DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment axo and kon

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster


Alignment Length:2522 Identity:464/2522 - (18%)
Similarity:782/2522 - (31%) Gaps:977/2522 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 FAKNNTFIQMDGDIIQTFQLRLCREISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQ 310
            |.:|:::     .::......:...:|.||||....|::.::.  ..|.|.|:       :|...
  Fly   214 FMRNDSY-----SLMMKESYAMGETLSLQFRTMASAGVIFFNG--GYDFILLE-------IEDQH 264

  Fly   311 LKVVHVFGKHSTSV--TVGESLNRDEWHSVMVRIDVHGARLIARVDNSQEEVYLKGLNHEYNYGV 373
            |||  .|.|..:.|  ...|.::..:||.|.:|.:.    .||.:.........:| .|......
  Fly   265 LKV--TFNKAGSLVQFMTNEHISDGKWHRVFLRYNA----AIAELSLDDATSGYRG-THANETKA 322

  Fly   374 STNLPSVVLVGGLSSEEKLH----GVKYITESFVGCIRNVVLSSGKAASDLLPIAPLVATKHENV 434
            |.||...|..||:..|.:..    |::....||.||:|:::::.       ||:           
  Fly   323 SINLEKSVFFGGVQEEMRRRLISKGLRINEISFKGCMRDILVND-------LPL----------- 369

  Fly   435 NEGCSDMCESR--------------HNLCFVGSRCINHYGGIS-----CD---CFGTHYEGEHCD 477
              |.::|..||              :|.|.....|..|  |:.     ||   |....::|.. .
  Fly   370 --GFAEMTISRSLALNCLWKYPCVEYNPCLKSGICSQH--GVDGFICYCDQSYCIKADFQGPF-K 429

  Fly   478 IYTATIITLR------------GASYVSYRIYD--WKDRVHSSTRRISLMFRTNFD---DSALFY 525
            |:|.|...|.            |.:::|....|  ...|.:.|....|::|.....   ...|.|
  Fly   430 IFTETSPELELLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQLLQY 494

  Fly   526 ASGESL---------------KHQYIAASIKNQSVHVEMD---FGD------NVM---------S 557
            ::.:::               |.:|:....:|.:.|..:|   |||      |::         :
  Fly   495 SAEKAIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGKHRFLLHAN 559

  Fly   558 TVLTDDLTRGYWHNLTILHEQRTVSIILDQQQKVLELPATASGNMLF------DPEIYFG----G 612
            ....:|..:...|:..||.....:..:||.....::.|.:..||:::      .|:..||    |
  Fly   560 ITPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCFIVG 624

  Fly   613 GPELHKKKGLASHNNF------VGSLKYVYYNDI--SILYELQ---------------------- 647
            |         |:.:.|      ||.:.|:|.:..  |..||||                      
  Fly   625 G---------ATTSAFSQAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLPVSVHPL 680

  Fly   648 -------RGNPKVH--------------------------------YHGVLEA------------ 661
                   .|...:|                                .||||:.            
  Fly   681 ELRLVNNTGLIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVD 745

  Fly   662 EFVENEVNVIPITYPFATSHIWWPINHAEEFNI----------KFDFR---------SSRPGAVL 707
            .|.::::.:..|.|..::...|     .:||..          .||||         |:||..: 
  Fly   746 WFSDSQLLLGHIRYLHSSDFPW-----QDEFKFIASFGFVTTQTFDFRITFTRLRITSTRPSQI- 804

  Fly   708 AYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELD------YKLG 766
                    :.||..||.||||.||::..|  ..:...|...||.:.|.:..:.::      .||.
  Fly   805 --------SINGSREILLTSDVLSYETTP--IGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLD 859

  Fly   767 EIRFT---VDYRHTLSQMYGLTF-NIGDKL--IIGSSLKSAAMGLVGCIRDIEIN----GHLI-- 819
            .  ||   ::.|....|.:..:: :..|.|  ::..:......|:      :|||    ..||  
  Fly   860 S--FTQQDIEKRRIRYQTHHTSYSSFSDHLEFVVSVAECDDVAGV------LEINYRPPDELINK 916

