DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Cntnap5a

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_038946578.1	Gene:	Cntnap5a / 297832	RGDID:	1559812	Length:	1306	Species:	Rattus norvegicus

Alignment Length:	1139	Identity:	272/1139 - (23%)
Similarity:	481/1139 - (42%)	Gaps:	192/1139 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR-ISLMFRTNFDDSALF 524
            |:..:.:|..|..:..|        ..|.|.:.||   :..:..|:.:. |||.|::...|..||
  Rat   166 GMRVEAYGCSYRSDVAD--------FDGRSTLLYR---FNQKTMSTLKDVISLKFKSMQGDGVLF 219

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGDN-----------VMSTVLTDDLTRGYWHNLTILHEQ 578
            :  ||..:..::...::...:.:.::..|:           :|.::|.|.    :||::.:....
  Rat   220 H--GEGQRGDHVTLELQKGRLALYLNLDDSKARLSSTVPLVIMGSLLDDQ----HWHSVLLERVG 278

  Fly   579 RTVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISIL 643
            :..:..:|...:..:....... :..|.|:.|||.| :..|.|.....||.|.::.:|||.::|:
  Rat   279 KQANFTVDMNTQHFQTKGETDA-LDIDYELSFGGIP-VPSKPGTFVKKNFHGCMENLYYNGVNII 341

  Fly   644 YELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFA-TSHIWWP-INHAEEFNIKFDFRSSRPGAV 706
            ...:|...:::..|  ...|..:|..::|||:..: :|::..| ....:..::.|.||:.....:
  Rat   342 DLAKRRKHQIYSVG--NVTFSCSEPQIVPITFVNSRSSYLMLPGTPQIDGLSVSFQFRTWNEDGL 404

  Fly   707 LAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATS---WHSVELDYKLGEI 768
            |..:::  |.|:|...:.|....|.. |:..|   ..|.|.||.....:   ||||.::.:...:
  Rat   405 LLSTEL--SEGSGTLLLILEGGTLRL-LIKKV---AGHGTEIKTGSGLNDGLWHSVSINARRNRV 463

  Fly   769 RFTVDY-------RHTLSQMY-GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPR 822
            ..|:|.       ..:..|:| |.::..|   |.| ..|...:......||:|.|.|:.   :|:
  Rat   464 TLTLDNDAASPAPETSRKQIYSGKSYYFGGCPDNL-TDSQCLNPIKAFQGCMRLIFIDN---QPK 524

  Fly   823 HVVKTER----VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKY 883
            .::..::    ...::.:|.|:..|.| .||.|||||.|........|:|..|||.|..||.:.|
  Rat   525 DLISVQQGSLGNFSDLHIDLCSIKDRC-LPNYCEHGGHCAQTWTTFYCNCSDTGYTGATCHDSIY 588

  Fly   884 RKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-SARES 947
            .::||.....|.|....| :|.||:|...|..|.|:.  .|:.....|:||......|: |:.|.
  Rat   589 EQSCEVYRHKGHTAGFFY-VDSDGSGPLGPLQVYCNI--TEDKIWMTVQHNNTELTRVQGSSPEK 650

  Fly   948 DFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWFTSSAKNLTVDFLG 1007
            .:|..:.|.. |...|:.||..|.||.|.:||.|.|::| |::.     ||:...:......:.|
  Rat   651 PYSMTLNYGG-SMEQLEALIDGSEYCEQELKYHCRRSRL-LNTLDGTPFTWWIGRSNERHPYWEG 713

  Fly  1008 NVKRGA--CPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQG 1070
            :|. |.  |.|.:.::|:|....||||...::|:::.|.:.....|.:|::........:.||..
  Rat   714 SVP-GVQQCGCGLEESCLDNAYFCNCDADMDEWSNNTGLFSLKDHLPVTHVIITDTNRSNSEAAW 777

  Fly  1071 RITLGPLECVETNTQKY---VVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPPIRP 1129
            ||  |||.|   |..::   .|:|:|..||:..|.:.   ..||:|.|:||....:.|....|:
  Rat   778 RI--GPLRC---NGDRHFWNAVSFSTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIK- 836

  Fly  1130 HYPSFM-VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQM 1193
               .|: :.::...::|||..:..|.. ||::.|...||..:||.|..:.|.......:  |...
  Rat   837 ---DFLRLEMSSPSEVTFTIDVGNGPV-ELLVQSPYPLNDNQWHYIRAERNVKETSLQV--DNLP 895

  Fly  1194 LDLLPEEEFGPFE----GSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSE 1254
            |.|....|...|.    ..:::||.:       |.:.|.:||.|.|.:||:..|:.....: :|.
  Rat   896 LSLREASEEAYFRLHLTSQLFVGGTS-------SRQKGFLGCMRSLHLNGQNTDLIERAKL-MSG 952

  Fly  1255 IIKDCKPSC--VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINE-----KALTFINRES 1312
            :...|...|  ..|.|.||.:|.|..|.:.|.|.|. .:.|.||:..|:.     .::|::.:|.
  Rat   953 VTPGCPGHCSSYSSNCHNGGKCVEKQSGYSCDCTNS-PNEGPFCQKEISALFDPGTSVTYMFQEP 1016

  Fly  1313 FLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISL 1377
            :|:....|:.::|:.        .|..:.  .:.:::|..|.....::||.|.....|:.:.:|.
  Rat  1017 YLVIKNTSLLSSPIY--------TDTARS--KETIMLNFLTAQAPTILLYLNFSSQKFLAILLSS 1071

  Fly  1378 N--REIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEY 1440
            |  .:|.|..:.|:..| .|:..:.| |:.:..||.|.:...|..:.:::...|.:..|.:  |:
  Rat  1072 NGSLQIRFRLSKGESHV-YTMSTENL-ANGRVHQVKISKDGPEISIQMDQQLFSYNFSTKV--EF 1132

  Fly  1441 ANKPWS------NPEKEVLSPHRPPAPPTEYFQFHVGGYDP----ANLLRPNVDAPALEGYIGCV 1495
                |:      ....|.|                  |.||    .|:|          |::||
  Rat  1133 ----WTLKSLVLGKVTETL------------------GLDPEVAKVNIL----------GFLGC- 1164

  Fly  1496 RGLKIGAQLIDLADINERNIAPTQ-----EGVLP 1524
                       |:.:...:|||.:     .||.|
  Rat  1165 -----------LSSVQYNHIAPLKAALRHAGVAP 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	27/136 (20%)
		Laminin_G_2	698..817	CDD:280389	32/132 (24%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:280389	33/132 (25%)
		EGF_CA	1256..1297	CDD:238011	14/42 (33%)
		Laminin_G_2	1351..1503	CDD:280389	32/163 (20%)
		LamG	1612..1733	CDD:304605
Cntnap5a	XP_038946578.1	FA58C	42..173	CDD:238014	1/6 (17%)
		Laminin_G_2	209..338	CDD:396680	27/136 (20%)
		LamG	368..520	CDD:238058	37/158 (23%)
		EGF	551..582	CDD:394967	15/31 (48%)
		LamG	793..937	CDD:238058	41/157 (26%)
		EGF	961..>985	CDD:394967	9/23 (39%)
		Laminin_G_2	1045..1173	CDD:396680	33/175 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I11858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920