DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Nrxn1

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_038968743.1	Gene:	Nrxn1 / 60391	RGDID:	628659	Length:	1516	Species:	Rattus norvegicus

Alignment Length:	1454	Identity:	317/1454 - (21%)
Similarity:	509/1454 - (35%)	Gaps:	450/1454 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 FAETGQGKTFIFAKNNTFIQMDGDIIQTFQLRLC--REISFQFRTRLPHGLLVYHNVKNPDRINL 297
            :||.|.|..|..|        :|...:..:...|  .|:|||.:||...||::|.     |....
  Rat    24 WAELGSGLEFPGA--------EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYF-----DDEGF 75

  Fly   298 DPYALYVIVEKGQLKV-VHVFGKHSTSVTVGESLNRDEWHSVMVRIDVHGARL-IARVDNSQEEV 360
            ..:...::...|:|:: ..:|.....::.....:|...||||.:|.......| |.|.:....||
  Rat    76 CDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEV 140

  Fly   361 YLKGLNHEYNYGVSTNLPSVVLVGGLSSEEKLHGVKYI------TESFVGCIRNVVLSSGKAASD 419
            ..|..:        ..:.|.:.||||..|.:...:|..      .|.|.|.||:|.::|.:|
  Rat   141 KSKRRD--------MTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQA--- 194

  Fly   420 LLPI-APLVATKHENVNEGCSDMCESRHNLCFVGSRCINHYGGIS--------CDCFGTHYEGEH 475
             ||: ...|....|..|.|....||:...  ..|..|:|  ||:.        |||..|.:.|:.
  Rat   195 -LPVDGSEVKLDEEPPNSGGGSPCEAGDE--GDGGVCLN--GGVCSVVDDQAVCDCSRTGFRGKD 254

  Fly   476 C------------------------DIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRT 516
            |                        :.|   |.|.:|:.|..|.:.  ::.:.||:..|:|.|:|
  Rat   255 CSQEDNNVEGLAHLMMGDQGKSKGKEEY---IATFKGSEYFCYDLS--QNPIQSSSDEITLSFKT 314

  Fly   517 NFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV---LTDDLTRGYWHNLTIL--- 575
             ...:.|...:|:|.  .|:..::||.:|.:.::.|......:   :........||::.:.
  Rat   315 -LQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNL 376

  Fly   576 -------HEQRTVSI--ILDQQQKVLELPATASG------NML-FDPEIYFGGGPELHKKKGLAS 624
                   |...|:|:  ||           |.:|      .|| .|...|.||.|......|...
  Rat   377 RQHSGIGHAMVTISVDGIL-----------TTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPV 430

  Fly   625 HNNFVGSLKYVYYNDISILYELQR----GNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWP 685
            .|||:|.||.|.|.:..:..||.|    |:||:..|||: |...||...:.|||:....|.|..|
  Rat   431 SNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV-AFKCENVATLDPITFETPESFISLP 494

  Fly   686 INHAEEF-NIKFDFRSSRPGAVLAYSDVTTSAGNG-----------------FWEIRLTSDKLSF 732
            ..:|::. :|.||||::.|..::.:|       :|                 |:.|.:....|.
  Rat   495 KWNAKKTGSISFDFRTTEPNGLILFS-------HGKPRHQKDAKHPQMIKVDFFAIEMLDGHLY- 551

  Fly   733 DLVPDVNNNVTHSTTIKINRAT------SWHSVEL--DYKLGEIRFTVDYRHTLSQMY-----GL 784
             |:.|:.     |.||||....      .|:.|:.  |.:.|.|..     :||...|     ..
  Rat   552 -LLLDMG-----SGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISV-----NTLRTPYTAPGESE 605

  Fly   785 TFNIGDKLIIGSSLKSAA--------------MGLVGCIRDIEINGHLIEPRHVVKTERVVGEVA 835
            ..::.|:|.:|...::.|              .|.||||||:.|:|...:.|.:.:.:...|...
  Rat   606 ILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKP 670

  Fly   836 LDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELALLGFTKSDV 900
            ..:.....|| ..|.|::.|.|....:|..|||..|||:|::|.        .|..:|.:..|..
  Rat   671 SCSRETAKPC-LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE--------REATVLSYDGSMF 726

