DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Cntnap5b

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	XP_006529657.1	Gene:	Cntnap5b / 241175	MGIID:	3664583	Length:	1293	Species:	Mus musculus

Alignment Length:	1189	Identity:	266/1189 - (22%)
Similarity:	486/1189 - (40%)	Gaps:	214/1189 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR-ISLMFRTNFDDSALF 524
            |:..:.:|..|:.:..|        ..|.|.:.||   :..:..|:.:. |||.|::...|..||
Mouse   166 GMRVEVYGCFYKSDVAD--------FDGRSSLLYR---FNQKTMSTLKDVISLKFKSMQGDGVLF 219

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGDN-----------VMSTVLTDDLTRGYWHNLTILHEQ 578
            :  ||..:..:|...::|..:.:.::..|:           ::.::|.|.    :||::.:....
Mouse   220 H--GEGQRGDHITLELQNGRLALYLNLDDSKARLSSITPSAILGSLLDDQ----HWHSVLLERVG 278

  Fly   579 RTVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISIL 643
            :..:..:|:..:.......... :..|.|:.|||.| :..|.|.....||.|.::.:|||.::|:
Mouse   279 KQANFTVDRNTQHFRTNGDTDA-LDIDYELSFGGIP-VPSKPGTFLKKNFQGCIENLYYNGVNII 341

  Fly   644 YELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFA-TSHIWWP-INHAEEFNIKFDFRSSRPGAV 706
            ...:|...:::..|  ...|..:|..::|||:..: :|::..| ....:..::.|.||:.....:
Mouse   342 DLAKRRKHQIYSVG--NVTFSCSEPQIVPITFVNSRSSYLLLPGTPQIDGLSVSFQFRTWNEDGL 404

  Fly   707 LAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELDYKLGEIRFT 771
            |..:::  |.|:|...:.|....|.. |:.:|..:.|.|.|.:......||||.::.:...:..|
Mouse   405 LLSTEL--SEGSGTLLLILEGGTLRL-LIKNVAGHGTESLTGRSLNNGQWHSVNINARRNRVTLT 466

  Fly   772 VD-------YRHTLSQMY-GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPRHVV 825
            :|       ......|:| |.::..|   |.| ..|...:......||:|.|.|:.   :|:.::
Mouse   467 LDNDPASPALETPWLQIYSGYSYYFGGCPDNL-TDSQCLNPIKAFQGCMRLIFIDN---QPKDLI 527

  Fly   826 KTER----VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKT 886
            ..::    ...::.:|.|:..|.| .||.|||||.|........|:|.:|||.|..||.:.|.::
Mouse   528 SVQQGSLGNFSDLHIDLCSIKDRC-FPNYCEHGGHCTQTWTNFYCNCSNTGYTGATCHDSIYEQS 591

  Fly   887 CEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-SARESDFS 950
            ||.....|.|....| :|.||:|...|..|.|:.  .|:.....|:||......:: |..|..:.
Mouse   592 CEVYRHRGNTAGYFY-VDSDGSGPLRPLQVYCNV--TEDKIWMTVQHNNTELTWIQGSNTEKPYV 653

  Fly   951 FNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWFTSSAKNLTVDFLGNVK 1010
            .|:.|.. |...|:.||..|.:|.|.:.|.|.|:.| |::.     .|:|..: |....:.|...
Mouse   654 MNLNYGG-SMEQLEALIDGSEHCEQEVTYYCRRSHL-LNTPDGAPFAWWTGRS-NERHPYWGGYF 715

  Fly  1011 RGACPCSVNKTCVDPNQSCNCDVKEN--KWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRIT 1073
            .|             :|.|.|.::|:  :.::|.|:......|.:|.:........:.||..||
Mouse   716 PG-------------DQKCGCGLEESCLEMSNDTGFLSFKDHLPVTQIIISDTNRSNSEAAWRI- 766

