DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and nrxn1b

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001277105.1	Gene:	nrxn1b / 555686	ZFINID:	ZDB-GENE-070206-3	Length:	1475	Species:	Danio rerio

Alignment Length:	1353	Identity:	310/1353 - (22%)
Similarity:	499/1353 - (36%)	Gaps:	370/1353 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 EISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQLKV-VHVFGKHSTSVTVGESLNRD 333
            |:||..:|...:|||||.:    |....|...|:|.|  |:|:: ..:|...||.|....::|.:
Zfish    53 EMSFSVKTTHLNGLLVYFD----DEGFCDFLELHVHV--GKLRLCFSIFCAESTCVLSDVAINDN 111

  Fly   334 EWHSVMVRIDVHGARLIARVDNSQEEVY-----LKGLNHEYNYGVSTNLPSVVLVGGLSSEEKLH 393
            .||||.:..:.....||...:...|||.     :...:|.:..|:.:.|.||.|  .|:|:.
Zfish   112 RWHSVSIMRNFRNTTLIVDDEVKWEEVKSQRRDMTVFSHLFLGGIPSELRSVSL--QLTSKT--- 171

  Fly   394 GVKYITESFVGCIRNVVLSSGKAASDLLPIAPLVATKHENVNEGCSDMCESRHNLCFVGSRCINH 458
             ||..| ||.|.|.:|      ..:|..|.....|..||       |:|.| .|.|..|..|...
Zfish   172 -VKDHT-SFTGWIMDV------KVNDSEPAIISSAGVHE-------DLCGS-ENTCLNGGVCSVV 220

  Fly   459 YGGISCDCFGTHYEGEHCDIYTATII-----------TLRGASYVSYRIYDWKDRVHSSTRRISL 512
            ....:|||..|.|:|:.|....|.::           |.||:.|..|.:.  .:.:.||:..|:|
Zfish   221 EDKPTCDCSQTGYQGKDCSEGLAHLMMLDRGMEEYVATFRGSEYFCYDLS--LNPIQSSSDEITL 283

  Fly   513 MFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV---LTDDLTRGYWHNLTI 574
            .||| ...:.|...:|:..  .|:..::||.:|.:.::.|......:   :........||::.:
Zfish   284 SFRT-LQRNGLMLHTGKIA--DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNEWHDVKV 345

  Fly   575 LHEQR----------TVSI--ILDQQQKVLELPATASG------NML-FDPEIYFGGGPELHKKK 620
            |...|          |:|:  ||           |.:|      .|| .|..:|.||.|......
Zfish   346 LRNLRQHSGVGYAMVTISVDGIL-----------TTTGYTQEEYTMLGSDDFLYVGGSPSTADLP 399

  Fly   621 GLASHNNFVGSLKYVYYNDISILYELQR----GNPKVHYHGVLEAEFVENEVNVIPITY----PF 677
            .....|||:|.|:.|.|.:.....||.|    |:||:..|||: |...|:...:..||:    .|
Zfish   400 ESPVSNNFMGCLREVVYKNNDAELELSRLAYQGDPKLQIHGVV-AFKCESVATLDAITFETPESF 463

  Fly   678 ATSHIWWPINHAEEFNIKFDFRSSRPGAVLAYSDVTTSAGN-----------GFWEIRLTSDKLS 731
            .|...|   |..:..:|.||||::.|..:|.:|.......|           .|:.|.:. |.|.
Zfish   464 LTLPKW---NAKKSGSISFDFRTTEPNGLLLFSCGRAKQHNKEAKSPVTLKVDFFAIEML-DGLL 524

  Fly   732 FDLVPDVNNNVTHSTTIKINRATS---WHSVEL--DYKLGEIRFTVDYRHTLSQMYGLTFNIGDK 791
            : |:.|:.:..|  .|:.:|:..:   |:.|:.  |.|.|.|.........|........::.|.
Zfish   525 Y-LLLDMGSGTT--KTLALNKKVNDGEWYHVDFQRDGKSGTISINSVRTPYLCPGDSELLDLDDP 586

  Fly   792 LIIGSSLKSAA--------------MGLVGCIRDIEINGHLIEPRHVVKTERVVGEVALDNCN-- 840
            |.:|...:|::              .|.|||:||:.|:|..::.|...:.:|..|  ...:|.
Zfish   587 LYLGGVPESSSGTVFPTGAWSALLNYGYVGCVRDLFIDGRSVDVRRAAELQRAAG--VKPSCGKE 649

  Fly   841 -----YIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELALLGFTKSDV 900
                 ..:||.....|..|.      .|..|||..||::|.:|                  :.|.
Zfish   650 PPGKCVSEPCLNRGVCREGW------SRYICDCTGTGFLGHSC------------------ERDA 690