  Fly   901 YLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYREFSPHMLQE 965
            ..|.:                       .:|.|.....|.:|
  Rat   727 MKIQL-----------------------PVVMHTEAEDVSLR----------------------- 745

  Fly   966 LISHSLYCTQYIKYDCYRAQ--LELHSATWFTSSAKNLTVDF-LGNVKRGACPCSVNKTCVDPNQ 1027
                            :|:|  ..:..||....||..|.::. .|.||     .:||..|:..|
  Rat   746 ----------------FRSQRAYGILMATTSRDSADTLRLELDAGRVK-----LTVNLDCIRIN- 788

  Fly  1028 SCNC-----------DVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDE-------------- 1067
             ||.           ::.:|:|::.. ..:..:||.:|         :||:
  Rat   789 -CNSSKGPETLFAGYNLNDNEWHTVR-VVRRGKSLKLT---------VDDQQAMTGQMAGDHTRL 842

  Fly  1068 -----AQGRIT------------LGPLECVETNTQKYV--------------------------V 1089
                 ..|.||            :|.|:.:..|...|:                          |
  Rat   843 EFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPV 907

  Fly  1090 TFTTSQSYI---EVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPS-----FMVALTGDDQLTF 1146
            ||.|..||:   .:..:....:.|.|:||....::|        |.|     |:|.......|.:
  Rat   908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLIL--------YNSGDGNDFIVVELVKGYLHY 964

  Fly  1147 TFTLSTGTTRELVINSHRRLNGGEWHKIWI--DYNQYH-------VRFMINTDYQMLDLLPEEEF 1202
            .|.|..|... :..:|::.||..:||.:.|  |.:..|       :...|....:.|||
  Rat   965 VFDLGNGANL-IKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDL------ 1022

  Fly  1203 GPFEGSMYIGGA---TFDLLKKL-SVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCK--- 1260
               :..:||||.   |:..|.|| ..|.|..||...:.:||.:.|:.|.......:|.:.|:
  Rat  1023 ---KSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEVAL 1084

  Fly  1261 -------PS--CVPSPCRNGAQCKELWSSFKC----------VCNNP----------------WA 1290
                   ||  |....|.|...|.:.|..|.|          :||:|                |.
  Rat  1085 MKADLQGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1149

  Fly  1291 HIGEFCETNINEKALTF--INRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRT 1353
            . .:...|..:..|:.|  :.:|:.|:|...|.|....:.:|...|:..|...:...|:.|.
  Rat  1150 P-NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE--- 1210

  Fly  1354 YDTNALVLYANDHYNNF----------------VHLYISLNREIVFL--------YNYGDEIVNL 1394
             ::||::.....|...|                :..|.:.|.:...|        |..| .:|:.
  Rat  1211 -ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLG-RVVDE 1273

  Fly  1395 TLLDDTLMASLKSIQVAIVRGEQE 1418
            .|||.....::.:.|..|:.|.:|
  Rat  1274 WLLDKGRQLTIFNSQATIIIGGKE 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389	34/143 (24%)
		EGF_CA	433..476	CDD:238011	14/50 (28%)
		Laminin_G_2	514..640	CDD:280389	35/147 (24%)
		Laminin_G_2	698..817	CDD:280389	35/162 (22%)
		EGF_CA	842..878	CDD:238011	14/35 (40%)
		Laminin_G_2	1112..1240	CDD:280389	37/145 (26%)
		EGF_CA	1256..1297	CDD:238011	14/78 (18%)
		Laminin_G_2	1351..1503	CDD:280389	17/92 (18%)
		LamG	1612..1733	CDD:304605
Nrxn1	XP_038968743.1	LamG	30..190	CDD:238058	43/180 (24%)
		LamG	307..446	CDD:214598	37/152 (24%)
		LamG	503..652	CDD:214598	38/167 (23%)
		EGF_CA	680..713	CDD:238011	13/33 (39%)
		LamG	741..877	CDD:214598	31/191 (16%)
		Laminin_G_2	933..1061	CDD:396680	37/145 (26%)
		LamG	1134..>1253	CDD:238058	20/123 (16%)
		Syndecan	1441..>1476	CDD:395821
		4.1m	1461..1479	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910