  Fly  1074 LGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPPIRPHYPSFM 1135
             |||.|.........|:|:|..:|:.:|.:.   ..||:|.|:||....:.|....::    :|:
Mouse   767 -GPLRCYGDRHFWNAVSFSTEAAYLHIPTFHAEFSADISFFFKTTALSGVFLENLGVK----NFL 826

  Fly  1136 -VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLLPE 1199
             :.::...::.|...:..| ..||::.|...||..:||.|..:.|       |......:|.||:
Mouse   827 RLEMSSPSEVIFAIDVGNG-PMELLVQSPYPLNDNQWHYIQAERN-------IKETLLHVDNLPK 883

  Fly  1200 -----EEFGPF----EGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEI 1255
                 .|.|.|    ...:::||.:       |.:.|.:||.|.|.:||:.:|:     ...::|
Mouse   884 SMRMASEEGHFLLQLNSQLFVGGTS-------SRQKGFLGCIRSLHLNGQKVDL-----EERAKI 936

  Fly  1256 IKDCKPSCV------PSPCRNGAQCKELWSSFKCVC-NNPWAHIGEFCETNINE-----KALTFI 1308
            ....:|.|.      ...|:||.:|.|....:.|.| |:|:.  |.||:..|:.     .::|::
Mouse   937 TSGVRPGCAGHCNSYGRNCQNGGKCVEKHIGYTCDCTNSPYE--GPFCKKEISALFYSGTSVTYM 999

  Fly  1309 NRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHL 1373
            .:|.:.:....|:.::.:.        :|....  .:.:.::..|.....|:||.|....||:.:
Mouse  1000 FQEPYPVTKNTSLSSSAIY--------KDTAPS--KEAITLSFMTAQAPTLLLYLNFSSQNFLAI 1054

  Fly  1374 YISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLD 1438
            .:|.|..:...|....|..::..:....:|:.:..||.:.|...|..:.:::...|.:
Mouse  1055 LLSRNGSLQIQYRLSKEESHVFTISTENLANRRVHQVKMSRDGPELSIQMDQQLFSYN------- 1112

  Fly  1439 EYANKPWSNPEKEVLSPHRPPAPPTEYFQ----FHVG------GYDP----ANLLRPNVDAPALE 1489
                                 .||...||    ..:|      |.||    ||.|
Mouse  1113 ---------------------FPPEVEFQTVRSLILGKVTETLGLDPEVAKANTL---------- 1146

  Fly  1490 GYIGCVRGLKIGAQLIDLADINERNIAP-TQEGVL--PNCQIKCDAE---------PCKNGGTCQ 1542
            |::||:..::........|.:...:|:| |.:|.|  .:|....|::         |....|...
Mouse  1147 GFVGCLSSVQYNHIAPLKAALRHASISPVTVQGTLTESSCDSMIDSDVTGVTTVYSPSVPFGKTD 1211

  Fly  1543 EHFAEQLSTCDCEHTSFLG 1561
            ||  |.|:......::|:|
Mouse  1212 EH--EPLTNTIQSDSAFIG 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	28/136 (21%)
		Laminin_G_2	698..817	CDD:280389	31/129 (24%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:280389	32/137 (23%)
		EGF_CA	1256..1297	CDD:238011	13/47 (28%)
		Laminin_G_2	1351..1503	CDD:280389	31/165 (19%)
		LamG	1612..1733	CDD:304605
Cntnap5b	XP_006529657.1	FA58C	56..173	CDD:238014	1/6 (17%)
		LamG	205..338	CDD:214598	31/140 (22%)
		Laminin_G_2	396..519	CDD:366983	30/126 (24%)
		EGF	551..582	CDD:333761	15/31 (48%)
		LamG	780..924	CDD:238058	39/162 (24%)
		EGF	948..981	CDD:333761	10/34 (29%)
		Laminin_G_2	1032..1157	CDD:366983	31/162 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12035
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780