DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and hhip

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001073481.1	Gene:	hhip / 326102	ZFINID:	ZDB-GENE-030131-4827	Length:	693	Species:	Danio rerio

Alignment Length:	838	Identity:	158/838 - (18%)
Similarity:	255/838 - (30%)	Gaps:	329/838 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   875 GKNCHFTKYRKTCEELALLGFTKSDVYLIDIDGNG-------VFPPAHVKC------DFQSLENA 926
            |:....:..|:.|.:.:|....|.....:.::|:|       ::|  .|.|      .:|.|...
Zfish    25 GEKGELSPRRRRCYDGSLPRRLKKKERKLSLEGSGGGEVCHRLYP--RVSCCPSRRAPYQILHRK 87

  Fly   927 -TKTIVEHNLPSQ---VDVRSAR---ESDFSFNIRYREFSPHMLQEL--ISHSLYCTQYIKYDCY 982
             .:|...:|....   .:::.|.   .:...|:....|.:||..|:|  :.|. ||.::. |.|.
Zfish    88 DARTFSTNNTECSRLLEEIKCAHCSPNAQMLFHSPKLEKAPHREQDLPHLCHD-YCQEFY-YTCR 150

  Fly   983 RAQLELHSATWFTSSAKNLTVD----FLGNVKRGAC-PCSVNKTCVDPNQSCNCDVKENKWNSDE 1042
            ....||..|          .||    :.|.:..|.| |                |....:...|.
Zfish   151 GHVPELFQA----------DVDEFCQYYGRMDGGLCFP----------------DFHRKQLRRDS 189

  Fly  1043 GYYQDPQSLGIT-----NMYF-------LQQKDMDDEAQGRITLGPLECVETNTQKYVV------ 1089
            .|..|.::..|.     |.|.       |||           .:|.:.|.:.:.:.:::
Zfish   190 NYLLDEKTEAINRKHKHNCYCAQEIHSGLQQ-----------PVGVVHCGDGSQRLFILEREGFV 243

  Fly  1090 -TFTTSQSYIEVP----------GWRKGDIAFSFRTTGEKAI--LLFQPPIRPHYPSFMVALTGD 1141
             ..|.....::.|          |.:.||         |:.:  |.|.|..:.:...::...|..
Zfish   244 WILTHDMELLKEPFLDIHKLVQSGLKGGD---------ERGLLSLAFHPNYKKNGKLYVSYTTNQ 299

  Fly  1142 DQLTF----------TFTLS--------TGTTREL--VINSHRRLNGGEWHKIWIDYNQYHVRFM 1186
            ::.|.          .:|:|        |.|.|.|  |...||:..||
Zfish   300 ERWTIGPHDHILRVVEYTVSRKNPNQVDTRTPRVLMEVAELHRKHLGG----------------- 347

  Fly  1187 INTDYQMLDLLPEEEFGPFEGSMYI----GGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSY 1247
                 |:|       ||| :|.::|    |..|.|.::::.   ||..      ..|.:|.:
Zfish   348 -----QLL-------FGP-DGLLHIFLGDGMITLDNMEEMD---GLSD------FTGSVLRV--- 387

  Fly  1248 MSVHLSEIIKDCKPSCVPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINEKALTFINRES 1312
                      |....|..:|             :....|||:     |..||
Zfish   388 ----------DVDTECCSTP-------------YSIPRNNPY-----FNSTN------------- 411

  Fly  1313 FLMRNYLSVGATPVILMHGINGER----DVLKGILNQDLLI------NLRTYDTNALVLYANDHY 1367
                      ..|.|..||::...    |.|:...|..|||      ...|.....|.:.....|
Zfish   412 ----------QPPEIFAHGLHDPGRCAVDKLRMDTNGSLLILCTDTVGKNTTTGRILQVIKGKDY 466

  Fly  1368 NN------------------FVHLYISLNREIVFLYNYGDEIVNLTL----LDDTL-------MA 1403
            .|                  |::.... :|.:...|.:||:..|..:    |:|.|       :.
Zfish   467 ENEPSMFDLGSSGGTTPVGGFIYRGCQ-SRRLYGSYVFGDKNGNFRILQRPLEDRLWQEKPLCLG 530

  Fly  1404 SLKSIQVAIVR-----GEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPE-KEVLSPHRPPAPP 1462
            :..|...::|.     ||.|           :....:|:...:....|:.: .:::.|.||..
Zfish   531 TSSSCGSSLVGHILGFGEDE-----------LGEVYILVSSKSTAKQSHGKIYKLVDPKRPQV-- 582

  Fly  1463 TEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPT--------Q 1519
                        |....||..|...|.  ..|.|..|.|            :..||        .
Zfish   583 ------------PKECRRPVEDPEMLS--TACSRECKNG------------HCTPTGKCCCNAGW 621

  Fly  1520 EGVLPNC-QIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSE-EKGADFSGE 1575
            ||  |.| :.||:. .|:|||.|.|.     :.|.|:. .|.|..||: |:|....||
Zfish   622 EG--PFCLRAKCEL-ACRNGGVCVEP-----NKCLCKE-GFSGNQCSKGERGTKGDGE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389
		Laminin_G_2	698..817	CDD:280389
		EGF_CA	842..878	CDD:238011	1/2 (50%)
		Laminin_G_2	1112..1240	CDD:280389	29/153 (19%)
		EGF_CA	1256..1297	CDD:238011	7/40 (18%)
		Laminin_G_2	1351..1503	CDD:280389	32/186 (17%)
		LamG	1612..1733	CDD:304605
hhip	NP_001073481.1	Folate_rec	36..212	CDD:281076	40/205 (20%)
hhip	NP_001073481.1	GSDH	218..>420	CDD:285269	52/314 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900