DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Cntnap4

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001100902.1	Gene:	Cntnap4 / 307865	RGDID:	1306459	Length:	1310	Species:	Rattus norvegicus

Alignment Length:	1169	Identity:	281/1169 - (24%)
Similarity:	472/1169 - (40%)	Gaps:	190/1169 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 YTATIITLRGASYVSYRIYDWKDRVHSSTRR--ISLMFRTNFDDSALFYASGESLKHQYIAASIK 541
            |.:.:|.|.|.|.:.||.    |:...|..|  |||.|:|...|..|.:.:|....|  |...::
  Rat   181 YRSVVIDLDGKSSLLYRF----DQNSLSPIRDIISLKFKTMESDGILLHRAGPGGDH--ITLELR 239

  Fly   542 NQSVHVEMDFGD-NVMSTVLTDDLTRG------YWHNLTILHEQRTVSIILDQQQKVLELPATAS 599
            ...:.:.:..|: .:.|:....:||.|      :||::.|....:.|:..:|:.::  ...|...
  Rat   240 RGKLFLLIHSGEARLTSSSRPINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRR--HFHAQGE 302

  Fly   600 GNML-FDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEF 663
            .|.| .|.||.|||.....|...| .:..|.|.|:.::||.:.::...::.:|::...|  ...|
  Rat   303 FNYLDLDYEISFGGISAPAKSVSL-PYKYFRGCLENLFYNGVDVIGLAKQHSPQIITMG--NTSF 364

  Fly   664 VENEVNVIPITYPFATSHIWWPINHAEE-FNIKFDFRSSRPGAVLAYSDVTTSAGNGFWEIRLTS 727
            ..::...:|:|:....|::..|.:..|| .::.|.||:.....:|.:|::...:|:..  :.|:.
  Rat   365 SCSQPQSMPLTFLSTRSYLVLPASSKEEAISVSFQFRTWNKAGLLLFSELWLMSGSLL--LSLSD 427

  Fly   728 DKLSFDL-VPDVN-NNVTHSTTIKINRATSWHSVELDYKLGEIRFTVDYRHTLSQMY-------- 782
            .:|..:| .|..: :::|....:...:   ||||.|..|...:...||...:.:..:
  Rat   428 GRLKLNLHQPGKSPSDITAGAGLDDGQ---WHSVSLSAKRNHLTVVVDGHISPASPWLGPEQVNS 489

  Fly   783 GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPRHVVKTERVVG---EVALDNCNY 841
            |..|..|   || ..||..||...|..||:|.|.|...:::...|  .:..:|   ::.:|:|..
  Rat   490 GGIFYFGGCPDK-SFGSRCKSPLGGFQGCMRLISIQDKMVDLLAV--QQGSLGNFSDLQIDSCGI 551

  Fly   842 IDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELALLGFTKSDVYLIDID 906
            .|.| .||:|||||:|........|:|.:|||.|..||.:.|.::||.....| ..|..|.||.|
  Rat   552 SDRC-LPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKHRG-NASGFYYIDSD 614

  Fly   907 GNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYREFSPHMLQELISHSL 971
            |:|...|..:.|   ::.....|::.||....:.||:|...:....:.....|...||..|:.:.
  Rat   615 GSGPLRPFLLYC---NMTETAWTVIHHNGSDLMRVRNAHSENVHTGVFEYVASMGQLQASINRAE 676

  Fly   972 YCTQYIKYDCYRAQL----ELHSATWFTSSAKNLTVDFLGNVKR-GACPCSVNKTCVDPNQSCNC 1031
            :|.|.:.|.|.:::|    :....:|:..........:.|::.. ..|.|.:...|:|....|||
  Rat   677 HCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPMPQKCTCGLEGNCIDAQYHCNC 741

  Fly  1032 DVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITLGPLECVETNTQKYVVTFTTSQS 1096
            |...|:|.:|.|:....:.|.:|.:..........||..:  ||||.|..........:|.|..|
  Rat   742 DADRNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYK--LGPLLCRGDRPFWNAASFNTEAS 804

