DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment axo and Nrx-IV

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_524034.2 Gene:Nrx-IV / 39387 FlyBaseID:FBgn0013997 Length:1284 Species:Drosophila melanogaster


Alignment Length:1566 Identity:310/1566 - (19%)
Similarity:536/1566 - (34%) Gaps:510/1566 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   365 LNHEYNYGVSTNLPSVVLVGGLSSEEKLHGVKYITE-------------SFVGCIRNVVLSSGKA 416
            :.:.||:.::.:|....:|..:::..::|..:::||             |:|.......:..|.:
  Fly    82 VENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNS 146

  Fly   417 ASDLLPI----APLVA-------TK-HENVNEGCSDMCESRHNLCFVGSRCINHYGGISCDCFGT 469
            ..:.:..    .|::|       |: |:.:                  |..:..||         
  Fly   147 DGNSIHYNVFEVPIIAQWVRINPTRWHDRI------------------SMRVELYG--------- 184

  Fly   470 HYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQ 534
                  || |.:..:...|...|.|.:.  ::.:.|:...|...|:|.|.:..:.|:.|  .:..
  Fly   185 ------CD-YISENLYFNGTGLVRYDLR--REPITSTKESIRFRFKTAFANGVMMYSRG--TQGD 238

  Fly   535 YIAASIKNQSVHVEMDFGDNVMSTV----LTDDLTRGYWHNLTILHEQRTVSIILDQ-------Q 588
            |.|..:|:..:.:.:|.|..||:::    |.||   ..||::.|...||.:...:|:       |
  Fly   239 YYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDD---NVWHDVVISRNQRDIIFSVDRVIVRGRIQ 300

  Fly   589 QKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISIL------YELQ 647
            .:...|      |:  :.|:|.||.|.:  ::||....||.|.|:.:|:|..:.:      .||.
  Fly   301 GEFTRL------NL--NRELYLGGVPNV--QEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELG 355

  Fly   648 RGNPKVHYHGVLEAEFVENEVNVI---------PITYPFATSHIWWP-INHAEEFNIKFDFRSSR 702
            .|             ::...||.|         |:|:...:|.:... ..:::..|:.|.||:..
  Fly   356 EG-------------YLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYE 407

  Fly   703 PGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDL-VPDVNNNVTHSTTIKINRATSWHSVELDYKLG 766
            ...|:.:.|..:   .|:.::.|...|:..|| |.|....:..:...:.|.. .|||..:..:..
  Fly   408 ETGVMLHHDFYS---GGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDG-KWHSFVISIEKN 468

  Fly   767 EIRFTVDYR----------HTLSQMYGLTFNIGDKLIIGSSLKSAAMGLVGCIRDIEINGHLIEP 821
            .:...:|.|          .|.:|.|          |.|...|:   |.|||:|.|.::|:...|
  Fly   469 RLILNIDQRPMTTTKSMQVATGAQYY----------IAGGKDKN---GFVGCMRLISVDGNYKLP 520

  Fly   822 RHVVKTERVV--GEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYR 884
            :..||.|.|.  .:|.:|.|..||.| .||.|:|.|.|........|||.||||.|..||.:...
  Fly   521 QDWVKGEEVCCGDDVVVDACQMIDRC-NPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNP 584

  Fly   885 KTCEELALLGFTKSDVYL-IDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARE-S 947
            .:|..|..:...:..|.| :|:||:|...|..|.|:|.| :....|.:.|:......|...:| .
  Fly   585 LSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYS-DGRVITTLSHSQEHTTTVDGFQEPG 648

  Fly   948 DFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL--------ELHSATWFTSSAKNLTVD 1004
            .|..:|.| :.:...::.|::.|..|.|.:.|.|..::|        .....:|:. |..|..:|
  Fly   649 SFEQSIMY-DANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWI-SRHNQPMD 711

  Fly  1005 FLGNVKRGA--CPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDE 1067
            :......|:  |.|.:...|.||.:.||||....:|..|.|..::.:.|.:..:.|.......||
  Fly   712 YWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDE 776

  Fly  1068 AQGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGW---RKGDIAFSFRTTGEKAILLFQPPIRP 1129
            ..||.|||||.|...:....||||..:.:.|.:|.:   ..|||...||||.|.:: :|......
  Fly   777 KMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSV-IFHATGPT 840

