLGFVGC--------- 1164

  Fly  1504 LIDLADINERNIAP 1517
               |:.:...:|||
Mouse  1165 ---LSSVQYNHIAP 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389
EGF_CA 433..476 CDD:238011 3/14 (21%)
Laminin_G_2 514..640 CDD:280389 31/135 (23%)
Laminin_G_2 698..817 CDD:280389 32/133 (24%)
EGF_CA 842..878 CDD:238011 16/35 (46%)
Laminin_G_2 1112..1240 CDD:280389 35/136 (26%)
EGF_CA 1256..1297 CDD:238011 14/43 (33%)
Laminin_G_2 1351..1503 CDD:280389 28/151 (19%)
LamG 1612..1733 CDD:304605
Cntnap5aNP_001357942.1 FA58C 56..173 CDD:238014 1/6 (17%)
LamG 205..338 CDD:214598 34/139 (24%)
Laminin_G_2 396..519 CDD:366983 31/130 (24%)
EGF 551..582 CDD:333761 15/31 (48%)
LamG 793..937 CDD:238058 43/161 (27%)
EGF_CA 961..995 CDD:238011 12/35 (34%)
Laminin_G_2 1045..1170 CDD:366983 29/160 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12035
eggNOG 1 0.900 - - E1_KOG3516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.770

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