DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and Nrx-1

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_001262840.1 Gene:Nrx-1 / 42646 FlyBaseID:FBgn0038975 Length:1847 Species:Drosophila melanogaster


Alignment Length:2025 Identity:395/2025 - (19%)
Similarity:678/2025 - (33%) Gaps:677/2025 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 QMDGDIIQTFQLR-----LCREISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQLKV 313
            |:||.....:..|     |...:..:|:|..|:||::|    ..|....|.:.|.::  :|.|::
  Fly   106 QLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLY----TDDGGTYDFFELKLV--EGALRL 164

  Fly   314 VHVFGKHSTSVTVGESLNRDEWHSVMVRIDVHGARLIARVDNSQEEVYLKGLNHEYNYG-VSTNL 377
            .:..|..:..:|||..|:...||.|.|..:.....||  ||...::...||  .|:.:| .::| 
  Fly   165 RYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLI--VDGVSQQRSTKG--KEFQFGKFASN- 224

  Fly   378 PSVVLVGGL----SSEEKLHGVKYI--TESFVGCIRNVVLSSGKAAS----------DL------ 420
             |.|.|||:    ||:..|..:..:  ...|.|.|||:|.:.....|          |:      
  Fly   225 -SDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVP 288

  Fly   421 -----LPI--APLVATKHENVNEGCSDMCESRHNLCFVGSRCINHYGGISCDCFGTHYEGEHCDI 478
                 ||.  .||...:..|..:.|     .|::.|..|..||:...|..|:|....|:|::|:.
  Fly   289 CDHGELPARERPLRGVRGGNTTDAC-----ERNDPCQHGGICISTDSGPICECRNLEYDGQYCEK 348

  Fly   479 YTA-TIITLRGASYVSYRI-YDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIK 541
            ..| :..|.||..::||.: ....:.:.|:...||..|||...:..|||....:   .|:..:::
  Fly   349 EKAPSEATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGT---DYLNLALR 410

  Fly   542 NQSVHVEMDFGDNVM------STVLTDDLTRGYWHNLTILHEQ-----------RTVSIILDQQQ 589
            :..|.:.|...:...      |.|..||   ..||.:|: |.:           |.|:::.|   
  Fly   411 DGGVSLTMGLANGKQEMHIKPSKVRFDD---HQWHKVTV-HRRIQEISSITSFCRLVTVVDD--- 468

  Fly   590 KVLELPATASG--NMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYN----DISILYELQR 648
             |....:..:|  .||....:|.||........|...|.||||.|:.|.::    :::::...:.
  Fly   469 -VYTDHSHIAGKFTMLSSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKS 532

  Fly   649 GNPKVHYHGVLEAEFVENEVNVIPITYPFATSH-IWWPINHAEEFNIKFDFRSSRPGA--VLAYS 710
            |:..:...|.||.:....:.. .|:|:....|| :..|....::.:|.|.||:..|..  |||..
  Fly   533 GSKLIQVAGNLEYQCPSGDPQ-DPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATG 596

  Fly   711 DVTTSAGNG-FWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT----SWHSVEL-----DYKL 765
            .....|.|. ...|.|.:..:...|  |:.:.   ::.::.:|..    .||.:.|     |.|:
  Fly   597 SKQPRAKNPVLIAIELLNGHIYIHL--DLGSG---ASKVRASRRRVDDGDWHDLILRRNGRDAKV 656

  Fly   766 GEIRFTVDYR----HTLSQMYGLTFNIGDKLIIGSSLKSAA-----------MGLVGCIRDIEIN 815
            .......|:|    .|:.::.|..:..|    :|.:..|.:           .|.|||:||:.::
  Fly   657 SVDGVWNDFRTPGDGTILELDGHMYLGG----VGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLS 717

  Fly   816 GHLIEPRHVVKTERVVGEVAL-DNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCH 879
            |..|:   :....||....:: .:|:........|.|.:||.|....:|..|||..|.|.|..|.
  Fly   718 GKAID---IAAFARVQDSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCG 779

