DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Cntnap3

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001074598.1	Gene:	Cntnap3 / 238680	MGIID:	3588199	Length:	1287	Species:	Mus musculus

Alignment Length:	1405	Identity:	323/1405 - (22%)
Similarity:	539/1405 - (38%)	Gaps:	272/1405 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 RIN---LDPYALYVIVEKGQLKVVHVFGKHSTSVTVGESLNRDEWHSVMVRIDVHG---ARLIAR 352
            |:|   ||...|.:::....|.:|.....|:....:..||.:..:.|.......||   |||..|
Mouse     3 RVNGAFLDALLLLLLLSVQTLPLVAAGDPHNCDAPLASSLPQLSFSSSSQLSSSHGPGFARLNRR 67

  Fly   353 ---------VDNSQ--------EEVYLKGLNHEYNYGVSTNLPSVVLV---GGLS-----SEEKL 392
                     |.|..        |.:.:..:..:..||.|..:.|.:|:   ||.:     .||.:
Mouse    68 DGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYLLMFSDGGRNWKQYHQEESI 132

  Fly   393 HGVKYITESFVGCIRNVVLSSGKAA--SDLLPIAPLVATKHENVNEGCSDMCESRHNLCFVGSRC 455
            .|....|.:     .:||..|.:.:  :..|...||.......:
Mouse   133 SGFPGNTNA-----DSVVQYSLQPSFHTRFLRFLPLTWNPKGRI--------------------- 171

  Fly   456 INHYGGISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDD 520
                 |:..:.:|..|:.|        ::...|.|.:.|: :| ...:......|||.|:...:.
Mouse   172 -----GMRIEVYGCSYKSE--------VVYFDGQSSLLYK-FD-NGAIRPVREVISLKFKAMQNS 221

  Fly   521 SALFYASGESLKHQYIAASIKNQSVHVEMDFGD-------NVMSTVLTDDLTRGYWHNLTI-LHE 577
            ..:|:..|:...|  |...:....:.|.::.||       ::|:..|...|...:||::.| ||.
Mouse   222 GIIFHGKGQHGTH--IVLELNKGKLVVYLNSGDGNLPPVNSIMNFTLGSLLDDRHWHSVLIELHN 284

  Fly   578 QRTVSIILDQQQKVLEL-PATASGNMLFDPEIYFG-----GGPELHKKKGLASHNNFVGSLKYVY 636
            .. ::..||:....:.: ..|:..::.|  ||.||     ||..|     ...|.||.|.|:.:|
Mouse   285 MH-MNFTLDKYMHHVHVNKETSYLDLNF--EISFGEILMPGGRFL-----TFPHKNFHGCLENIY 341

  Fly   637 YNDISILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAEE-FNIKFDFRS 700
            ||.::|:...::...::...|  ...|...:...||:|:..:.|::..|.:..|: .::.|..|:
Mouse   342 YNGVNIIKLAKKHESQILIKG--NVSFTCPQPQTIPVTFLSSGSYLALPSSLREDKMSLAFQLRT 404

  Fly   701 SRPGAVLAYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELDYKL 765
            ......:.:|.|  ..|:|...:.|.:.||..:| .:....:...||..:.....||||.:..|.
Mouse   405 WNKAGHVFFSQV--GHGSGSLVLFLKNGKLILNL-SEPGQPLQSITTGAVLNDGLWHSVSVSAKG 466

  Fly   766 GEIRFTVDYRHTLSQMYGLTFNIGDKLIIGSSLKSAAM--------GLVGCIRDIEINGHLIEPR 822
            ..:...|| ..|...:..:..::||....|....:::.        |..||:|.|.:...:::|
Mouse   467 SYLSLLVD-GDTAQTLMSVEIHLGDTYYFGGCPNNSSSFGCEHSFGGFQGCLRLISVGDKVVDP- 529

  Fly   823 HVVKTERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYR 884
             :...:.|:|   ::.:|:|..||.| .|:.||||.:|....|..:|||:.|||.|..||.:.|.
Mouse   530 -IAVQQGVLGSFSDLQIDSCGIIDRC-LPSYCEHGSRCTQSWDTFSCDCEGTGYTGTTCHSSIYE 592

  Fly   885 KTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARE--- 946
            ::||.....| :.|.:|.||:||:|...|..|.|:..:  :...|:|:|..|..|.||...|
Mouse   593 QSCEAHRHRG-SPSGLYYIDVDGSGPLAPFLVYCNMTA--DTAWTVVQHGGPDVVTVRGGPEGHM 654

  Fly   947 --SDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRA----QLELHSATWFTSSAKNLTVDF 1005
              :.||:.....:     |..:::.:.:|.|.:...|..:    ..:..|.:|:...: |.|..:
Mouse   655 HSATFSYAANAAQ-----LHAVVNVAEHCEQQVDLQCRTSGPSDTGDGTSLSWWVGRS-NETYTY 713

