DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and cntnap2a

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_009295628.1	Gene:	cntnap2a / 559157	ZFINID:	ZDB-GENE-120328-3	Length:	1326	Species:	Danio rerio

Alignment Length:	1160	Identity:	282/1160 - (24%)
Similarity:	479/1160 - (41%)	Gaps:	203/1160 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   468 GTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLK 532
            |..:|...|. |.|.:|...|...:|||....|.::....  |:|.|:|:..:..:.:  ||..:
Zfish   170 GLRFEIYGCP-YWADVINFDGQGVISYRFKMKKMKILKDV--IALKFKTSESEGVILH--GEGQQ 229

  Fly   533 HQYIAASIKNQSVHVEMDFGDN----------VMSTVLTDDLTRGYWHNLTILHEQRTVSIILDQ 587
            ..||...::...:.::::.|.|          |.|..|.||   .:||::.|...:|.|:..|||
Zfish   230 GDYITLELRRGRLLLQINLGSNQHGSILGHTSVTSGSLLDD---HHWHSVVIERYRRNVNFTLDQ 291

  Fly   588 QQKVLELPATASG---NMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRG 649
            ..:...    .:|   ::..|.|:.|||.| ...|..:....||.|.::.:.||..:|. :|.|
Zfish   292 HTQHFR----TNGEFDHLDLDYELTFGGMP-YSGKPVIGGRRNFKGCMESINYNGENIT-DLAR- 349

  Fly   650 NPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAEEF-NIKFDFRSSRPGAVLAYSDVT 713
            ..|:.........|...:.:..|:.:. .||.:..|....... ::.|.|||..|..:|.:|
Zfish   350 RKKLDTSSFRNLTFSCVDTHTFPVFFN-GTSFLQLPGRRDHNMVSVGFQFRSWNPSGLLLFS--- 410

  Fly   714 TSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-------SWHSVELDYKLGEIRFT 771
             |..:|..|:.|...|::..:      |||....::::.|:       .||.|....|......|
Zfish   411 -SLADGMLELALNDGKVTAHI------NVTQQKNMRVDIASGSGLNDGEWHDVRFLAKENFAMLT 468

  Fly   772 VD-----YRHTLSQMY---GLTFNIGDKLIIGSSLKSAA----MGLVGCIRDIEINGHLIEPRHV 824
            :|     ...|.|.:.   |.|::.|     |..|::.|    ....||::.|:::..|.: ...
Zfish   469 IDGDEASAVRTNSPVLITTGSTYHFG-----GYFLRTRASPIQRSFQGCMQLIQVDDQLAD-LTA 527

  Fly   825 VKTERV--VGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTC 887
            |:..|:  ...|:||.|..||.| .||.|||||:|....|..||.|..|||.|..||.:.|.::|
Zfish   528 VEQGRIGAFENVSLDMCAIIDRC-MPNHCEHGGRCSQTWDSFTCTCDGTGYTGATCHTSVYEQSC 591

  Fly   888 EELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-SARESDFSF 951
            |....|| ..||.|.||.||:|...|..|.|:.  .|:...|.|.:|||:|..|. |:||.....
Zfish   592 EAYKHLG-RSSDAYWIDPDGSGPLGPFKVICNM--TEDKVWTTVVNNLPAQTAVTGSSRERRTVL 653

  Fly   952 NIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWFTSSAKNLTVDFLGNVKR 1011
            .:.| ..|...:..:.:.:.:|.|::.|.|..::| |::.     ||:...         ||.|.
Zfish   654 QLNY-SASMEQVTAITNSAEHCEQHVSYACRMSRL-LNTPDGTPYTWWVGR---------GNEKH 707

  Fly  1012 ----GA------CPCSVNKTCVDPNQSCNCDVKENKWNSDEG--YYQD--PQS---LGITNMYFL 1059
                |:      |.|.:.:.|.|....||||..:.:|..|.|  .|:|  |.|   :|.||.
Zfish   708 FYWGGSAPGIQKCACGIERNCSDSKYYCNCDADQKQWRDDSGLLVYKDHLPVSQVAVGDTNR--- 769