  Fly   880 FTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSA 944
                    .|||.|.|..|....|.: |||               ..|||..|..:         
  Fly   780 --------RELATLAFNGSQHMTIWL-GNG---------------QGTKTQTEELV--------- 811

  Fly   945 RESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGNV 1009
                    ||::...|..|                      |.|.||.  ::|...|.:..:...
  Fly   812 --------IRFKTSRPAGL----------------------LLLTSAE--SNSPDRLEIALVAGR 844

  Fly  1010 KRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITL 1074
            .|.:...|..:..:...||.   :.:|.|::                                  
  Fly   845 VRASVRLSDREKNLLAGQSV---LNDNNWHT---------------------------------- 872

  Fly  1075 GPLECVETNTQKYVVTFTTSQSYIEVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALT 1139
                                             |.||.|.:..:..:...||:|           
  Fly   873 ---------------------------------IRFSRRASNLRLQVDGAPPVR----------- 893

  Fly  1140 GDDQLTFTFTLSTGTTRELVINSHRRLN------GGEWHKIWIDYNQYHVRFMINTDYQMLDLLP 1198
                         |...|.::..|..:.      ||.:|                         .
  Fly   894 -------------GMLSETILGRHSTMEIRSVHLGGLFH-------------------------A 920

  Fly  1199 EEEFGPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKP-- 1261
            |||                 ::..|.....:|..:|||.||:     .|:     :|:|...|  
  Fly   921 EEE-----------------IQMTSTMPNFVGQMQGLVFNGQ-----RYL-----DIVKSLGPEL 958

  Fly  1262 SCVPSPCRNGAQCKELWSSFKCVC---NNPWAHIGEFCETNINEKALTFINRESFLMRNYLSVGA 1323
            |.:||            ::||...   |:|   .|:      ...|.||.::.|:       ||.
  Fly   959 SALPS------------ATFKLTARFVNSP---AGQ------PYHAATFRSKHSY-------VGL 995

  Fly  1324 TPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYG 1388
            .             :||...:..:....:|.:.|.|:::.....|:||.:.: :|..|.:.::.|
  Fly   996 A-------------MLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVEL-VNGHIHYTFDLG 1046

  Fly  1389 DEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNE---HSVSIDR-----GTLLLD---EYAN 1442
            |..|.:                     ..::|:|:|:   |.|||.|     .||.:|   |..:
  Fly  1047 DGPVTM---------------------RDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIIS 1090

  Fly  1443 KPWSNPEKEVLSPHRPPAPPTEYFQFHVGGY--DPANLLRPNVDAPALEGYIGCVRGLKIGAQLI 1505
            ...:|...|:..            ..::||.  |..:.|..::.:.:  |:.||:..|       
  Fly  1091 LTGNNMHLELAG------------ILYIGGVFKDMYSKLPASISSRS--GFEGCLASL------- 1134

  Fly  1506 DLADINERNIAPTQEGVLPN------CQ--IKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGE 1562
               |:.:.:.:.|.:.|:|:      |:  .||....|.|.|.|.:.:  ....|:|:.||:.|.
  Fly  1135 ---DLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQW--NAYACECDMTSYTGP 1194

  Fly  1563 FCSEEKGADFSGESTLQRKFELPGTGRVDYVRLQLAFSSFDLRRANRIMLLMQTEAERSYYLLLA 1627
            .|.:|..|...|.:....::..|...:.|.....:|. .|...|.:.::|.:::          |
  Fly  1195 TCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIAL-GFITTRPDAVLLRVES----------A 1248

  Fly  1628 ITSDGYLQLEEDRDN--------------GQTVGARIDRNFLNSARHSVYYVRNGTQSQLFIDRE 1678
            .|.| |::||....|              |: :|.:::.|    |.|.|.:.|.|..:.|.:|..
  Fly  1249 TTQD-YMELEIVEGNIFMVYNIGSVDLPLGE-IGTKVNDN----AYHVVRFQRKGGNATLQLDDY 1307

