Protein Alignment axo and Aplp1

DIOPT Version :9

• Sequence 1: NP_001246631.1
• Gene: axo / 43923
• FlyBaseID: FBgn0262870
• Length: 2179
• Species: Drosophila melanogaster
• Sequence 2: XP_038944236.1
• Gene: Aplp1 / 502317
• RGDID: 69257
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 547
• Identity: 94/547 - (17%)
• Similarity: 143/547 - (26%)
• Gaps: 242/547 - (44%)

  Fly  1759 GVRSAQCNAKFDVSEQPTQEPMVNVSMIPEPWVEEPPARVPYIPRFVYDENKQEDSTQVVFLTLT 1823
            |.||.:|       ..|..| :|....:|..:|.| ...||...||::.|...:
  Rat   122 GTRSGRC-------AHPHHE-VVPFHCLPGEFVSE-ALLVPEGCRFLHQERMDQ----------- 166

  Fly  1824 SVFVIIVICCLLEVYRSHLAYKKRIERETDEDIIWSKEQATKMHESPGVKAGLLGGVTAGSGNGL 1888
                     |                           |.:|:.|:.........|.:..|||..|
  Rat   167 ---------C---------------------------ESSTRRHQEAQEACSSQGLILHGSGMLL 195

  Fly  1889 P-------PYTYKALPQEDKKPGNGAPLVGILKNGSATPSQPGTPTA--LSKNGDIASRIE--EE 1942
            |       ...|...|.                  .|||:..|....  .:::..:..|.|  |:
  Rat   196 PCGSDRFRGVEYVCCPP------------------PATPNPSGMAVGDPSTRSWPLGGRAEGGED 242

  Fly  1943 EEEEDEAP------------AQKAAEKSGENEEPPAKDTTA----------------------SE 1973
            |||.:..|            |::..|:..|...||:..|..                      .|
  Rat   243 EEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGE 307

  Fly  1974 IKESQA-----------------QPPEQLAKDTTDASAAPKASK--------------------- 2000
            |.|.:.                 :...:.|...:.:...|||.:
  Rat   308 ISEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGE 372

  Fly  2001 -----ETEAQAEPSEPSSQLNSAQNGQLAQMEQAARGDEVQVPSLPHPIQPPDA--IFMPNLPQK 2058
                 ||.|....:..:.|..:|..|.||    |.:||            ||.|  :.|......
  Rat   373 RQRLVETHATRVIALINDQRRAALEGFLA----ALQGD------------PPQAERVLMALRRYL 421

  Fly  2059 AQQRQPQEHKSRH----KATDDTEAPKQQQQ--------QQQQQQSF------------------ 2093
            ..:::.|.|..||    .|.|..:|.:.:.|        |::..||.
  Rat   422 RAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVVQERMNQSLGLLDQNPHLAQELRPQIQ 486

  Fly  2094 -----------DVATNANGSS--------------------LPASRVKNPEEPGGKSPLVPMRQH 2127
                       ::..:..|||                    ||...........|:..|.|:.|:
  Rat   487 ELLHAEHLGPSELEASVPGSSSEDKGSLQPPESKDADAPVTLPKGSTDQESSSSGREKLTPLEQY 551

  Fly  2128 HSKVTRPPPPPTLFLENSLLQRQFANP 2154
            ..||....|....| .:|.:||....|
  Rat   552 EQKVNASAPRGFPF-HSSDIQRDELAP 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389
		Laminin_G_2	698..817	CDD:280389
		EGF_CA	842..878	CDD:238011
		Laminin_G_2	1112..1240	CDD:280389
		EGF_CA	1256..1297	CDD:238011
		Laminin_G_2	1351..1503	CDD:280389
		LamG	1612..1733	CDD:304605
Aplp1	XP_038944236.1	A4_EXTRA	46..211	CDD:128326	26/144 (18%)
		APP_E2	289..471	CDD:403970	33/197 (17%)
		JMTM_Notch_APP	569..653	CDD:425406	3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900