DRSC/TRiP Functional Genomics Resources

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Protein Alignment axo and APLP1

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_001019978.1 Gene:APLP1 / 333 HGNCID:597 Length:651 Species:Homo sapiens


Alignment Length:459 Identity:90/459 - (19%)
Similarity:133/459 - (28%) Gaps:181/459 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1861 EQATKMHESPGVKAGLLGGVTAGSGNGLP-------PYTYKALPQEDKKPGNGAPLVGILKNGSA 1918
            |.:|:.|:.........|.:..|||..||       ...|...|    .||...|      :|:|
Human   168 ESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCP----PPGTPDP------SGTA 222

  Fly  1919 TPSQPGTPTALSKNGDIASRIE--EEEEEEDEAP--------AQKAAEKSGENEEPPAKDTTA-- 1971
            .    |.|:  :::....||:|  |:||||:..|        ....||:..|...||:..|.|  
Human   223 V----GDPS--TRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVV 281

  Fly  1972 --------------------SEIKESQA-----------------QPPEQLAKDTTDASAAPKAS 1999
                                .||.|.:.                 :...:.|.....:...|||.
Human   282 GKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKAD 346

  Fly  2000 K--------------------------ETEAQAEPSEPSSQLNSAQNGQLAQME----QAAR--- 2031
            :                          ||.|....:..:.|..:|..|.||.::    ||.|   
Human   347 RQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411

  Fly  2032 --------GDEVQVPSLPHPIQPPDAIFMPNLPQKAQQRQPQEH--------------------- 2067
                    ..:.|..:|.| .|...|:.    |:||||.:.|.|                     
Human   412 ALRRYLRAEQKEQRHTLRH-YQHVAAVD----PEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471

  Fly  2068 --------------KSRHKATDDTEAP-----KQQQQQQQQQQSFDVATNANGSSLPASRVKNPE 2113
                          .|.|....:.|||     .:.:...|...|.|..|       |.:..|...
Human   472 HLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADT-------PMTLPKGST 529

  Fly  2114 EPGGKSP----LVPMRQHHSKVTRPPPPPTLFLENSLLQRQFANPISYLGGPRLQPRSNRTSIDS 2174
            |....||    :.|:.|:..||            |:.:.|.|....|.:....|.|.....|.::
Human   530 EQDAASPEKEKMNPLEQYERKV------------NASVPRGFPFHSSEIQRDELAPAGTGVSREA 582

  Fly  2175 ILSL 2178
            :..|
Human   583 VSGL 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389
EGF_CA 433..476 CDD:238011
Laminin_G_2 514..640 CDD:280389
Laminin_G_2 698..817 CDD:280389
EGF_CA 842..878 CDD:238011
Laminin_G_2 1112..1240 CDD:280389
EGF_CA 1256..1297 CDD:238011
Laminin_G_2 1351..1503 CDD:280389
LamG 1612..1733 CDD:304605
APLP1NP_001019978.1 A4_EXTRA 46..211 CDD:128326 10/42 (24%)
GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 50..146
APP_N 55..154 CDD:280358
CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 154..212 11/47 (23%)
APP_Cu_bd 156..211 CDD:289676 10/42 (24%)
Copper-binding. /evidence=ECO:0000250 158..178 3/9 (33%)
Zinc-binding 204..211 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..287 22/84 (26%)
APP_E2 285..467 CDD:289677 30/186 (16%)
O-glycosylated at three sites 285..305 1/19 (5%)
Heparin-binding. /evidence=ECO:0000250 310..342 1/31 (3%)
Heparin-binding. /evidence=ECO:0000250 410..441 6/35 (17%)
Collagen-binding. /evidence=ECO:0000250 442..459 5/16 (31%)
APP_amyloid 597..648 CDD:287486
Basolateral sorting signal. /evidence=ECO:0000250 605..616
Interaction with DAB1. /evidence=ECO:0000250 633..650
Interaction with DAB2. /evidence=ECO:0000250 637..651
Clathrin-binding. /evidence=ECO:0000255 641..644
NPXY motif, contains endocytosis signal 641..644
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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