DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and nrxn3a

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:XP_021322866.1 Gene:nrxn3a / 563598 ZFINID:ZDB-GENE-070206-9 Length:1692 Species:Danio rerio


Alignment Length:2021 Identity:405/2021 - (20%)
Similarity:683/2021 - (33%) Gaps:733/2021 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 EISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQLKVVHVFGKHSTSVTVGESLNRDE 334
            ::||||:|.:...|::|.:    |....|  .|.::|.:|:|::........|:|...:.:|...
Zfish    46 DLSFQFKTDVSTALILYFD----DGGFCD--FLQLMVVEGKLQLQFSIDCAETTVVSDKRVNDSS 104

  Fly   335 WHSVMVRIDVHGARLIARVDNSQEEVYLKGLNHEYNYGVSTNLPSVVLVGGLSSEEKLHGVKYIT 399
            |||  ..:..:..|.:..:|...:...::.| .:|     ..:.|.:.:||:..:.::..:...|
Zfish   105 WHS--ATLSRYNLRTVLGLDGVSKWAEVRPL-RQY-----MKIVSDLFLGGVPQDIRISVLTLPT 161

  Fly   400 ----ESFVGCIRN--------VVLSSGKAASDLLPIAPLVATKHENVNEGCSDMCESRHNLCFVG 452
                ..|.|.||.        ::|||.:...|:               ||   :|  ..|.|..|
Zfish   162 VKDLPPFKGIIRELKYNSKEPILLSSQRVRMDI---------------EG---IC--MENPCENG 206

  Fly   453 SRCINHYGGISCDCFGTHYEGEHCD---------------------IYTATIITLRGASYVSYRI 496
            ..|....|...|||..|.|.|..|:                     .....:.|.||:.:..|.:
Zfish   207 GTCSVVDGEPLCDCSKTEYVGRFCNEEANNIPGFAHMMMADQAKGKAREENVATFRGSEFFCYDL 271

  Fly   497 YDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV-- 559
            .  ::.:.||:..|:|.|:| :..:.|...:|:|.  .|:..::|:.:|.:.::.|......:  
Zfish   272 S--QNPIQSSSDEITLSFKT-WQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAFEAIVE 331

  Fly   560 -LTDDLTRGYWHNLTIL----------HEQRTVSI--ILDQQQKVLELPATASG------NML-F 604
             :........||::.:.          |...|:|:  ||           |.:|      .|| .
Zfish   332 PVNGKFNDNSWHDVKVTRNLRQHSGIGHAMVTISVDGIL-----------TTTGYTQEDYTMLGS 385

  Fly   605 DPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQR----GNPKVHYHGVLEAEF-V 664
            |...|.||.|......|....|||:|.||.|.|.:..|..||.|    .:||:...|  :..| .
Zfish   386 DDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIVDPKMKIQG--DVVFKC 448

  Fly   665 ENEVNVIPITYPFATSHIWWP-INHAEEFNIKFDFRSSRPGAVLAYS--------DVTTSAGN-- 718
            ||...:.||::....::|..| .|.....:|.||||::.|..::.::        |..:....  
Zfish   449 ENVATLDPISFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKV 513

  Fly   719 GFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-------SWHSVEL--DYKLGEIRFTVDY 774
            .|:.:.|....|.  |:.|:.     |.|||: :||       :|:.|::  |.:.|.|  :|:.
Zfish   514 DFFAVELLDGSLY--LLLDMG-----SGTIKV-KATQNKVNDGAWYHVDIQRDGRSGTI--SVNS 568

  Fly   775 RHT-------------LSQMY--GLTFNIGDKLIIGSSLKSAAM--GLVGCIRDIEINGHLIEPR 822
            |.|             ...||  ||..:.| .||:.:.|.:|.:  |.||||||:.|:|...:.|
Zfish   569 RRTPFTASGENEILDLEGDMYLGGLPDSRG-SLILPTELWTAMLNYGYVGCIRDLFIDGRSKDIR 632

  Fly   823 HVVKTERVVGEVALDNCNYID-------PCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHF 880
            .:.:.:...|  ...:||.:.       |||....|:.|...|:      |||..|||       
Zfish   633 QIAEAQNGAG--IKPSCNKMSGKQCDSYPCKNKGLCKEGWNRFI------CDCTGTGY------- 682