  Fly  1006 LG----NVKRGACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDD 1066
            .|    |.::  |.|.....|:|....||||...|:|.||.......:.|.:|.|..........
Mouse   714 WGGSLPNPQK--CTCGFEGNCIDSQYHCNCDADRNEWTSDTIVLSHKEHLPVTEMVVTDTGRPYS 776

  Fly  1067 EAQGRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPPIR 1128
            ||  ..|||||.|....:.....:|.|..||:..|.:|   ..|:.|.|:||....:.:....|.
Mouse   777 EA--AYTLGPLLCQGDKSFWNSASFNTEASYLHFPTFRGELTADVHFLFKTTISSGVFMENLGIT 839

  Fly  1129 PHYPSFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQM 1193
            ..   ..:.|....::||:|.:..|.. ||.|.|....|...||         |||...|.....
Mouse   840 DF---IRIELRAPTEVTFSFDVGNGPC-ELTIQSPTPFNDNRWH---------HVRAERNVKGAS 891

  Fly  1194 L--DLLPEE-EFGPFEG--------SMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSY 1247
            |  |.||:: :..|.:|        .::|||..       |.:.|.:||.|.|.|||..||: ..
Mouse   892 LQVDQLPQKTQSTPADGHVRLQLNSQLFIGGTA-------SRQKGFLGCIRSLQVNGMALDL-EE 948

  Fly  1248 MSVHLSEIIKDCKPSC--VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINE-----KAL 1305
            .:|....:...|...|  ....||||..|:|......|.|... |:.|..|...|:.     .::
Mouse   949 RAVMTPGVEPGCSGHCSSYGHLCRNGGMCQEKHRGIACDCAFS-AYDGPLCSYEISAYFETGSSV 1012

  Fly  1306 TFINRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNF 1370
            |:..:|      |.::.|....|...::|  ||:  :..:.:.::.||..|..|:||....|..:
Mouse  1013 TYNFQE------YSTLSANTSYLASSLHG--DVI--LSRETITLSFRTTQTPCLLLYVTSFYEEY 1067

  Fly  1371 VHLYISLNREIVFLYNYGDEIVNLTLLD-----DTLMASLKSI------QVAIVRGEQETRMHVN 1424
            :.:.::.|..:...|.          ||     |.....|:::      |:.|.|.|....:.||
Mouse  1068 LSIILANNGSLQVRYK----------LDRHRNADAFNFDLRNLADGHFHQLTINREEAVVSVEVN 1122

  Fly  1425 E---HSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAP 1486
            :   ..|.:..||    |: |...|....:||.|....                     |.....
Mouse  1123 QSTKRQVILSSGT----EF-NAVKSLVLGKVLEPLDAD---------------------PETQQA 1161

  Fly  1487 ALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPNCQIKCDAEPCKNGGTCQEHFAEQLST 1551
            |.:|:.||:..::.|.::...|.:|:.....|.:|.:      ..|..|..|....|.......:
Mouse  1162 AAQGFTGCLSSVRFGLEVPLKAALNQNRARVTIQGSV------AAAAHCAEGPGSAERKLSPGPS 1220

  Fly  1552 CDCEHTSFLGEFCSEEKGADFSGESTLQRKFELPGTGRVD 1591
            .|..|                ||.:  :.:..||.|.|.|
Mouse  1221 MDAGH----------------SGSA--EDRQPLPNTDRSD 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389	32/147 (22%)
		EGF_CA	433..476	CDD:238011	4/42 (10%)
		Laminin_G_2	514..640	CDD:280389	35/139 (25%)
		Laminin_G_2	698..817	CDD:280389	27/126 (21%)
		EGF_CA	842..878	CDD:238011	17/35 (49%)
		Laminin_G_2	1112..1240	CDD:280389	37/138 (27%)
		EGF_CA	1256..1297	CDD:238011	12/42 (29%)
		Laminin_G_2	1351..1503	CDD:280389	34/165 (21%)
		LamG	1612..1733	CDD:304605
Cntnap3	NP_001074598.1	FA58C	57..179	CDD:238014	27/152 (18%)
		FA58C	58..180	CDD:214572	26/152 (17%)
		LamG	186..343	CDD:238058	40/168 (24%)
		Laminin_G_2	402..525	CDD:280389	27/126 (21%)
		EGF_CA	551..586	CDD:238011	17/35 (49%)
		FReD	593..>638	CDD:294064	15/47 (32%)
		LamG	796..940	CDD:238058	43/163 (26%)
		Laminin_G_2	1048..1176	CDD:280389	33/163 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12035
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780