DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axo and cntnap2b

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001289171.1	Gene:	cntnap2b / 563345	ZFINID:	ZDB-GENE-070912-26	Length:	1315	Species:	Danio rerio

Alignment Length:	1169	Identity:	277/1169 - (23%)
Similarity:	474/1169 - (40%)	Gaps:	223/1169 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFY 525
            |:..:.:|       | .|.|.:|:..|...:|||....|.::....  |||.|:|:..|..|.:
Zfish   167 GLRVEIYG-------C-AYWADVISFDGQGVISYRFRQKKMKILKDV--ISLKFKTSKGDGVLLH 221

  Fly   526 ASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV----------LTDDLTRGYWHNLTILHEQRT 580
              ||..:..||...::...:.::::.|.|...::          |.||   ..||::.|...:|:
Zfish   222 --GEGQQGDYITLELRRAKLQLQINLGSNQYGSIQGHTSASSGSLLDD---DQWHSVLIERYRRS 281

  Fly   581 VSIILDQQQKVLELPATASG---NMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISI 642
            ::..|||.::...    .:|   ::..|.||.|||.| :..|.......|::|.::.::||..:|
Zfish   282 INFTLDQHKQSFR----TNGEFDHLDLDYEITFGGMP-VSAKPSSGGRENYIGCMEAIHYNGDNI 341

  Fly   643 LYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWP-INHAEEFNIKFDFRSSRPGAV 706
            ....:|  .||.........|...|....|..:. :||.:..| ...|:..:::..||:..|..:
Zfish   342 TNLARR--RKVDTSSFHNLTFSCTESRTFPAFFN-STSSLQLPGRTDADTVSVRLQFRTWNPSGL 403

  Fly   707 LAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-----SWHSVE---LDY 763
            |.::.:..    |..|:.|...|::..:...:..|    |.:.|:..:     .||||.   |:
Zfish   404 LFFTPLMP----GGVEVSLVEGKVTVHIYVTLGKN----TRVDISSGSGLNDGQWHSVHFLALE- 459

  Fly   764 KLGEIRFTVDYRHTLSQMYGLTFNIGDKLIIG-----SSLKSAAMGLVGCIRDIEINGHLIEPRH 823
            .:..:....|...|:.....:....|.....|     :.|..:.....||::.|.::...::.:.
Zfish   460 SIAMLTINGDEMSTVRAALPMQIRTGGDYFFGGYFPRTDLSPSQRSFQGCMQLIHVDDQFMDLQS 524

  Fly   824 VVKTERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRK 885
            |  .:.|:|   .|:||.|..||.|. ||.|||||||...:|...|.|:.|||.|..||.:.|.:
Zfish   525 V--EQGVLGSFENVSLDMCAIIDRCV-PNHCEHGGKCSQTEDTFKCACEGTGYSGATCHNSVYEQ 586

  Fly   886 TCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQ--VDVRSARESD 948
            :|||...|| ..||.|.||.||:|...|..|.|:.:  |:...|.:.::||:|  |...|..|..
Zfish   587 SCEEYKHLG-RSSDTYWIDPDGSGSLEPFRVTCNMK--EDKVWTTIANDLPAQSSVSAGSVPEDK 648

  Fly   949 FSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL------ELHSATWFTSSAKNLTVDFLG 1007
            ....:.| ..|...:..:.|.:..|.|::.|.||::||      ::..:|::...         |
Zfish   649 TVLTLNY-SMSTEQVNAITSSAELCEQHVSYMCYKSQLLRVPSPDVPPSTYWVGR---------G 703

  Fly  1008 NVKR----GA------CPCSVNKTCVDPNQSCNCDVKENKWNSDEG--YYQD--PQS-LGITNMY 1057
            |.|.    |:      |.|.:.:.|.||...||||....:|..|.|  .|:|  |.| :.:.::|
Zfish   704 NEKHFYWGGSGPGVQKCACGIERNCTDPRYYCNCDADLRQWKEDAGMLMYKDHLPVSQVVVGDIY 768

  Fly  1058 FLQQKDMDDEAQGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKA 1119
                   ...::.::|:|||.|..........:|.|..||:..|..:   ..|::|.|:|:....
Zfish   769 -------RSGSEAKLTVGPLRCQGDRHYWNAASFNTPASYLHFPTLQAETSADVSFYFKTSASHG 826

  Fly  1120 ILLFQPPIRPHYPSFM-VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHV 1183
            :.|    .....|.|: :.|:....::|:|.:..|.. ||.:.|...||..:||::..:.|....
Zfish   827 VFL----ENLGNPDFIRLELSSASVVSFSFDVGNGLV-ELSVRSSTPLNDDQWHRVEAERNIKEA 886

  Fly  1184 RFMINTDYQMLDLLPEEEFGPFEGSMYIGGATFDLLKKLSVKA-----GLIGCFRGLVVNGEILD 1243
            ...::..|:.....|.:           |.....|..:|.|.|     |.:||.|.|.|||..||
Zfish   887 VLRVDKLYREARSAPPQ-----------GHTRLRLFSQLFVGASGGQRGFLGCIRSLKVNGVTLD 940

  Fly  1244 IYSYMSVHLSEIIKDCKPSC------VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINE 1302
            :..     .:::....||.|      ....|:||.:|.|.::.:.|.|:.. |..|.||    |:
Zfish   941 LEG-----RAKVTPGVKPGCSGHCSSYGMHCQNGGKCIEKYNGYSCDCSQT-AFDGPFC----ND 995

  Fly  1303 KALTFINRESFLMRNYLSVGAT--PVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYAND 1365
            ....:....:.:..:.:|..:|  |. |..|.:....::..:.:::|..:..|.:|.|:.:|.:.
Zfish   996 DVGGYFESGTLVRFDLMSESSTSSPA-LKEGESAVLGIVGNLTHEELSFSFSTSNTPAVPIYISS 1059

  Fly  1366 HYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSI 1430
            ...:::.:.:..|..:...||.|.       |.:....||....:|  .|:        .|:|:|
Zfish  1060 KTQDYLAVVLRHNGTLQIRYNLGG-------LKEPFSISLNHRNMA--NGQ--------PHNVNI 1107

  Fly  1431 DRG----TLLLDEYANKPWSNPEKEVLSPHRPPAPPTEY---------FQFHVGGYDPANLLRPN 1482
            .|.    .|.:|.|....::.||          |..||:         ..|..|..||..:.|.|
Zfish  1108 SRQERHIQLQVDHYPTASYTLPE----------ASDTEFNLVKTIFLGKVFETGQIDPVLIERYN 1162

  Fly  1483 VDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQ------------EGVLPNCQIKCDAEP 1534
            .     .|::||            |:.:....|:|.:            :|||  .:..|.|.|
Zfish  1163 T-----PGFVGC------------LSRVQFNRISPLKAALRSGLSTASIQGVL--VESNCGASP 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	2/14 (14%)
		Laminin_G_2	514..640	CDD:280389	33/138 (24%)
		Laminin_G_2	698..817	CDD:280389	24/131 (18%)
		EGF_CA	842..878	CDD:238011	19/35 (54%)
		Laminin_G_2	1112..1240	CDD:280389	31/133 (23%)
		EGF_CA	1256..1297	CDD:238011	13/46 (28%)
		Laminin_G_2	1351..1503	CDD:280389	34/164 (21%)
		LamG	1612..1733	CDD:304605
cntnap2b	NP_001289171.1	FA58C	33..174	CDD:238014	1/6 (17%)
		FA58C	44..175	CDD:214572	2/14 (14%)
		Laminin_G_2	210..338	CDD:280389	32/137 (23%)
		Laminin_G_2	395..518	CDD:280389	24/131 (18%)
		EGF_CA	544..579	CDD:238011	19/35 (54%)
		LamG	792..935	CDD:238058	36/158 (23%)
		EGF_CA	959..993	CDD:238011	9/34 (26%)
		LamG	1040..1177	CDD:214598	36/180 (20%)
		4.1m	1266..1284	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.780