DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Lama4

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001296376.1	Gene:	Lama4 / 309816	RGDID:	1560062	Length:	1817	Species:	Rattus norvegicus

Alignment Length:	1075	Identity:	202/1075 - (18%)
Similarity:	359/1075 - (33%)	Gaps:	287/1075 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 DPYALY------------VIVEKGQLKVVHVFGKHSTSVTVGESLNRDEWHSV-----MVRIDVH 345
            |.:.||            :.::...|..|:..|.....:.: :|.....|.:.     :.|:..|
  Rat   874 DQFVLYLGSKTAKKEYMGLAIKNDNLVYVYNLGTKDVEILL-DSKPVSSWPAYFSIVKIERVGKH 937

  Fly   346 GA--RLIARVDNSQEEVYLKGLNHEYNYGVS----TNLPSVVLVGGLSSEEKLHGVKYITESFVG 404
            |.  ..:..:.::.||.::|  ..|:....|    |...:|..|||:.:..||.....: .|:.|
  Rat   938 GKVFLTVPSLSSTAEEKFIK--KGEFAGDDSLLDLTPEDTVFYVGGVPANFKLPASLNL-PSYSG 999

  Fly   405 CIRNVVLSSGKAASDLLPIAPLVATKH-ENVNEGCSDMCESRHNLCFVGSRCINHYGGISCDCFG 468
            |:....|::        .:..|...|| .|::...|..| :|..|.|..||..:::
  Rat  1000 CLELATLNN--------DVISLYNFKHIYNMDPAKSVPC-ARDKLAFTQSRAASYF--------- 1046

  Fly   469 THYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKH 533
                             ..|:||...|....:.:....| |..:..||..|:..:......|:
  Rat  1047 -----------------FDGSSYAVVRDITRRGKFGQVT-RFDIEIRTPADNGLVLLMVNGSM-- 1091

  Fly   534 QYIAASIKNQSVHVEMDFGDNVMSTVLTDDLTRGY-----WHNLTIL-HEQRTVSIILDQQ---- 588
             :.:..::|..:||..|||.:.....|.|.|.:..     :|.::|: |..:.:.:::|::
  Rat  1092 -FFSLEMRNGYLHVFYDFGFSNGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKS 1155

  Fly   589 --QKVLELPATASGNMLFDPEIYFGGGP-ELHKKKGLASH----NNFVGSLKYVYY--NDISILY 644
              .:..::|.|         :||.||.| |:.:.:.|.:|    .||.|.:|...:  .|.::|.
  Rat  1156 TDNEKKKIPFT---------DIYIGGAPQEVLQSRTLRAHLPLDINFRGCMKGFQFQKKDFNLLE 1211

  Fly   645 ELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAEEFNIKFDFRSSRPGAVLAY 709
              |:....|.| |..|...:.........::..:|.    .|:..:.|...|:||:.:|..:|.|
  Rat  1212 --QKETLGVGY-GCPEDSLISRRAYFNGQSFIASTQ----KISFFDGFEGGFNFRTLQPNGLLFY 1269

  Fly   710 SDVTTSAGNGFWEIRLTSDKLSFDLV--------PDVNNNVTHSTTIKINRATSWHSVELDYKLG 766
               ..|..:..:.|.|.:..:..|:.        ...::.::|.....:: ||.:..|....:||
  Rat  1270 ---YASGSDDVFSISLDNGTVVMDVKGIKVKSADKQYHDGLSHFVVTTVS-ATRYELVVDKSRLG 1330

  Fly   767 EIRFTVDYRHTLSQMYGLTFNIGDKLIIGSSLKSAAMGLVGCI---------RDIEINGHLIEPR 822
            ....|.. :...:|.....|..|     ||.:........|||         ||:|:...   .|
  Rat  1331 SKNPTKG-KAEPTQTTEKKFYFG-----GSPISPQYANFTGCISNAYFTRLDRDVEVEDF---QR 1386