  Fly   881 TKYRKTCE-ELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSA 944
              :.:||| |.::|.:..| :|:     ..|.|                 .|.|.....|.:|  
Zfish   683 --WSRTCEREASILSYDGS-MYM-----KVVMP-----------------TVMHTEAEDVSLR-- 720

  Fly   945 RESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGN- 1008
                                 .:|...|              .|..||....||..|.::..|: 
Zfish   721 ---------------------FMSQRAY--------------GLLMATTSRDSADTLRLELDGSR 750

  Fly  1009 VKRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRIT 1073
            ||     .:||..|:    ..||       ||.:|    |::|      :..||..|:       
Zfish   751 VK-----LTVNLDCI----RINC-------NSSKG----PETL------YAGQKLNDN------- 782

  Fly  1074 LGPLECVETNTQKYVVTFTTSQSYIEVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVAL 1138
                   |.:|.:.:               |:|.   |::                        |
Zfish   783 -------EWHTVRVI---------------RRGK---SYK------------------------L 798

  Fly  1139 TGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLLPEEEFG 1203
            |.||.:          ....::..|.||   |:|         ::...:.|:.:.:.::|....|
Zfish   799 TVDDDV----------AEGQMVGDHTRL---EFH---------NIETGVMTERRFVSMIPSSFIG 841

  Fly  1204 -----PFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSC 1263
                 .|.|.:||     ||.|                 ||:|                      
Zfish   842 HLQSLKFNGLLYI-----DLCK-----------------NGDI---------------------- 862

  Fly  1264 VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETN-------INEKALTFINRESFLMRNYLSV 1321
                                          :|||.|       |....:||.::.|     |||:
Zfish   863 ------------------------------DFCELNARFGMRSIIADPVTFKSKNS-----YLSL 892

  Fly  1322 GATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYN 1386
            .               .|:...:..|....:|...:..:|:.:...::|:.:.: :...|.:::|
Zfish   893 A---------------TLQAYTSMHLFFQFKTTSADGFILFNSGDGSDFIAVEL-VKGYIHYVFN 941

  Fly  1387 YGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNE-HSVSIDRG-----TLLLDEYANKPW 1445
            .|:                   ...:::|..|..:|.|: |:|.|.|.     ||.:|..|....
Zfish   942 LGN-------------------GPNVIKGNSERALHDNQWHNVVITRDNSNVHTLKVDAKAVSQV 987

  Fly  1446 SNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNV--DAPAL----EGYIGCVRGLKIGAQL 1504
            .|..|.:         ..:...|..|       |.||:  :.|.|    ||:.||:..:.:..:|
Zfish   988 VNGAKNL---------DLKGDLFIAG-------LGPNMYNNLPKLVASREGFKGCLASVDLNGRL 1036

  Fly  1505 IDLADINE---------------RNIAPTQEGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDC 1554
            .||  ||:               :|.....:..|......|..:.|.|.|.|.:.:...  ||||
Zfish  1037 PDL--INDALFRSGQIERGCEASKNELGFTKADLKGPSTTCQEDSCANMGICIQQWENY--TCDC 1097

  Fly  1555 EHTSFLGEFCSEEKGADFSGESTLQRKF-----ELPGTGRVDYVRLQLAFSSFDLRRANRIMLLM 1614
            ..||:.|..|::.......|:......|     |.|.| |.|  ||.:.||: .|:  :.|::.:
Zfish  1098 SMTSYTGTHCNDPGTTYIFGKGGGLISFNWPANERPST-RTD--RLTVGFST-SLK--DGILIRI 1156

  Fly  1615 QTEAERSYYLLLAI------------TSDGYLQLEEDRDNGQTVGARIDRNFLNSARHSVYYVRN 1667
            .:......||:|.|            |:|..:|......|             :...|.|.:.||
Zfish  1157 DSAPGLGDYLMLHIEQGKIGVTFNIGTADITVQESSTAVN-------------DGKYHVVRFTRN 1208

