DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and cntnap1

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_694580.5	Gene:	cntnap1 / 566220	ZFINID:	ZDB-GENE-030916-2	Length:	1309	Species:	Danio rerio

Alignment Length:	1153	Identity:	286/1153 - (24%)
Similarity:	467/1153 - (40%)	Gaps:	193/1153 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFY 525
            |:..:.:|..|     |.|   ::...|...|:|...  :.|:.:.....:|.|:|...|..|.:
Zfish   161 GLRVEFYGCPY-----DSY---VMNFEGDDMVAYSFP--RGRMRTLQDHYALNFKTLEKDGILLH 215

  Fly   526 ASGESLKHQYIAASIKNQSVHVEMDFGD------NVMSTVLTDD-LTRGYWHNLTILHEQRTVSI 583
            :.|  |:...|...:|...:::.:..|.      |.|:|::..: |...:||.:||....|.::.
Zfish   216 SEG--LQGDSITLELKTGRLYLHISLGSSTVHNTNGMTTMMLGNLLDTQHWHYVTIKRFGRELNF 278

  Fly   584 ILDQQQKVLELPATASGNMLFDPEIYFGG-----GPELHKKKGLASHNNFVGSLKYVYYNDISIL 643
            .||.|.:...|..... ::..|.:||.||     .|.|..|.      ||.|.::.|:.|.|:|:
Zfish   279 TLDSQTETTILNGEFQ-HLDLDKKIYVGGVIEKDMPHLPGKV------NFRGCMENVFINGINII 336

  Fly   644 YELQRGNP---------KVHYHGVLEAEFVENEVNVIPITYPFATSHIWWP-INHAEEFNIKFDF 698
            |..|...|         |:||        :..::...|:|:....:::..| ........:||.|
Zfish   337 YMTQNQEPEIRLAPKKKKMHY--------MCRDLLWKPMTFAGPNNYLQLPGFFRKNRLAVKFKF 393

  Fly   699 RSSRPGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELDY 763
            ||.....:|.::......|:  .|:.|:..:::..|:...|..:..:...::|.. .||:|:|..
Zfish   394 RSWDYTGLLMFTRFADELGS--LELGLSEGQVNVTLMQPGNKRLRFAAGYRLNDG-FWHTVDLTA 455

  Fly   764 KLGEIRFTVDYRHTLSQMYGLTFNI--GDKLIIGSSLK--------SAAMGLVGCIRDIEINGHL 818
            |...:..|:|...:........|.:  ||:...|...|        :......||::.|.|:.
Zfish   456 KDNLLTITIDEDESSPLKITNPFMVRTGDRYFFGGCPKTNNTARCVTKLSRFHGCMQQIFIDD-- 518

  Fly   819 IEPRHV-VKTERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCH 879
             ||..: |..:|..|   |:.|..|...|.|. ||.|||.|:|....:...|.|.:|||.|:.||
Zfish   519 -EPVDIDVMLQRKWGRYAEILLGTCGITDRCS-PNPCEHEGRCIQSWNDFLCVCNNTGYKGEVCH 581

  Fly   880 FTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-S 943
            .:.||::||...|.|...|..|.||.|.:|...|..|.|   ::...|.|::|||......|. |
Zfish   582 NSVYRESCEAYRLNGKYWSGNYTIDPDLSGPLKPFTVYC---NMLQKTWTVIEHNRMKSTKVSGS 643

  Fly   944 ARESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL--ELHSATW-FTSSAKNLTVDF 1005
            ..:..:..:::|...|...:..|.:.||||.|:|::.||:::|  ..|...: :.....|.:.::
Zfish   644 TIDRPYIGDVQYVNASWDEVTALANTSLYCEQWIEFSCYKSRLLNTPHGRPYTYWIGRHNESHEY 708

  Fly  1006 LGNV--KRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEA 1068
            .|..  :.|.|.|:||:||.|....||||....:|:||:||......|.|..:..........||
Zfish   709 WGGAFPESGKCGCAVNQTCTDSKYWCNCDADYRQWHSDKGYLSFRDHLPIRRLVIGDTNRTGSEA 773