  Fly   820 ------EPRHVVKTERVVGEVALDNCNY----------------IDPCKRPNTCEHGGKCFVKDD 862
                  ||..|.:     ||.||...|:                :.|       |||..|  |.|
  Fly   917 LGYQNHEPLQVQE-----GERALITKNHFGIRFNIYESLQFQVSLSP-------EHGVIC--KYD 967

  Fly   863 RVTCDCKHTG-----------YIGKN----CH-FTKYRKTCEELALLGFTKSDVYLID------- 904
                  :.||           .:.:|    || .|:..:...||.:|...::|:..:.       
  Fly   968 ------EQTGLTTPVEMFTLEQLFRNDIYYCHDDTESTRDTFELLILSGDETDLQFVSNMEVHIK 1026

  Fly   905 -IDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYREFSP-------- 960
             ::.|..:..| ::..|..:.|..:|:    .|:.:....|..:....:|.|...|.        
  Fly  1027 LVNDNEPYRTA-IERVFHVVRNGIRTL----NPTVLQYLDADVNTNHTDIHYIHVSSTNGAFYKS 1086

  Fly   961 -HML----QELISHSLYCTQYIKYDCYRAQ-------------LELHSATWFTS-SAKNLTVDFL 1006
             |.:    |:.|::.....|:...|...|.             ||:.::..|.| .|.|.::   
  Fly  1087 GHYIDSFTQDDIANRRIMFQHTGADSGTASFIVTDREHEVNGLLEIRASDPFVSMMATNASI--- 1148

  Fly  1007 GNVKRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQ--DPQSLGI---------------- 1053
              |:.|......||..:   ...|.|:|     .||.||:  .|.|.||                
  Fly  1149 --VQEGKFVVLKNKDFI---LETNLDMK-----LDEIYYEVIKPPSYGILMYLSRANEGENGTTI 1203

  Fly  1054 ------TNMYFLQQKDMDDE-------------------------AQGRITL--------GPLEC 1079
                  |::......|::.|                         |:|.:..        .||: 
  Fly  1204 YKATNYTSLSNFTHLDIERERLVYWNTEIASMDKVRYRVHIKNITAEGEVMFRIYPSAYWEPLQ- 1267

  Fly  1080 VETNTQKYVVTFTT---SQSYIEV--PGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALT 1139
            |:.|...||...|:   |:..:||  |....|||.|          |:...|:..:..  |.:::
  Fly  1268 VKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITF----------LVTSSPMHGYLE--MQSMS 1320

  Fly  1140 GDDQLTF-TFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMIN--TDYQMLDLLPEEE 1201
            .||:... .|..|:..|.::                      ::::..:|  |||.:.|:     
  Fly  1321 FDDEYNCKVFDQSSVNTEKM----------------------FYIQAGVNQSTDYFVFDV----- 1358

  Fly  1202 FGPFEGSMYIGGATFDLLKKLSVK-----------AGLIGCFRGLVVNGEILDIYSYMSVHLSEI 1255
                     ..|.|:  |::|.:|           :.:|....|..|.....||..|...:..:|
  Fly  1359 ---------TNGITW--LRQLMIKIVIIPEKLYMHSNIISVVEGKTVQLNPTDIQPYSEYYRGKI 1412

  Fly  1256 IKDCKPSCVPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINEKALTFINRES-------- 1312
            : :...:..|             ||...:..|  :.:..|.:..:.:.::.:::..|        
  Fly  1413 L-EYIVTITP-------------SSGHVLAGN--SKVKRFTQKQLEQGSIQYVHNGSENATDSIT 1461