  Fly  1097 YIEVP---GWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQLTFTFTLSTGTTREL 1158
            |:..|   |....|::|.|:||....:.|....|...   ..:.|.....:||:|.:..|.. ||
  Rat   805 YLHFPTFHGELSADVSFYFKTTALSGVFLENLGITDF---IRIELRSPTTVTFSFDVGNGPF-EL 865

  Fly  1159 VINSHRRLNGGEWHKIWIDYNQYHVRFMINT---DYQMLDLLPEEEFGPFEG--------SMYIG 1212
            .::|....|..:||         |||...||   ..|:.:|.|:.:..|.:|        .:::|
  Rat   866 SVHSPTHFNDNQWH---------HVRVERNTKEASLQVDELPPKIQAAPTDGHVLLQLNSQLFVG 921

  Fly  1213 GATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSC--VPSPCRNGAQCK 1275
            |..       :.:.|.:||.|.|.:||..||:....:| ...:...|:..|  ....||:|.:|:
  Rat   922 GTA-------TRQRGFLGCIRSLQLNGMALDLEERATV-TPGVQPGCRGHCGSYGKLCRHGGKCR 978

  Fly  1276 ELWSSFKCVCNNPWAHIGEFCETNINEKALTFINRESFLMRNY-----LSVGATPVILMHGINGE 1335
            |..|.|.|.|::. |:.|.||...|:    .:....|.::.|:     ||..::    .|..:..
  Rat   979 EKPSGFFCDCSSS-AYAGPFCSKEIS----AYFGSGSSVIYNFQENYSLSKNSS----FHAASFH 1034

  Fly  1336 RDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDT 1400
            .|:..|  .:.:..|.||....:|:||.:..|..::.:.|:.|..:...|.     :|.....|.
  Rat  1035 GDMKLG--RETVKFNFRTTRAPSLLLYMSSFYKEYLSVIIAKNGSLQIRYR-----LNKYHEPDV 1092

  Fly  1401 LMASLKSI------QVAIVRGEQETRMHVNEHS---VSIDRGT-------LLLD---EYANKPWS 1446
            :...|||:      .:.|.|.|....:.::|::   ..:..||       |:|.   ||::....
  Rat  1093 ISFDLKSMADGQLHHLKISREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQE 1157

  Fly  1447 N---------------------PEKEVLSPHRPP--------------APP---------TEYFQ 1467
            .                     |.|..|.|.||.              ||.         |..|.
  Rat  1158 TALAAAHGFTGCLSAVQFSHIAPLKAALQPGRPAPVTVTGHVTESSCVAPAGTDATSRERTHSFA 1222

  Fly  1468 FHVGGYDPANLLRPNV--DAPALEGYIG-------CVRGLKIGAQLIDLADINERNIAPTQEGV 1522
            .|.|..|....|...:  |:..:.|.|.       ||..  |..::.....:.:||.|...|.|
  Rat  1223 DHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSA--IAVRIYQQKRLYKRNEAKRSENV 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389	33/133 (25%)
		Laminin_G_2	698..817	CDD:280389	33/131 (25%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:280389	34/138 (25%)
		EGF_CA	1256..1297	CDD:238011	14/42 (33%)
		Laminin_G_2	1351..1503	CDD:280389	44/223 (20%)
		LamG	1612..1733	CDD:304605
Cntnap4	NP_001100902.1	FA58C	56..178	CDD:238014
		FA58C	57..179	CDD:214572
		LamG	210..343	CDD:214598	36/137 (26%)
		Laminin_G_2	400..526	CDD:280389	33/131 (25%)
		EGF	555..586	CDD:278437	15/31 (48%)
		FReD	597..>645	CDD:294064	14/51 (27%)
		LamG	796..940	CDD:238058	41/163 (25%)
		Laminin_G_2	1048..1178	CDD:280389	24/134 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I11858
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780