  Fly  1060 QQKDMDDEAQGRITLGPLECVETNTQKYVVTFTTSQSYIE---VPGWRKGDIAFSFRTTGEKAIL 1121
                  ..::.::|:|||.|....:.....:|.|..||:.   ..|....||:|.|:|:....:.
Zfish   770 ------PGSEAKLTVGPLRCHGDRSYWNAASFNTPSSYLHFSTFQGETSADISFYFKTSAPYGVF 828

  Fly  1122 L-------FQPPIRPHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYN 1179
            |       |   ||....|.||       ::|:|.:..|.. ||.::|...||..:||::..:.|
Zfish   829 LENLGNTDF---IRLELKSPMV-------VSFSFDVGNGPV-ELNVHSPTPLNDDQWHRVSAERN 882

  Fly  1180 QYHVRFMINTDYQMLDLLPEEEFGPFE--GSMYIGGATFDLLKKLSV--KAGLIGCFRGLVVNGE 1240
            .......::..|:.:...|.:.....|  ..:|:|.......:..:.  :.|.:||.|.|.:||.
Zfish   883 TKEAILQLDQKYKEIRPAPTQGHTRLELYSQLYVGKPALWACQDSAAGGQRGFLGCIRSLKMNGV 947

  Fly  1241 ILDIYSYMSVHLSEIIKDCKPSC------VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETN 1299
            .||:     ...:::....||.|      ....||||.:|.|.::.:.|.|... |:.|.||..:
Zfish   948 TLDL-----EERAKVTPGVKPGCSGHCTSFGMYCRNGGKCVEKYNGYSCDCTTT-AYDGPFCSKD 1006

  Fly  1300 INE--KALTFINRESFLMRNYLSVGAT--PVILMHGINGERDVLKGILNQDLLINLRTYDTNALV 1360
            :..  :|.|.:...  |:...|:..::  ...::|.:..|.:    :.::||..:..|..:.:|:
Zfish  1007 VGGFFEAGTLVKYN--LVPEVLAAASSLDEKSIIHNLPVETN----LTHEDLTFSFSTSTSPSLL 1065

  Fly  1361 LYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTL-LDDTLMASLKSIQVAIVRGEQETRMHVN 1424
            :|.:....:::.:.:..|..:...|:.|......|: :|...:|:.:...|.|.|.|::..:.
Zfish  1066 VYVSSKTQDYMAVVLRHNGTLQLRYSLGGLREPFTIDIDQRNLANGQPHTVNISRVERDIEVQ-- 1128

  Fly  1425 EHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYF---------QFHVGGYDPANLLR 1480
                        ||.|....:|.||          |..|::.         .|..|..||..:.:
Zfish  1129 ------------LDHYPAVTYSLPE----------ASDTQFTLVKSLFLGKVFETGYIDPVLIEK 1171

  Fly  1481 PNVDAPALEGYIGCVRGLKIGAQLIDLADINER-NIAPTQEGVLPNCQIKCDAEP 1534
            .|.     .|::||:..::..:.....|.:..| :::.:.:|.|  .:..|.|.|
Zfish  1172 YNT-----PGFVGCLSRVQFNSIAPLKAALRSRGSVSVSHQGKL--VESNCGASP 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	2/7 (29%)
		Laminin_G_2	514..640	CDD:280389	34/138 (25%)
		Laminin_G_2	698..817	CDD:280389	32/137 (23%)
		EGF_CA	842..878	CDD:238011	19/35 (54%)
		Laminin_G_2	1112..1240	CDD:280389	31/138 (22%)
		EGF_CA	1256..1297	CDD:238011	14/46 (30%)
		Laminin_G_2	1351..1503	CDD:280389	29/161 (18%)
		LamG	1612..1733	CDD:304605
cntnap2a	XP_009295628.1	FA58C	31..178	CDD:214572	2/7 (29%)
		FA58C	46..177	CDD:238014	2/6 (33%)
		Laminin_G_2	213..342	CDD:280389	34/138 (25%)
		LamG	372..519	CDD:238058	37/162 (23%)
		EGF_CA	547..582	CDD:238011	19/35 (54%)
		LamG	792..945	CDD:238058	38/163 (23%)
		EGF_CA	969..1003	CDD:238011	10/34 (29%)
		Laminin_G_2	1064..1189	CDD:280389	28/153 (18%)
		4.1m	1277..1295	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920