  Fly  1313 --FLMRNYLSV------------GATPVILMH-GI---NGERDVLKGILNQDLLINLRTYDT--N 1357
              .:.||..||            ...|:::.: |:   ||.|.|:|   |.|||  .:.|||  .
  Fly  1462 LVAMARNKESVPFELEFAVVQVNDEEPMMVTNTGLQVWNGGRYVIK---NTDLL--AQDYDTPPE 1521

  Fly  1358 ALVLYANDHY--------------NNFVHLYISLNREIVFLYNYG-----------DEIVNLTLL 1397
            .|....|..|              .:|....|:| .||.|:::..           |.:.|.|  
  Fly  1522 NLTFVVNHIYGGYLARKSAPHQKIEHFTQAQINL-EEIYFMHDSNSRRNELSFVVTDGLFNTT-- 1583

  Fly  1398 DDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPP 1462
            ...|...:|.|::.....|       |.|...:.:..:|.| |.:...|:.|:|:          
  Fly  1584 TQMLNIEIKPIEILAEHNE-------NLHVFPLTKKQILRD-YLHFKCSDEEREI---------- 1630

  Fly  1463 TEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLID---LADINERNIAPTQEGVLP 1524
                             |.|:..|...|        :|..:.||   ..:::|.    ||..|  
  Fly  1631 -----------------RYNITVPPSLG--------RIVNEFIDNGFTKEVSEF----TQNDV-- 1664

  Fly  1525 NCQIKCDAEPCKNGGTCQEHFA--EQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQRKFELP-- 1585
                       .||....||.|  .:..|.|    ||..:..:|.      .:..|.:||.:.  
  Fly  1665 -----------DNGHIFYEHTAVIMEFRTND----SFYFDVVAER------SDRLLNQKFNIEIS 1708

  Fly  1586 -GTG-----------RVD---YVRLQLAFSSFDLRRANRIMLLMQTEAERSYYLLLAITSDGYLQ 1635
             .:|           .||   .|.::|.||        :|:..::|:|..:       ..:.:::
  Fly  1709 VSSGGLLRFLPVNKLNVDEGGSVPIKLDFS--------KILEYLKTKAGIN-------NPELFIE 1758

  Fly  1636 LEEDRDNGQTVGARIDRNFLNSARH--------SVYYVRNG--------------TQSQLFIDRE 1678
            ..:...:| .:|  :...|.:..|:        .|||:.:.              ||..:|:...
  Fly  1759 AIQKPTHG-NIG--LGHEFKHMQRYHPSDFFTKKVYYIHDHSDTLEDTILMSVYLTQGNIFLCNL 1820

  Fly  1679 QVPLS---------------------EFAARVLTTGG----DAGSNRVQIGGINSTDSRFAVFKS 1718
            .:|:|                     |...|.:|...    ||.:...:|           ::..
  Fly  1821 TIPVSINPINDQPFHLVTHLPQMTVVEGENRTITRNDLLTEDADTPPEEI-----------IYDV 1874

  Fly  1719 YSG-------------------CLSNIYIQ--VNG------HVMKPLEEYMLFTKS-GADN---- 1751
            .||                   ..||.:.|  :|.      |...|......||.| |..|    
  Fly  1875 MSGPTLGVLRKITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMPQSTTFCFTVSDGQSNPAYE 1939

  Fly  1752 -ITV-INPQGVRSAQCNAKFDVSEQPTQEPM--------VNVSMIPEPWVEEPPARVPYIPRF-- 1804
             .|: |:...::.:...|...|.:..|..||        .||.|      |.....|...|.|  
  Fly  1940 IFTIKIDSIHLQPSAMQAPVKVQQGATTAPMRLDHIGVSTNVHM------ERLSYNVTNSPLFGI 1998

  Fly  1805 -VY-----------------------DENKQEDSTQVVFLTLTSVFV-----IIVICCLLEVYRS 1840
             ||                       |.|:..||.||      |.:|     :..:..::||   
  Fly  1999 IVYKHQPTLRFTQQQLETSQISYMQTDLNRSNDSFQV------SAYVPGTNYVAQVDVVMEV--- 2054

