DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and cntnap5b

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_009294485.1	Gene:	cntnap5b / 571891	ZFINID:	ZDB-GENE-070705-209	Length:	1306	Species:	Danio rerio

Alignment Length:	1192	Identity:	280/1192 - (23%)
Similarity:	471/1192 - (39%)	Gaps:	217/1192 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR--ISLMFRTNFDDSAL 523
            |:..:.:|..|:.:..|        ..|.|.:.||.    ::..:||.:  |||.|::...|..|
Zfish   170 GLRVEVYGCAYKSDVAD--------FNGRSSLLYRF----NQKSTSTVKDVISLRFKSQRADGVL 222

  Fly   524 FYASGESLKHQYIAASIK--NQSVHVEMDFGD--------NVMSTVLTDDLTRGYWHNLTILHEQ 578
            .:  ||..:..||...:.  ..::|:.:|...        :|....|.||   .:||::.|....
Zfish   223 VH--GEGQRGDYITLELHKGRLALHINLDDAKTHPSSGHVSVFLGGLLDD---QHWHSVLIERFN 282

  Fly   579 RTVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISIL 643
            :.::..:|:..|.:. ......::..|.|:.|||.| |..|.|.....||.|.::.:|||.::|:
Zfish   283 KQINFTVDRLTKHVR-TGGLDDSLEVDYELSFGGIP-LPGKPGTFLRKNFHGCMENLYYNGVNII 345

  Fly   644 YELQRGNPKVHYHGVLEAEFVENEVNVIPITY-PFATSHIWWPINH-AEEFNIKFDFRS-SRPGA 705
            ...:|..|:::..|  ...|..:|..:|..|: ..::|.:..|::. ||..::...||: :|.|.
Zfish   346 DLAKRRKPQIYSVG--NVSFSCSEPVLISSTFLSSSSSFLALPLDSAAETLSVSLQFRTWNREGM 408

  Fly   706 VLAYSDVTTSAGNGFWEIRLTSDKLSFDLVP-----DVNNNVTHSTTIKINRATS---WHSVELD 762
            :|       |.|.|     ..|:||...||.     ..:.:...|:.|.|.:|.|   ||::.:.
Zfish   409 LL-------SVGLG-----KDSEKLLLLLVHGQLRLSHHRSALQSSDIVIGQALSDGQWHTLSIS 461

  Fly   763 YKLGEIRFTVDYRHTLSQMYGLTFNIGDKLIIG--------SSLKSAAMGLVGCIRDIEING--- 816
            ....::...||.....:.........|..|:||        ...::..|...||:|.:.||.
Zfish   462 IAGYQVSLAVDDEPPSTMQMKEVALPGKSLLIGGCPSVLSNQGCRNPTMAYQGCMRSVVINNKPI 526

  Fly   817 --HLIEPRHVVKTERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGK 876
              :|::       :.::|   ::..|.|...|.| .||.|||.|.|........|||..|||.|.
Zfish   527 NFYLVQ-------QGLLGNYSKLQFDICGIRDRC-LPNYCEHDGVCSQSWSTFFCDCSGTGYTGA 583

  Fly   877 NCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDV 941
            .||.:.:..:||...|.| :.|..:.||.||:|......|.|:.  .::...|:|.||..:.|.|
Zfish   584 TCHNSIFEPSCEAHRLTG-SASGFFSIDPDGSGPLKSTVVYCNI--TDDKVWTVVNHNSTAMVRV 645

  Fly   942 R-SARESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL-ELHSAT----WFTSSAKN 1000
            : |:.:........| ..|...|:.|:..|.:|.|.:.|.|.:::| .....|    |...:.:.
Zfish   646 QGSSLQQPHVMTFNY-STSLEQLRTLVGRSEHCQQEVVYLCRKSRLFNTWDGTPLSWWLDRAGER 709

