DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and CNTNAP2

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_054860.1	Gene:	CNTNAP2 / 26047	HGNCID:	13830	Length:	1331	Species:	Homo sapiens

Alignment Length:	1247	Identity:	299/1247 - (23%)
Similarity:	472/1247 - (37%)	Gaps:	286/1247 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFY 525
            |:..:.:|       |. |.|.:|...|...:.||..:.|.:.....  |:|.|:|:..:..:.:
Human   173 GLRIEVYG-------CS-YWADVINFDGHVVLPYRFRNKKMKTLKDV--IALNFKTSESEGVILH 227

  Fly   526 ASGESLKHQYIAASIKNQSVHVEMDFGDN----------VMSTVLTDDLTRGYWHNLTILHEQRT 580
              ||..:..||...:|...:.:.::.|.|          ||:..|.||   .:||::.|..:.|:
Human   228 --GEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDD---HHWHSVVIERQGRS 287

  Fly   581 VSIILDQQQKVLELPATASGNMLF---DPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISI 642
            :::.||:..:...    .:|...:   |.||.|||.| ...|...:|..||.|.::.:.||.::|
Human   288 INLTLDRSMQHFR----TNGEFDYLDLDYEITFGGIP-FSGKPSSSSRKNFKGCMESINYNGVNI 347

  Fly   643 LYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPF---ATSHIWWP--INHAEEFNIKFDFRSSR 702
            ....:|...:....|.|....||      |.|.|.   |||::..|  :|. :.|::.|.||:..
Human   348 TDLARRKKLEPSNVGNLSFSCVE------PYTVPVFFNATSYLEVPGRLNQ-DLFSVSFQFRTWN 405

  Fly   703 PGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-------SWHSVE 760
            |..:|.:|....:.||  .||.||..|:.      |:.|:|.:...:|:.::       .||
Human   406 PNGLLVFSHFADNLGN--VEIDLTESKVG------VHINITQTKMSQIDISSGSGLNDGQWH--- 459

  Fly   761 LDYKLGEIRFTVDYRHTLSQMYG-----------LTFNIGDKLIIG--------SSLKSAAMGLV 806
                  |:||.......:..:.|           |....|:|...|        ||.........
Human   460 ------EVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQ 518

  Fly   807 GCIRDIEINGHLIEPRHVVKTERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDC 868
            ||::.|:::..|:....|  .:|..|   .|::|.|..||.|. ||.|||||||....|...|.|
Human   519 GCMQLIQVDDQLVNLYEV--AQRKPGSFANVSIDMCAIIDRCV-PNHCEHGGKCSQTWDSFKCTC 580

  Fly   869 KHTGYIGKNCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEH 933
            ..|||.|..||.:.|..:||....||.| |:.|.||.||:|...|..|.|:.  .|:...|||.|
Human   581 DETGYSGATCHNSIYEPSCEAYKHLGQT-SNYYWIDPDGSGPLGPLKVYCNM--TEDKVWTIVSH 642

  Fly   934 NLPSQVDVRSARESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TW 993
            :|..|..|.......:|........|...:..:...:.||.||:.|.|..::| |::.     ||
Human   643 DLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRL-LNTPDGSPYTW 706

  Fly   994 FTSSAKNLTVDFLGNVKRG--ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGY--YQD--PQSLG 1052
            :...| |....:.|....|  .|.|.:.:.|.||...||||....:|..|.|:  |:|  |.|..
Human   707 WVGKA-NEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQV 770

  Fly  1053 ITNMYFLQQKDMDDEAQG---RITLGPLECVETNTQKYVVTFTTSQSYIE---VPGWRKGDIAFS 1111
            :..         |.:.||   ::::|||.|..........:|....||:.   ..|....||:|.
Human   771 VVG---------DTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFY 826

  Fly  1112 FRTTGEKAILL-------FQPPIRPHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGG 1169
            |:|.....:.|       |          ..:.|....:::|:|.:..|.. |:|:.|...||..
Human   827 FKTLTPWGVFLENMGKEDF----------IKLELKSATEVSFSFDVGNGPV-EIVVRSPTPLNDD 880

  Fly  1170 EWHKIWIDYNQYHVRFMINTDYQMLDLLPEE-EFGPFEG--------SMYIGGATFDLLKKLSVK 1225
            :||::..:.|.......:       |.||:: ...|.||        .:::|||        ..:
Human   881 QWHRVTAERNVKQASLQV-------DRLPQQIRKAPTEGHTRLELYSQLFVGGA--------GGQ 930

  Fly  1226 AGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSCVP--SPCRNGAQCKELWSSFKCVCNNP 1288
            .|.:||.|.|.:||..||:.....| .|..|..|...|..  :.|.||.:|.|.:..:.|.|:|.
Human   931 QGFLGCIRSLRMNGVTLDLEERAKV-TSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNT 994

  Fly  1289 WAHIGEFCETNINEKALTFINRESFLMRNYLSVGATPVILMHGINGERDVLKG---ILNQDLLIN 1350
             |:.|.||..::.    .|.....:|..|:.:...........::...|....   :..:::..:
Human   995 -AYDGTFCNKDVG----AFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFS 1054

  Fly  1351 LRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGD--EIVNLTLLDDTLMASLKSIQVAIV 1413
            ..|.....::||.:....:|:.:.:.....:...||.|.  |..|:. :|...||:
Human  1055 FSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNID-VDHRNMAN--------- 1109

  Fly  1414 RGEQETRMHVNEHSVSIDRGT----LLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYD 1474
             |:        .|||:|.|..    |.||.|.:          :|.|.|.:..|.:       ..
Human  1110 -GQ--------PHSVNITRHEKTIFLKLDHYPS----------VSYHLPSSSDTLF-------NS 1148

  Fly  1475 PANLLRPNV-------------DAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQ------- 1519
            |.:|....|             :.|   |:.||            |:.:....|||.:
Human  1149 PKSLFLGKVIETGKIDQEIHKYNTP---GFTGC------------LSRVQFNQIAPLKAALRQTN 1198

  Fly  1520 -------EGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGEST 1577
                   :|.|  .:..|.|.|..        .:...|..|..|...|     :...|||...
Human  1199 ASAHVHIQGEL--VESNCGASPLT--------LSPMSSATDPWHLDHL-----DSASADFPYN-- 1246

  Fly  1578 LQRKFELPGTGR 1589
                   ||.|:
Human  1247 -------PGQGQ 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	2/14 (14%)
		Laminin_G_2	514..640	CDD:280389	35/138 (25%)
		Laminin_G_2	698..817	CDD:280389	31/144 (22%)
		EGF_CA	842..878	CDD:238011	19/35 (54%)
		Laminin_G_2	1112..1240	CDD:280389	31/143 (22%)
		EGF_CA	1256..1297	CDD:238011	14/42 (33%)
		Laminin_G_2	1351..1503	CDD:280389	33/170 (19%)
		LamG	1612..1733	CDD:304605
CNTNAP2	NP_054860.1	FA58C	34..181	CDD:214572	2/14 (14%)
		FA58C	<70..180	CDD:238014	1/6 (17%)
		Laminin_G_2	216..345	CDD:280389	35/138 (25%)
		Laminin_G_2	401..529	CDD:280389	31/144 (22%)
		EGF_CA	555..590	CDD:238011	19/35 (54%)
		COLFI	609..>632	CDD:295304	10/24 (42%)
		LamG	800..943	CDD:238058	37/168 (22%)
		LamG	1050..1185	CDD:214598	34/185 (18%)
		4.1m	1282..1300	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11662
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6555
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.730