  Fly   823 HVVKTERVVGEVALDNCNYIDP----------CKRPNTCEHGGKCFVKDDRVTCDCKHTGYIG-- 875
            :..|....:.|..:::    .|          ..:|.|.:.|.|        :.|......||
  Rat  1387 YSEKVHTSLYECPIES----SPLFLLHKKGKNSSKPKTNKQGEK--------SKDAPSWDPIGLK 1439

  Fly   876 ---------KNCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDF---QSLENATK 928
                     .:||.:...:..|.....|.|.:.....:          |::.||   .......|
  Rat  1440 FLERKASRDSHCHLSSSPRAIEHAYQYGGTANSRQEFE----------HIQGDFGEKSQFAIRLK 1494

  Fly   929 TIVEHNLPSQVDVRSARESD------------FSFNIRYREFSPHMLQELISHSLYCTQYIKYDC 981
            |...|.:...|.  ...|:|            |.||:.:::..... ||..|..|:
  Rat  1495 TRSSHGMIFYVS--DQEENDFMTLFLAHGRLVFMFNVGHKKLKIRS-QEKYSDGLW--------- 1547

  Fly   982 YRAQLELHSATWF-TSSAKNLTVD----------------------FLGNVKRGACPCSVNKTCV 1023
                   |...:. ..|:..|.:|                      :||.|..|....:|....|
  Rat  1548 -------HDVIFIREKSSGRLVIDGLRVLEERLPPSDAAWKIKGPIYLGGVAPGRAVKNVQINSV 1605

  Fly  1024 DPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITLGPLECVETNTQKYV 1088
            .....|..:::.|    ........|:..:|..:                .||:|     |..|
  Rat  1606 YSFSGCLGNLQLN----GASIASASQTFSVTPCF----------------EGPME-----TGTY- 1644

  Fly  1089 VTFTTSQSYIEVPG----WRKGDIAFSFRTTGEKAILLFQPPI-----RPHYPSFMVALTGDDQL 1144
              |:|...|:.:..    ..|.:|||..|.......|:....:     ..|..|..|.:..::.:
  Rat  1645 --FSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKSGQVIVKVNNGV 1707

  Fly  1145 TFTFTLSTGTTRELVINSHRRLNGGEWHKIWI--DYN--QYHVRFMINTDYQMLDLLPEEEFGPF 1205
            .   ..||..|.:      :.|..|.||:|.:  |.|  |..|...:|.....|:..|.:...|
  Rat  1708 R---DFSTSVTPK------QNLCDGRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPVDHREP- 1762

  Fly  1206 EGSMYIGGATFDLL-KKLSVKAGLIGCFRGLVVNG 1239
               :::||....|| .:|:......||.|..|::|
  Rat  1763 ---VFVGGVPESLLTPRLTPSKPFTGCIRHFVIDG 1794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389	26/135 (19%)
		EGF_CA	433..476	CDD:238011	8/42 (19%)
		Laminin_G_2	514..640	CDD:280389	31/144 (22%)
		Laminin_G_2	698..817	CDD:280389	27/135 (20%)
		EGF_CA	842..878	CDD:238011	8/56 (14%)
		Laminin_G_2	1112..1240	CDD:280389	31/138 (22%)
		EGF_CA	1256..1297	CDD:238011
		Laminin_G_2	1351..1503	CDD:280389
		LamG	1612..1733	CDD:304605
Lama4	NP_001296376.1	EGF_Lam	81..130	CDD:238012
		EGF_Lam	131..185	CDD:238012
		EGF_Lam	187..238	CDD:238012
		Laminin_I	289..547	CDD:283627
		SPEC	314..523	CDD:295325
		ApoLp-III_like	610..798	CDD:304399
		Laminin_II	727..854	CDD:283628
		LamG	853..1008	CDD:214598	27/137 (20%)
		LamG	1044..1202	CDD:238058	37/196 (19%)
		LamG	1232..1372	CDD:238058	28/153 (18%)
		LamG	1483..1618	CDD:238058	25/153 (16%)
		LamG	1642..1793	CDD:238058	38/166 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910