  Fly  1668 GTQSQLFID----REQVPLSEFAARVLTTGGDAGSNRVQIGGINSTDSRFAVFKSYSGCLSNIYI 1728
            |..:.|.:|    .|..|           .|::.:.|:|:.      ::...|| |:        
Zfish  1209 GGNATLQVDNWAINEHFP-----------SGNSDNERIQMA------NKKIPFK-YA-------- 1247

  Fly  1729 QVNGHVMKPLEEYMLFTKSGADNITVINPQGVRSAQCNAKFDVSEQPTQEP-------------- 1779
                   :|:||::   :.....:|:.|.|        |...:.....:.|              
Zfish  1248 -------RPVEEWL---QEKGRQLTIFNTQ--------ATITIGGSDRKRPFQGQLSGLYYNGLK 1294

  Fly  1780 MVNVSMIPEP---------WVEEPP----ARVPYIPRFVYDENKQEDSTQVVFLTLTSVFVIIVI 1831
            ::|::....|         .|.|.|    ||...:|        .|.||..:..|.|        
Zfish  1295 VLNMAAQGNPNIKINGSVRLVGEVPAAGSARTTALP--------PEMSTTFIETTTT-------- 1343

  Fly  1832 CCLLEVYRSHLAYKKRIERETDEDIIWSKEQAT---KMHESPGVKAGLLGGVTAGSGNGLPPYTY 1893
             ......|.|   :.....:|.:|::.|.|.::   ...|..|...|.|          :.|...
Zfish  1344 -MSTTTTRKH---RTPPTIQTTDDMVSSAECSSDDEDFAECEGHAGGEL----------VFPVIV 1394

  Fly  1894 K---ALPQ-EDKKPGNGAP----LVGILKNGSATPSQPGTPTALSKNGDIASRIEEEEEEEDEAP 1950
            |   .||. ..:.|....|    ::...|...:..::.|.| .||..|  :....::::::|:..
Zfish  1395 KDPLELPSVATRTPSIPFPPTLTIIETTKESLSMATEAGVP-CLSDGG--SDDCGDDDDDDDDDG 1456

  Fly  1951 AQKAAEKSGE---NEEPPAKD----TTASEIKES-----------QAQPPEQLAKD--------- 1988
            ...:...|||   :..||..|    ||.|.:.:.           :|..|:..:||         
Zfish  1457 LMISGYGSGEAYDSNLPPTDDEDFYTTFSLVTDKTLSSSTFEGGYKAHAPKWGSKDFRPNKVFDS 1521

  Fly  1989 --TTDASAAPKASKETEAQAEPSEPSSQLNSAQNGQLAQMEQAARGDEVQVPSLPHPIQP-PDAI 2050
              ||.||.:||.|:.|.....|..|:.::|..:                        ::| ||.:
Zfish  1522 GRTTTASFSPKLSRSTTTSTPPKLPAGKMNHRE------------------------LKPQPDIV 1562

  Fly  2051 FMPNLP 2056
            .:| ||
Zfish  1563 LLP-LP 1567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 28/147 (19%)
EGF_CA 433..476 CDD:238011 14/42 (33%)
Laminin_G_2 514..640 CDD:280389 34/147 (23%)
Laminin_G_2 698..817 CDD:280389 40/154 (26%)
EGF_CA 842..878 CDD:238011 12/42 (29%)
Laminin_G_2 1112..1240 CDD:280389 20/132 (15%)
EGF_CA 1256..1297 CDD:238011 1/40 (3%)
Laminin_G_2 1351..1503 CDD:280389 31/163 (19%)
LamG 1612..1733 CDD:304605 23/136 (17%)
nrxn3aXP_021322866.1 LamG 23..178 CDD:238058 31/145 (21%)
EGF 198..>221 CDD:306513 8/24 (33%)
LamG 282..421 CDD:214598 36/152 (24%)
LamG 478..627 CDD:214598 43/159 (27%)
EGF_CA 655..688 CDD:238011 13/47 (28%)
LamG 716..850 CDD:214598 44/274 (16%)
Laminin_G_2 907..1035 CDD:308045 31/163 (19%)
EGF_CA 1075..1107 CDD:238011 12/33 (36%)
LamG 1113..1291 CDD:238058 44/240 (18%)
Syndecan 1618..>1653 CDD:307260
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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