  Fly  1069 QGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAFSFRTTGEKAILLFQPPIRPH 1130
            |  .::|.|.|....:....:.| |..:|:..|.::.|   ||.|.|||  .:...:|......|
Zfish   774 Q--YSVGALYCHGDRSIWNTIAF-TKPTYLTFPTFKPGTSADITFHFRT--YRTYGVFVEASDDH 833

  Fly  1131 YPSFM-VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQML 1194
            ..:|: |.|....::.|.|.:..| .|.:.:.|.:.||..|||.:..:.|....|..:
Zfish   834 LRNFLRVELNSTTEVVFIFMVGDG-IRNVTLRSPKALNDNEWHYVEAEINVKLARLKV------- 890

  Fly  1195 DLLPEEEFGPFEGSMYIGGATFDLLKKLSVKAG------LIGCFRGLVVNGEILDIYSYMSVHLS 1253
            |.|| .....|.|..||   |.|..:.|.|.|.      .:||.|||.:||..:|:...:. ..:
Zfish   891 DFLP-PAIHKFPGQTYI---TMDFTQPLLVGAANHTLRPFLGCLRGLRMNGVPVDLEGKVD-ESA 950

  Fly  1254 EIIKDCKPSCVPS--PCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINEKALTFINRESFLMR 1316
            .|.::|..:|:.:  |||||.||.:.::|:.|.|||. ...|.:|..:|..
Zfish   951 GIRRNCTGACLNASIPCRNGGQCIDGYASYACDCNNT-GFDGYYCHLDIGA-------------- 1000

  Fly  1317 NYLSVGA--------TPV----------ILMH------GINGERDVLKGILNQDLLINLRTYDTN 1357
             :..|||        .|:          |..|      |.|...|        |:..:..|....
Zfish  1001 -FFDVGAWLRYDVRKEPISFDAWWANFWIEPHWHNFTLGYNTTTD--------DIEFSFSTLQAP 1056

  Fly  1358 ALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMH 1422
            |::||.:...|:::.:.:..:..:...|..|.......:.|..:.......            ::
Zfish  1057 AVLLYISSFSNDYIAVLLKKDGTLSMRYRLGIISYKFKMTDRNMADGFPHF------------VN 1109

  Fly  1423 VNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPA--PPTEYF---QFHVGGYDPANLLRPN 1482
            :..|:.::......:|     ||.    |.|.|...|.  .|...|   ...|||.| ..:.|.|
Zfish  1110 ITRHNYTVWTQVDYMD-----PWI----EKLVPGEIPRFDSPKSIFLGRVMEVGGVD-YEIQRHN 1164

  Fly  1483 VDAPALEGYIGCVRGLK--IGAQLIDLADINERNIAPTQEG--VLPNC 1526
              :|   |::||:.|::  |.|.|......|..|...|.:|  |..||
Zfish  1165 --SP---GFMGCISGVRYNIFAPLKAYFRPNVTNPPVTTQGYVVESNC 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	35/137 (26%)
		Laminin_G_2	698..817	CDD:280389	26/128 (20%)
		EGF_CA	842..878	CDD:238011	15/35 (43%)
		Laminin_G_2	1112..1240	CDD:280389	38/134 (28%)
		EGF_CA	1256..1297	CDD:238011	15/42 (36%)
		Laminin_G_2	1351..1503	CDD:280389	30/158 (19%)
		LamG	1612..1733	CDD:304605
cntnap1	XP_694580.5	FA58C	23..169	CDD:214572	1/7 (14%)
		FA58C	38..168	CDD:238014	1/6 (17%)
		Laminin_G_2	204..333	CDD:280389	35/137 (26%)
		LamG	366..517	CDD:238058	30/153 (20%)
		EGF	548..578	CDD:278437	13/30 (43%)
		FReD	588..>632	CDD:294064	15/46 (33%)
		LamG	791..936	CDD:238058	45/159 (28%)
		EGF_CA	960..994	CDD:238011	14/34 (41%)
		Laminin_G_2	1050..1178	CDD:280389	29/154 (19%)
		4.1m	1260..1278	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820