  Fly   901 YLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYREFSPHMLQE 965
            .::..||:     ..:|..|.:   |..|..|       ||          ::|:|....:.:.
Zfish   691 TILSFDGS-----KFLKVQFSA---AMHTEAE-------DV----------SLRFRSLRAYGVL- 729

  Fly   966 LISHSLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGNVKRGACPCSVNKTCVDPNQSCN 1030
            :.|.|.:.|     |..|.:||        :....|||:.  :..|..|..|.....:...|:.|
Zfish   730 MASTSTHTT-----DTLRLELE--------AGRVRLTVNL--DCNRINCTTSKGPESLFAGQNLN 779

  Fly  1031 CDVKENKWNSDEGYYQDPQ-SLGITNMYFLQQKDMDDEAQ--------GRIT------------L 1074
                :::|::.....:... .|.:.::..:..:...|..|        |.||            :
Zfish   780 ----DDEWHTVRVIRRGKSLKLSVDDLPTVDGEIPGDHTQLEFHNIETGIITGKRQLPTMPSNFI 840

  Fly  1075 GPLECVETNTQKYV--------------------------VTFTTSQSYIEVP---GWRKGDIAF 1110
            |.|:.:..|.:.|:                          |||.:..||:.:|   .:....:.|
Zfish   841 GHLQSLMFNGKPYIDLCKNGDIDYCQTNAPIGFKSIIADPVTFKSCSSYVTLPSLQAYYYMYLFF 905

  Fly  1111 SFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQ-----------LTFTFTLSTGTTRELVI-NSH 1163
            .|:||....::|:.              :||..           |.:...|..|.  .|:. ||.
Zfish   906 QFKTTSADGLILYN--------------SGDGNDFIAVELVKGYLHYISDLGNGA--HLIKGNSI 954

  Fly  1164 RRLNGGEWHKIWI--DYNQYH-VRFMINTDYQM------LDLLPEEEFGPFEGSMYIGGAT---- 1215
            :.||...||.:.|  |.|..| ||....|..|.      |||         :|.:::||..
Zfish   955 KPLNDNHWHNVMISRDPNNLHTVRIDTKTTSQTTLGAKNLDL---------KGDLFVGGVPEQMY 1010

  Fly  1216 FDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCK---PSCVPSPCRNGAQCKEL 1277
            .||.|.:..|.|..||...:.:||.:.|:.:...|.:.:|.:.|:   .||....|.|...|.:.
Zfish  1011 KDLPKLVHAKEGFQGCLASVDLNGRLPDLMTEALVCVGQIERGCEGPSSSCEEDSCANQGVCLQQ 1075

  Fly  1278 WSSFKCVCNNPWAHIGEFC--------------------------ETNINEKALTFIN--RESFL 1314
            |.:|.|.|:.. .:.|..|                          .|.::..||.||.  .::.|
Zfish  1076 WENFTCDCSMT-TYAGPLCADPGSTYVFGRQGGVITYSWPPHDRPSTRVDRLALGFITLMEDATL 1139

  Fly  1315 MRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNR 1379
            :|...|.|....:.:|       ::||  |...:.|:.|||.|                 |..|.
Zfish  1140 VRVDSSAGLGDYLKLH-------IVKG--NVVAVFNVGTYDIN-----------------IEENG 1178

  Fly  1380 EIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDR 1432
            ::|...||  .||..|.....  |:|:...:.::  |:....|::.|.:...|
Zfish  1179 KLVNDGNY--HIVRFTRSGGN--ATLQVDDLPVI--ERFPPGHIDSHRLGTGR 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389	43/141 (30%)
		EGF_CA	433..476	CDD:238011	13/42 (31%)
		Laminin_G_2	514..640	CDD:280389	34/147 (23%)
		Laminin_G_2	698..817	CDD:280389	33/148 (22%)
		EGF_CA	842..878	CDD:238011	11/35 (31%)
		Laminin_G_2	1112..1240	CDD:280389	38/152 (25%)
		EGF_CA	1256..1297	CDD:238011	12/69 (17%)
		Laminin_G_2	1351..1503	CDD:280389	18/82 (22%)
		LamG	1612..1733	CDD:304605
nrxn1b	NP_001277105.1	LamG	30..188	CDD:238058	46/153 (30%)
		EGF	207..237	CDD:278437	11/30 (37%)
		LamG	280..419	CDD:214598	36/152 (24%)
		LamG	476..626	CDD:214598	36/153 (24%)
		EGF	654..>676	CDD:278437	6/27 (22%)
		LamG	715..851	CDD:214598	29/165 (18%)
		Laminin_G_2	907..1035	CDD:280389	38/152 (25%)
		Laminin_G_2	1130..1276	CDD:280389	29/128 (23%)
		Syndecan	1403..>1442	CDD:279386
		4.1m	1423..1441	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910