  Fly  1001 LTV--DFLGNVKRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKD 1063
            .|.  .||..|::  |.||:::.|:|.|..||||...:.|.:|.|.....:.|.:|.:.......
Zfish   710 RTYWGGFLPGVQQ--CACSLDENCIDMNHFCNCDADRSSWENDTGILSYKEHLPVTEILVGDTNR 772

  Fly  1064 MDDEAQGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQP 1125
            ...||..||  |.|.|..........:|....||:..|..:   ..||:..|:||....:.|...
Zfish   773 SGSEAIYRI--GSLHCFGDRFLWNAASFYQESSYLHFPTLQAELSVDISLYFKTTAPSGVFLENL 835

  Fly  1126 PIRPHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTD 1190
            ..:..   ..:.|:|...:||||.:..|.. .|.:.||..||..:||.:..:.|.......:
Zfish   836 GTKDF---IRLELSGPSVVTFTFDVGNGPV-VLTVKSHVPLNDKQWHYVRSERNVREASLQV--- 893

  Fly  1191 YQMLDLLPEEEF-GPFEG--------SMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYS 1246
                |.||.... .|.||        .::|||..       |.:.|.:||.|.|.:||..||:..
Zfish   894 ----DQLPLRFLEAPSEGHTHLQLNSQLFIGGTA-------SRQRGFLGCIRSLNINGMTLDLEE 947

  Fly  1247 YMSVHLSEIIKDCKPSCVP--SPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNI-----NEKA 1304
            ...: ...:...|...|..  |.|.|..:|.|..|.:.|.|.:. |:.|..|:..:     :..:
Zfish   948 RAKM-TPGVSSGCPGHCSSQNSLCHNRGKCIEKSSGYVCDCTHS-AYGGPNCKKEVSVSFESGSS 1010

  Fly  1305 LTFINRESF-LMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYN 1368
            :|:..:|.| :|||:..  .:..|.....|....:....|         |..|.|::|..|.::.
Zfish  1011 VTYTFQEPFSVMRNHSR--QSSAIFAQSSNSRESIAFSFL---------TTQTPAMLLTVNTYHQ 1064

  Fly  1369 NFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHS----VS 1429
            .::.:.::.|..:...|.     :|.....|..|.:  |:.:|  .||.. |:.::...    |.
Zfish  1065 QYMAIILAHNGSLQIWYR-----LNREKDPDIFMPT--SLNLA--NGELH-RVQIHREGRDMYVQ 1119

  Fly  1430 IDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALE----G 1490
            ||:.|.|  :|:    .:.:||:::..          ...:|....    |..||...|:    |
Zfish  1120 IDKDTNL--KYS----LSTDKELITIR----------SLTLGKVTG----RAGVDEEVLQAGSRG 1164

  Fly  1491 YIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCE 1555
            :|||            |:.:...::||.:..:|             |.|:...:....|...:|
Zfish  1165 FIGC------------LSSVQFNHLAPLKAAIL-------------NRGSSLVNVLGNLVESNC- 1203

  Fly  1556 HTSFLGEFCSEEKGADFSGEST 1577
                 ||...:......| :||
Zfish  1204 -----GELADKSSSRSLS-DST 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	33/135 (24%)
		Laminin_G_2	698..817	CDD:280389	32/140 (23%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:280389	35/136 (26%)
		EGF_CA	1256..1297	CDD:238011	12/42 (29%)
		Laminin_G_2	1351..1503	CDD:280389	32/159 (20%)
		LamG	1612..1733	CDD:304605
cntnap5b	XP_009294485.1	FA58C	57..178	CDD:214572	1/7 (14%)
		FA58C	57..177	CDD:238014	1/6 (17%)
		Laminin_G_2	213..342	CDD:280389	33/135 (24%)
		Laminin_G_2	400..524	CDD:280389	32/135 (24%)
		EGF	553..584	CDD:278437	15/31 (48%)
		LamG	798..939	CDD:238058	40/158 (25%)
		DUF3844	963..>1005	CDD:289707	12/42 (29%)
		Laminin_G_2	1047..1176	CDD:280389	34/179 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.780