DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and LOC304725

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001316828.2	Gene:	LOC304725 / 304725	RGDID:	1592077	Length:	1293	Species:	Rattus norvegicus

Alignment Length:	1189	Identity:	267/1189 - (22%)
Similarity:	482/1189 - (40%)	Gaps:	214/1189 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR-ISLMFRTNFDDSALF 524
            |:..:.:|..|:.:..|        ..|.|.:.||   :..:..|:.:. |||.|::...|..||
  Rat   166 GMRVEVYGCSYKSDVAD--------FDGQSSLLYR---FSQKTMSTLKDVISLKFKSMQGDGVLF 219

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGDN-----------VMSTVLTDDLTRGYWHNLTILHEQ 578
            :  ||..:..:|...::|..:.:.::..|.           ::.::|.|.    :||::.:....
  Rat   220 H--GEGQRGDHITLELQNGRLVLYLNLDDKKAWLSSITPSAILGSLLDDQ----HWHSVFLERVG 278

  Fly   579 RTVSIILDQ---------QQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKY 634
            :.|:..:|:         :.:||::          |.|:.|||.| :..|.|.....||.|.::.
  Rat   279 KQVNFTVDRNTQHFWTKGETEVLDI----------DYELSFGGIP-VPSKPGTFVKKNFHGCIEN 332

  Fly   635 VYYNDISILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFA-TSHIWWP-INHAEEFNIKFD 697
            :|||.::|:...:|...:::..|  ...|..:|..::|||:..: :|:::.| ....:..::.|.
  Rat   333 LYYNGVNIIDLAKRRKHQIYSVG--NVTFSCSEPQIVPITFVNSRSSYLFLPGTPQIDGLSVSFQ 395

  Fly   698 FRSSRPGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELD 762
            ||:.....:|..:::  |.|:|...:.|.|..|.. |:..|..:.|.|.|.:......||||.::
  Rat   396 FRTWNEDGLLLSTEL--SEGSGTLLLILESGTLRL-LIKKVTGHGTESLTGRSLNDGRWHSVSIN 457

  Fly   763 YKLGEIRFTVDYRHTLS--------QMY-GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEIN 815
            .:...:..||| ...:|        |:| |.::..|   |.|.:...| :......||:|.|.|:
  Rat   458 VRRNRVTLTVD-NDAVSLAPETSGLQIYSGNSYYFGGCPDNLTVSQCL-NPIKAFQGCMRLIFID 520

  Fly   816 GHLIEPRHVVKTER----VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGK 876
            .   :|:.::..::    ...::.:|.|:..|.| .||.|||||.|........|:|..|||.|.
  Rat   521 N---QPKDLISVQQGSLGNFSDLHIDLCSIKDRC-LPNYCEHGGHCTQTWTSFYCNCSDTGYTGA 581

  Fly   877 NCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDV 941
            .||.:.|.::||.....| .|:..:.:|.||:|...|..|.|:.  .|:.....|:|.:.....|
  Rat   582 TCHNSIYEQSCEIYRHRG-NKAGFFYVDSDGSGPLGPLQVYCNV--TEDKIWMTVQHTITELTQV 643

  Fly   942 R-SARESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL----ELHSATWFTSSAKNL 1001
            : |..|..::..:.|.. |...|:.||..|.:|.|.:.|.|.||.|    :....||:...: |.
  Rat   644 QGSNSEKPYAMTLNYGG-SMEQLEALIDGSEHCEQEVTYRCRRAHLFNTQDEAPFTWWIGRS-NE 706

  Fly  1002 TVDFLGNVKRGACPCSVNKTCVDPNQSCNCDVKEN--KWNSDEGYYQDPQSLGITNMYFLQQKDM 1064
            ...:.|....|.             |.|.|.::|:  :..|:.|:......|.:|.:........
  Rat   707 RHPYWGGYVPGV-------------QQCGCGLEESCQEIASNTGFLSSKDHLPVTQIIITNSNRT 758

  Fly  1065 DDEAQGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPP 1126
            :.||..||  |||.|.........|:|:|..||:....:.   ..||:|.|:||....|.|....
  Rat   759 NSEAAWRI--GPLRCYGDRHFWNAVSFSTEASYLHFSAFHVEFSADISFFFKTTALSGIFLENLG 821

  Fly  1127 IRPHYPSFM-VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTD 1190
            |:    .|: :.::...::.|...:..... ||::.|...||..:||.|..:.|       |...
  Rat   822 IK----GFLRLEMSSPSEVIFAIDVGNSPI-ELLVQSPYPLNDNQWHYIQAERN-------IKET 874

  Fly  1191 YQMLDLLPEEE---------FGPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYS 1246
            ...:|.||:.:         .......::|||.:       |.:.|.:||.|.|.:||:.:|:
  Rat   875 LLQVDNLPKNKREVSDQSNFLLQLSSQLFIGGTS-------SRQKGFLGCIRSLHLNGQKIDL-- 930

  Fly  1247 YMSVHLSEIIKDCKPSCVPS-------PCRNGAQCKELWSSFKCVC-NNPWAHIGEFCETNINE- 1302
               ...::|....:|.| |.       .|.||.:|.|..:.:.|.| |:|:.  |.||:..::.
  Rat   931 ---EERAKITPGVRPGC-PGHCSSYGRNCHNGGKCVEKHNGYSCDCTNSPFE--GPFCQKEMSAL 989

  Fly  1303 ----KALTFINRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYA 1363
                .::|::.:|.:.:....|:.::.:.        :|....  .:.:.::..|....||:||.
  Rat   990 FYSGTSVTYMFQEPYPVAKNTSLSSSAIY--------KDTAPS--KEIVTLSFITAQAPALLLYL 1044

  Fly  1364 NDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSV 1428
            .....:|:.:.:|.|..:...|.......::..:....:|:.:..:|.:.|..||..:.|::...
  Rat  1045 KFSPQSFLAILLSRNGSLQIHYQLSKVESHVFTVGSENLANRRVHEVNMNRNGQELSIQVDQQLF 1109

  Fly  1429 SIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQ----FHVGGYDPANLLRPNVDAPALE 1489
            |.:              .:||.|              ||    ..:|......:|.|.|......
  Rat  1110 SYN--------------FSPEVE--------------FQTVRSLILGKVTETLVLNPEVTQANTL 1146

  Fly  1490 GYIGCVRGLKIGAQLIDLADINERNIAP-TQEGVLPNCQIKCDAEPCKNG-----------GTCQ 1542
            |::||:..::........|.:...:||| |.:|.|.........|...||           |...
  Rat  1147 GFVGCLSSVQYNHIAPLKAALRHASIAPVTVQGTLTESSCGSMVESYANGVTTVYSSSDPFGNTD 1211

  Fly  1543 EHFAEQLSTCDCEHTSFLG 1561
            ||  |.|:......::|:|
  Rat  1212 EH--EPLTNAIQSDSAFIG 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	31/145 (21%)
		Laminin_G_2	698..817	CDD:280389	34/130 (26%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:280389	31/137 (23%)
		EGF_CA	1256..1297	CDD:238011	14/48 (29%)
		Laminin_G_2	1351..1503	CDD:280389	28/155 (18%)
		LamG	1612..1733	CDD:304605
LOC304725	NP_001316828.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I11858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920