DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and nrxn3b

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001073516.1	Gene:	nrxn3b / 570698	ZFINID:	ZDB-GENE-070206-10	Length:	1403	Species:	Danio rerio

Alignment Length:	1567	Identity:	330/1567 - (21%)
Similarity:	550/1567 - (35%)	Gaps:	463/1567 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 TFAETGQGKTFIFAKNN--TFIQMDGDIIQTFQLRLCREISFQFRTRLPHGLLVYHNVKNPDRIN 296
            ||...|.|..|..::..  .:::.|.....        ::||||:|.:...|::|.:    |...
Zfish    16 TFLSLGLGLEFTGSEGQWARYLRWDASTRS--------DLSFQFKTAISDALVLYFD----DGGY 68

  Fly   297 LDPYALYVIVEKGQLKVVHVFGKHSTSVTVGESLNRDEWHSVMVRIDVHGARLIARVDNSQ--EE 359
            .|  .|.:.:|..:||:........|::|..:.:|...||  ...|..|..|.:..:|...  :|
Zfish    69 CD--FLLLSIEDAKLKLRFSVDCAETTITSDKMVNDSHWH--FATISRHNLRTVLALDGDSKVDE 129

  Fly   360 V-----YLKGLNHEYNYGVSTNLPSVVLVGGLSSEEKLHGVK-YITESFVGCIRNVVLSSGKAAS 418
            |     ::|.::..|..||..::.:..|.  |.:.:::...| .||:...|......|.|.|...
Zfish   130 VRPQRQFMKIVSDLYLGGVPQDIRTSALT--LPAAKEMPPFKGIITDLGYGNKVPTRLGSQKVRL 192

  Fly   419 DLLPIAPLVATKHENVNEG-CSDMCESRHNLCFVGSRCINHYGGISCDCFGTHYEGEHCD----- 477
            ::               || |::      |.|..|..|....|...|||..|.|.|.:|:
Zfish   193 EM---------------EGFCTE------NPCENGGSCSMADGEAYCDCSKTGYTGRYCNEAVNK 236

  Fly   478 ------------IYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGES 530
                        .....:.|.||:.|..|.:.  ::.:.||:..|:|.|:| :..:.|...:|:|
Zfish   237 TPGFAHMVKSPQAREENVATFRGSEYFCYDLS--QNPIQSSSDEITLSFKT-WQRNGLILHTGKS 298

  Fly   531 LKHQYIAASIKNQSVHVEMDFGDNVMSTV---LTDDLTRGYWHNLTILHEQRTVSIILDQQQKVL 592
            .  .|:..::|:.:|.:.::.|......:   :........||::.:....|..|.|.......|
Zfish   299 A--DYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDIKVTRNLRQHSGIGHAMVNKL 361

  Fly   593 ELPATASGNMLF---------------DPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISI 642
            ....|.|.:.:.               |...|.||.|......|....|||:|.||.|.|.:..|
Zfish   362 HCLVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDI 426

  Fly   643 LYELQR----GNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWP-INHAEEFNIKFDFRSSR 702
            ..||.|    .:||:...|.:..: .||...:.||::..|.|.:..| .|.....:|.||||:|.
Zfish   427 RLELSRLARIADPKMKLQGDIVFK-CENVPTLDPISFETAESFLGLPKWNTKRVGSISFDFRTSE 490

  Fly   703 PGAVLAYS--------DVTTSAGN--GFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATS-- 755
            |..::.::        |..:...|  .|:.:.|....|.  |:.|:.     |.|||: :||.
Zfish   491 PNGLILFTQGKPQDKKDSRSQRSNKVDFFAVELLDGHLY--LLLDMG-----SGTIKV-KATQNK 547

  Fly   756 -----WHSVEL--DYKLGEIRFTVDYRHT-------------LSQMY--GLTFNIGDKLIIGSSL 798
                 ||.|::  |.:.|.|  :|:.|.|             ...:|  ||..|..| ||:.:.|
Zfish   548 VNDGVWHHVDIQRDGRSGII--SVNSRRTPFTASGENEILDLEGNLYLGGLPDNRAD-LILPTEL 609

  Fly   799 KSAAM--GLVGCIRDIEINGHLIEPRHVVKTERVVG------EVALDNCNYIDPCKRPNTCEHGG 855
            .:|.:  |.||||||:.|:|...:.|.:.:.:.|.|      :|....|:       .|:|::.|
Zfish   610 WTAMLNYGYVGCIRDLFIDGRSKDIRQIAEAQNVGGIKSSCSKVTAKQCD-------SNSCKNNG 667

  Fly   856 KCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCE-ELALLGFTKSDVYLIDIDGNGVFPPAHVKCD 919
            .|....:|..|||..|||         :.:||| |.::|.:..| :|:     ..|.|
Zfish   668 ICKEGWNRFICDCTGTGY---------WDRTCEREASILSYDGS-MYM-----KVVMP------- 710

  Fly   920 FQSLENATKTIVEHNLPSQVDVR--SARESDFSFNIRYREFSPHMLQELIS-------------H 969
                     ||: |.....|.:|  |.|..........||.:..:..||.|             .
Zfish   711 ---------TII-HTEAEDVSLRFMSQRAFGLLMAATSRESADTLRLELDSGRVKLIVNLGKGPE 765