  Fly  1841 HLAYKKRIERETDEDIIWSKEQATKMHESPGVKAGLLGGVTAGSGNGLPPYTYKALPQ--EDKKP 1903
                         |.:|...:...|..||.|.|..|:  .:..:.|.|.....|..|:  ..:.|
  Fly  2055 -------------EPVIQINDIVMKEAESSGGKIKLI--TSLDNDNPLSLKLNKFNPKFVITRMP 2104

  Fly  1904 GNGAPLVGILKNGSATPSQPGTPTALSKNGDIAS---------RIEEEEEEEDEAPAQ---KAAE 1956
            ..|.....|...|..|..|....|.:....::.|         .:||.|.:.|....|   |..:
  Fly  2105 STGQIRKIIRSTGLTTDGQSDRSTNIFSYKELRSGVVYFVPHESVEETEADHDSFDYQLLIKTVQ 2169

  Fly  1957 KSGENEEPPAKDTTASEIKESQAQPPE-------------------------------------Q 1984
                    ||:.|.:.|.: |:.:..|                                     :
  Fly  2170 --------PAQATVSIEYR-SRVEETETVHLGSAGLSINYLAIGCAIFIVLICLLIVLLILKIRK 2225

  Fly  1985 LAKDTTDASAAPKASKETEAQAEPSEPSSQLNSAQNGQLAQMEQ---AARGDEVQVP---SLPHP 2043
            |.|...|.|.....:...........|...|:.......|..|.   .|.|:...:|   ::|| 
  Fly  2226 LRKHKADISKDQPPALPCPPDLTSVSPQHHLHHHHGHHYASSEADSVPATGNSTPLPGFSNIPH- 2289

  Fly  2044 IQPPDAIFMPNLPQKAQQRQPQEHKSRHKATDDTEAPKQQQQQQQQ----------QQSFDVATN 2098
                    ...:|.::.:.:..::....:.|||...|:|....|:.          ..|.|:|.:
  Fly  2290 --------CKIIPVESYKHEYPDYDPDEEETDDQCDPQQMMLPQRYNPYHMEHDAWSSSCDMAND 2346

  Fly  2099 ANG-SSLPASRVKNPEEPGGKSPLVPMRQHHSKVTRPPPPPTLFLENSLLQR 2149
            ..| :|:|.|...:...|                  |..|||    |.||:|
  Fly  2347 FAGYASVPQSISGSVSSP------------------PSAPPT----NPLLRR 2376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 36/141 (26%)
EGF_CA 433..476 CDD:238011 13/64 (20%)
Laminin_G_2 514..640 CDD:280389 32/177 (18%)
Laminin_G_2 698..817 CDD:280389 32/143 (22%)
EGF_CA 842..878 CDD:238011 10/50 (20%)
Laminin_G_2 1112..1240 CDD:280389 21/141 (15%)
EGF_CA 1256..1297 CDD:238011 5/40 (13%)
Laminin_G_2 1351..1503 CDD:280389 32/178 (18%)
LamG 1612..1733 CDD:304605 26/194 (13%)
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058 40/171 (23%)
Cadherin_3 507..664 CDD:292802 34/165 (21%)
Cadherin_3 631..776 CDD:292802 22/149 (15%)
Cadherin_3 747..892 CDD:292802 36/162 (22%)
Cadherin_3 861..1005 CDD:292802 33/169 (20%)
Cadherin_3 979..1121 CDD:292802 24/146 (16%)
Cadherin_3 1093..1242 CDD:292802 29/161 (18%)
Cadherin_3 <1264..1361 CDD:292802 28/145 (19%)
Cadherin_3 1330..1464 CDD:292802 26/187 (14%)
Cadherin_3 1436..1578 CDD:292802 29/147 (20%)
Cadherin_3 1789..1932 CDD:292802 25/153 (16%)
Cadherin_3 2009..2163 CDD:292802 34/177 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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