  Fly  1130 HYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQML 1194
            .|  ..::|.|.::|.|.:...:|.....|..|: .||...||.:.::.|:...|          
  Fly   841 DY--IKLSLNGGNKLQFQYQAGSGPLGVNVGTSY-HLNDNNWHTVSVERNRKEAR---------- 892

  Fly  1195 DLLPEEEFGPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDC 1259
                                                    |||:|                    
  Fly   893 ----------------------------------------LVVDG-------------------- 897

  Fly  1260 KPSCVPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINEKALTFINRESFLMRNYLSVGAT 1324
                                |.|.....|                                  ..
  Fly   898 --------------------SIKAEVREP----------------------------------PG 908

  Fly  1325 PVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGD 1389
            ||..:|            |..||:|...|                                    
  Fly   909 PVRALH------------LTSDLVIGATT------------------------------------ 925

  Fly  1390 EIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLS 1454
                                                             ||.             
  Fly   926 -------------------------------------------------EYR------------- 928

  Fly  1455 PHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQ 1519
                                              :||:||:|.|.:..:::||.:.::|.:    
  Fly   929 ----------------------------------DGYVGCIRALLLNGKMVDLKEYSKRGL---- 955

  Fly  1520 EGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQRKFEL 1584
            .|:...|..:|::.||.|.|||.|.:...  :|||..::|.|..|::|.|.:....|.::.:|| 
  Fly   956 YGISTGCVGRCESNPCLNNGTCIERYDGY--SCDCRWSAFKGPICADEIGVNLRSSSIIRYEFE- 1017

  Fly  1585 PGTGRVDYVRLQLAFSSFDLRRANRIMLLMQTEAERSY-----------YLLLAITSDGYLQLEE 1638
                           .||....|..|.:...|...:.:           ||.:.|::.|:|:...
  Fly  1018 ---------------GSFRSTIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVF 1067

  Fly  1639 D--RDNGQTVGARIDRNFLNSARHSVYYVR--NGTQSQLFIDREQVPLSEFAARVLTTGGDAGSN 1699
            |  .:..:.:..:  ::|.....|.::::|  .|:...|.:|..:.....|.   :....||..|
  Fly  1068 DFGFERQEIIFPK--KHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFD---IKASADAQFN 1127

  Fly  1700 RVQIGGINSTDSRFAVFKSYSGCLSNIYIQVNGHVMKPLEEYMLFTKSGADNITVINPQGVRSAQ 1764
            .:|...|...:|   :...:.||:|.:...    .:.||:  ::|.::...|:..:..| :....
  Fly  1128 NIQYMYIGKNES---MTDGFVGCVSRVQFD----DIYPLK--LMFQQNPPKNVKSLGTQ-LTEDF 1182

  Fly  1765 CNAKFDVSEQPTQEPMVNVSMIPEPWVEEPPARVPYIPRFVYDENKQEDST------QVVFLTLT 1823
            |..      :|...|.:.:...|.|.|:|...|..|         .:.||.      .::||.|.
  Fly  1183 CGV------EPVTHPPIEIETRPPPLVDEEKLRKAY---------NEVDSVLLACLLVILFLLLI 1232

  Fly  1824 SVFVII 1829
            .:|.:|
  Fly  1233 LMFFLI 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 9/58 (16%)
EGF_CA 433..476 CDD:238011 3/42 (7%)
Laminin_G_2 514..640 CDD:280389 37/136 (27%)
Laminin_G_2 698..817 CDD:280389 29/129 (22%)
EGF_CA 842..878 CDD:238011 17/35 (49%)
Laminin_G_2 1112..1240 CDD:280389 23/127 (18%)
EGF_CA 1256..1297 CDD:238011 3/40 (8%)
Laminin_G_2 1351..1503 CDD:280389 9/151 (6%)
LamG 1612..1733 CDD:304605 23/135 (17%)
Nrx-IVNP_524034.2 FA58C 46..185 CDD:214572 17/135 (13%)
FA58C 57..184 CDD:238014 15/119 (13%)
LamG 192..340 CDD:238058 41/164 (25%)
LamG 376..514 CDD:238058 34/154 (22%)
EGF 546..575 CDD:278437 14/29 (48%)
Laminin_G_2 824..943 CDD:280389 43/390 (11%)
EGF_CA 966..998 CDD:238011 13/33 (39%)
Laminin_G_2 1032..1156 CDD:280389 23/135 (17%)
4.1m 1239..1255 CDD:128590 310/1566 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 97 1.000 Domainoid score I4538
eggNOG 1 0.900 - - E1_KOG3516
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6555
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.770

Return to query results.
Submit another query.