  Fly   970 SLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGNVKRGACPCSVNKTCVDPNQSCNCDVK 1034
            :||..|.:..:      :.||.. .|...||:                  |..||.      ||.
Zfish   766 TLYAGQKVNDN------DWHSVR-VTRRGKNI------------------KLMVDD------DVA 799

  Fly  1035 ENKWNSDEGYYQDPQSLGITNMY--FLQQKDMDDEAQGRITLGPLECVETNTQKYV--------- 1088
            |.:.|.|.      ..|..:|:.  .|.::.....|.... :|.|:.::.|...|:
Zfish   800 EGQMNGDH------TRLEFSNVETGILTERRFASTAPSNF-IGHLQGLKFNGLLYIDMCKNGDIE 857

  Fly  1089 -----------------VTFTTSQSYI---EVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPS 1133
                             |||.|..||:   .:..:....:.|.|:||.....:||.
Zfish   858 FCELNARFGMRSIVADPVTFKTKGSYLGLATLQAYSTMHLFFQFKTTSGDGFILFN--------- 913

  Fly  1134 FMVALTGDDQ-----------LTFTFTLSTGTTRELVINSHRRLNGGEWHKIWI--DYNQYH--- 1182
                 :||..           :.:.|.|..|.:. |..||...||..:||.:.|  |.:..|
Zfish   914 -----SGDGNDFIAVELVKGYIHYVFNLGNGPSL-LKGNSDSPLNDNQWHNVVITRDASNTHTLK 972

  Fly  1183 -----VRFMINTDYQMLDLLPEEEFGPFEGSMYIGGA---TFDLLKKLSV-KAGLIGCFRGLVVN 1238
                 |..::| ..:.|||         :|.:::.|.   .:..|.||.| :.|..||...:.:|
Zfish   973 VDAKSVSQVVN-GAKNLDL---------KGDLFVAGLGPNMYQNLPKLVVSREGFQGCLASMDLN 1027

  Fly  1239 GEILDIYSYMSVHLSEIIKDCK-PS--CVPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNI 1300
            |.:.|:.:.......:|.:.|: ||  |....|.|...|.:.|.:|.|.|:     :..:..|..
Zfish  1028 GRLPDLINDALFRSGQIERGCEGPSTTCQEDSCANMGVCIQQWENFTCDCS-----MTSYSGTQC 1087

  Fly  1301 NEKALTFI--------------NRESFLMRNYLSVG-ATPV-----------------ILMHGIN 1333
            |:...|:|              |.......:.|:|| :|.:                 |::|...
Zfish  1088 NDPGATYIFGKGGGLIMYTWPNNERPSTRTDRLAVGFSTTIKDGILVRIDSAPRLGDYIMLHIEE 1152

  Fly  1334 GERDVLKGILNQDLLINLRTYDTN----ALVLYA---------------NDHY---NNFVHLYIS 1376
            |:..|...|...|:.:...|.:.|    .:|.:.               |:|:   |:.:..:..
Zfish  1153 GKVCVTFNIGTVDISVKEMTTEVNDGKYHVVRFTRNGGNATLQVDNWPINEHFPSGNSDIERFQM 1217

  Fly  1377 LNREIVFLYN------YGDEIVNLTLLDDTLMASL------------------KSIQVAIVRGEQ 1417
            .|::|.|.|.      ..::...||:.:.....|:                  ..::|..:..|.
Zfish  1218 ANKKIPFKYTRPVEDWLHEKDRQLTIFNTQATISIGGNDRKRPYQGQLSGLYYNGLKVLNMAAEG 1282

  Fly  1418 ETRMHVNEHSVSIDRGTLLLDEYANKPWS-NPEKEVLSPHRPPAPPTEYFQFHVGGYDPANL--- 1478
            .|.:.:|        |::.|  ..:.|.| :|.:...|  .||...|.:.:      ....|
Zfish  1283 HTNIKIN--------GSVRL--VGDVPTSRSPSRTTTS--MPPEMSTTFIE------TTTTLSTT 1329

  Fly  1479 -LRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPNCQIKC---DAEPCKNGG 1539
             .|.....|.::                            |.:.::.:.:...   |.|.|..|.
Zfish  1330 TTRKQRSPPTIQ----------------------------TTDDIVSSAECSSDDEDLEECDGGH 1366

  Fly  1540 TCQEHFA 1546
            |.|..||
Zfish  1367 TAQSSFA 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389	31/143 (22%)
		EGF_CA	433..476	CDD:238011	14/43 (33%)
		Laminin_G_2	514..640	CDD:280389	31/143 (22%)
		Laminin_G_2	698..817	CDD:280389	43/154 (28%)
		EGF_CA	842..878	CDD:238011	11/35 (31%)
		Laminin_G_2	1112..1240	CDD:280389	35/152 (23%)
		EGF_CA	1256..1297	CDD:238011	11/43 (26%)
		Laminin_G_2	1351..1503	CDD:280389	29/202 (14%)
		LamG	1612..1733	CDD:304605
nrxn3b	NP_001073516.1	LamG	23..175	CDD:238058	36/169 (21%)
		EGF	198..229	CDD:278437	12/36 (33%)
		LamG	278..424	CDD:214598	33/148 (22%)
		LamG	481..630	CDD:214598	46/159 (29%)
		EGF_CA	658..691	CDD:238011	13/48 (27%)
		LamG	719..844	CDD:214598	31/162 (19%)
		Laminin_G_2	901..1029	CDD:280389	35/152 (23%)
		LamG	1093..>1212	CDD:238058	19/118 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1324..1348		4/51 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910