DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and Cntnap1

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_058062.2 Gene:Cntnap1 / 53321 MGIID:1858201 Length:1385 Species:Mus musculus


Alignment Length:1215 Identity:273/1215 - (22%)
Similarity:465/1215 - (38%) Gaps:240/1215 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   428 ATKHENVNEGCSDMCESRHNLCFVGSRCINHYGGISCDCFGTHYEGEHCDI-------------- 478
            ||...|||    |....||:|         ||          |:...:..|              
Mouse   122 ATFFGNVN----DSAVVRHDL---------HY----------HFTARYIRIVPLAWNPRGKIGLR 163

  Fly   479 -------YTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYI 536
                   ||::|:...|...:|||..  :....|.....:..|:|...|..|.:..|.  :..|:
Mouse   164 LGIYGCPYTSSILYFDGDDAISYRFQ--RGASQSLWDVFAFSFKTEEKDGLLLHTEGS--QGDYV 224

  Fly   537 AASIKNQSVHVEMDFGDNVM------STV----LTDDLTRGYWHNLTILHEQRTVSIILDQQQKV 591
            ...::...:.:.|..|.:.:      :||    :.:||:   ||.:.:....|..:..||.....
Mouse   225 TLELQGAHLLLHMSLGSSPIQPRPGHTTVSLGGVLNDLS---WHYVRVDRYGRDANFTLDGYAHH 286

  Fly   592 LELPATASGN---MLFDPEIYFGG--GPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNP 651
            ..|    :|:   :..:.||:.||  |.   .:|.||..:||.|.::.|.||.|:|.......:.
Mouse   287 FVL----NGDFERLNLENEIFIGGLVGA---ARKNLAYRHNFRGCIENVIYNRINIAEMAVMRHS 344

  Fly   652 KVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAE--------EFNIKFDFRSSRPGAVLA 708
            ::.:.|.:....::      |:.:|.   :...|.|..:        ...:.|.||:.....:|.
Mouse   345 RITFEGNVAFRCLD------PVPHPI---NFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLL 400

  Fly   709 YSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELDYKLGEIRFTVD 773
            :|.:  ..|.|..|:.|:..:::..:.......:..:...::|.. .||         |:.|...
Mouse   401 FSHL--GDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDG-FWH---------EVNFVAQ 453

  Fly   774 YRHTLSQM-----------YGLTFNIGDKLIIGSSLKSAA--------MGLVGCIRDIEINGHLI 819
            ..|.:..:           |.|....|.....|...|.|:        ....||:..::::|.|:
Mouse   454 ENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLV 518

  Fly   820 EPRHVVKTE-RVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHF 880
               ::...| |.:|   ||..|.|...|.|. ||.|||.|:|:...|...|.|:.|||.|..||.
Mouse   519 ---NLTLVEFRKLGYFAEVLFDTCGITDRCS-PNMCEHDGRCYQSWDDFICYCELTGYKGVTCHE 579

  Fly   881 TKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHN-LPSQVDVRSA 944
            ..|:::||...|.| ..|..|.||.||:|...|..|.||.:  ||...|:|.|: |.:.....|:
Mouse   580 PLYKESCEAYRLSG-KYSGNYTIDPDGSGPLKPFVVYCDIR--ENRAWTVVRHDRLWTTRVTGSS 641

  Fly   945 RESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSS---AKNLTVDFL 1006
            .:..|...|:|...|...:..|.:.|.:|.|:|::.||.::| |::|..:..|   .:|....|.
Mouse   642 MDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRL-LNTAGGYPYSFWIGRNEEQHFY 705

  Fly  1007 -GNVKRG--ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEA 1068
             |..:.|  .|.|.::::||||...||||..:.:|.:|:|.......|.:|.:........:.||
Mouse   706 WGGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRSNSEA 770

  Fly  1069 QGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAFSFRTTGEKAILLFQ---PPI 1127
            |  ..|.||.|.........::|.|..: :..|..|..   |::|.|||:....:.|..   |..
Mouse   771 Q--FFLRPLRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFC 832

  Fly  1128 RPHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQ 1192
            |...|...|.|.....:.|.|.:..|.....|.:.....|..|||.:..:.|....|..::....
Mouse   833 RWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPW 897

  Fly  1193 MLDLLPEEEF--GPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSE- 1254
            :|..:|.:.:  ..::..:|:|.|.   ||    :...:||.|.:.:||..|::..  ..:.|| 
Mouse   898 VLRPMPLQTYIWLVYDQPLYVGSAE---LK----RRPFVGCLRAMRLNGVTLNLEG--RANASEG 953

  Fly  1255 IIKDCKPSCVPS--PCRNGAQCKELWSSFKCVC-----NNPWAH--IGEFCET------NINEKA 1304
            ...:|...|...  ||.:|.:|.|.:|.:.|.|     :.|:.:  ||.|.||      |: :.|
Mouse   954 TFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNL-QSA 1017

  Fly  1305 LTFINRE--SFLMR-------NYLSVGATP--VILMHG--------------INGERDVLKGILN 1344
            |....||  ..|.|       .|:....||  |...||              :.|.|..:..:..
Mouse  1018 LRSAAREFSHMLSRPVPGYEPGYVPGYDTPGYVPGYHGPGYRLPEYPRPGRPVPGYRGPVYNVTG 1082

  Fly  1345 QDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDE--IVNLTLLDDTLMASLKS 1407
            :::..:..|....|::||.:....:::.:.|..:..:...|..|..  :..||....|   ..:.
Mouse  1083 EEVSFSFSTNSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPVT---DGQP 1144

  Fly  1408 IQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGG 1472
            ..|.|.|..:...:.|:...::..:.:||:|...:.|.:                     .::|.
Mouse  1145 HSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKA---------------------LYLGR 1188

  Fly  1473 YDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAP 1517
            .....::.|.:......|:.||:.|::.            .|:||
Mouse  1189 VMETGVIDPEIQRYNTPGFSGCLSGVRF------------NNVAP 1221

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389
EGF_CA 433..476 CDD:238011 10/42 (24%)
Laminin_G_2 514..640 CDD:280389 33/140 (24%)
Laminin_G_2 698..817 CDD:280389 22/137 (16%)
EGF_CA 842..878 CDD:238011 16/35 (46%)
Laminin_G_2 1112..1240 CDD:280389 30/132 (23%)
EGF_CA 1256..1297 CDD:238011 14/49 (29%)
Laminin_G_2 1351..1503 CDD:280389 24/153 (16%)
LamG 1612..1733 CDD:304605
Cntnap1NP_058062.2 FA58C 37..168 CDD:238014 13/68 (19%)
LamG 200..332 CDD:214598 32/143 (22%)
LamG 363..514 CDD:238058 26/165 (16%)
EGF 545..574 CDD:333761 14/29 (48%)
FReD 585..>659 CDD:294064 26/76 (34%)
LamG 788..938 CDD:238058 35/157 (22%)
LamG 1084..1219 CDD:214598 24/170 (14%)
4.1m 1305..1323 CDD:128590
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1317..1385
SH3-binding. /evidence=ECO:0000255 1334..1370
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.780

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