  Fly  1679 QV----PLSEFAARVLTTGGDAGSNRVQIGGINSTDSRFAVFKSYSGCLSNIYIQVNGHVMKPLE 1739
            .|    |.|..:. |..|     .:.||:||..|.:.|..:.:.::|.::.:.:           
  Fly  1308 NVQALTPQSHHST-VFNT-----MSNVQVGGKFSRNGRNRIERPFAGVIAGLSV----------- 1355

  Fly  1740 EYMLFTKSGADNITVINPQGVRSAQCNAKFDVSEQPTQEPMVNVSMIPEPWVEEPPARVPYIPRF 1804
                      :.:.:::....|......:.||.                            :...
  Fly  1356 ----------NKLRILDLAVERDPHITIRGDVQ----------------------------LVTG 1382

  Fly  1805 VYDENKQEDSTQVVFLTLTSVFVIIVICCLLEVYRSHLAYKKRIERETD--------EDIIWS-- 1859
            |.|.|..:...|    ||.|.                        |:|.        :|:|:|  
  Fly  1383 VLDRNDLQRMQQ----TLNST------------------------RQTPASGYPGALDDLIFSGA 1419

  Fly  1860 --------KEQATKMHESPGVKAGLLGGVTAGSGNGL--PPYTYKALPQEDKKPGN-----GAPL 1909
                    :::.|...||             |||:.|  |.|..........:.||     |:..
  Fly  1420 GSGCRGDDEDECTPPFES-------------GSGDDLITPVYVPPTKQTTTSQQGNSLSTGGSSS 1471

  Fly  1910 VGILKNGS------------------ATPSQPGTPTA--LSKNGDIA-------SRIEEEEEEED 1947
            .|::.||:                  .|.....|.||  ...|.::.       |.:..|:.:..
  Fly  1472 GGVITNGTERACDDEDCVHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQGS 1536

  Fly  1948 E-----------APAQKAAEKS--GENEEPPAKDTTASEIKESQAQPPEQLAKDTTDASAAPKAS 1999
            .           |..|.::..|  |.....|.:.:|.|.:..|..|.....:..|:.::.:...:
  Fly  1537 SSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSSTTSTTTT 1601

  Fly  2000 KETEAQAEPSEPSSQLNSAQNGQL------AQMEQAARG--DEVQVPSLPHPIQPPDAIFMPNLP 2056
            ..|.....|.|..|.:...:....      ..|..:.|.  |.:|:|...||:.|    ..|.:|
  Fly  1602 TTTTQATPPPEIRSTVTERETTPYDIYIAGGGMGGSGRNDHDRMQLPDEHHPLPP----LPPPIP 1662

  Fly  2057 QKAQQRQPQE 2066
                   ||:
  Fly  1663 -------PQD 1665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 42/142 (30%)
EGF_CA 433..476 CDD:238011 12/42 (29%)
Laminin_G_2 514..640 CDD:280389 35/148 (24%)
Laminin_G_2 698..817 CDD:280389 31/145 (21%)
EGF_CA 842..878 CDD:238011 12/35 (34%)
Laminin_G_2 1112..1240 CDD:280389 19/133 (14%)
EGF_CA 1256..1297 CDD:238011 10/45 (22%)
Laminin_G_2 1351..1503 CDD:280389 33/164 (20%)
LamG 1612..1733 CDD:304605 30/138 (22%)
Nrx-1NP_001262840.1 LamG 110..263 CDD:238058 44/164 (27%)
EGF_CA 311..347 CDD:238011 11/40 (28%)
Laminin_G_2 386..517 CDD:280389 35/141 (25%)
LamG 555..716 CDD:238058 38/169 (22%)
EGF 746..777 CDD:278437 12/30 (40%)
Laminin_G_2 814..945 CDD:280389 36/290 (12%)
LamG 988..1136 CDD:238058 38/213 (18%)
EGF 1164..1195 CDD:278437 10/32 (31%)
Laminin_G_2 1233..1356 CDD:280389 32/165 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7752at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.920

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