Protein Alignment axo and Nrxn3

DIOPT Version :10

• Sequence 1: NP_001246631.1
• Gene: axo / 43923
• FlyBaseID: FBgn0262870
• Length: 2179
• Species: Drosophila melanogaster
• Sequence 2: XP_036013122.1
• Gene: Nrxn3 / 18191
• MGIID: 1096389
• Length: 1584
• Species: Mus musculus
• Alignment Length: 1902
• Identity: 389/1902 - (20%)
• Similarity: 649/1902 - (34%)
• Gaps: 639/1902 - (33%)

  Fly   270 EISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQLKVVHVFGKHSTSVTV--GESLNR 332
            ::||||:|.:..|||:|.:    |....|...|.::..:.||:    |.......||  .:.:|.
Mouse    50 DLSFQFKTNVSTGLLLYLD----DGGVCDFLCLSLVDGRVQLR----FSMDCAETTVLSNKQVND 106

  Fly   333 DEWHSVMVRIDVHGARLIARVDNSQEEV-----YLKGLNHEYNYGVSTNL-PSVVLVGGLSSEEK 391
            ..||.:||..|.....|:...:....|:     |:..::..:..||..:: ||.:.:.|:.|...
Mouse   107 SSWHFLMVSRDRVRTGLVIDGEGQSGELRPQRPYMDVVSDLFLGGVPADIRPSALTLDGVQSMPG 171

  Fly   392 LHGVKYITESFVGCIRNVVLSSGKAASDLLPIAPLVATKHENVNEGCSDMCESRHNLCFVGSRCI 456
            ..|:.            :.|..|.:...||        ..::|.......|..|.  |..|..|.
Mouse   172 FKGLM------------LDLKYGNSEPRLL--------GSQSVQLEAEGPCGERP--CENGGICF 214

  Fly   457 NHYGGISCDCFGTHYEGEHC--DIYTA-------------------TIITLRGASYVSYRIYDWK 500
            ...|..:|||..|.|.|..|  |:...                   .:.|.||:.|:.|.:.  :
Mouse   215 LLDGHPTCDCSTTGYGGTLCSEDVSQGPGLSHLMMSEQGRSKAREENVATFRGSEYLCYDLS--Q 277

  Fly   501 DRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV---LTD 562
            :.:.||:..|:|.|:| :..:.|...:|:|.  .|:..::|:.:|.:.::.|......:   :..
Mouse   278 NPIQSSSDEITLSFKT-WQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAFEAIVEPVNG 339

  Fly   563 DLTRGYWHNLTILHEQRTVSIILDQQQKVLELPATASG------NML-FDPEIYFGGGPELHKKK 620
            ......||::.:....|.|:|.:|   .:|    |.:|      .|| .|...|.||.|......
Mouse   340 KFNDNAWHDVKVTRNLRQVTISVD---GIL----TTTGYTQEDYTMLGSDDFFYVGGSPSTADLP 397

  Fly   621 GLASHNNFVGSLKYVYYNDISILYELQR----GNPKVHYHGVLEAEF-VENEVNVIPITYPFATS 680
            |....|||:|.||.|.|.:..|..||.|    |:.|:..:|  |..| .||...:.||.:....:
Mouse   398 GSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYG--EVVFKCENVATLDPINFETPEA 460

  Fly   681 HIWWP-INHAEEFNIKFDFRSSRPGAVLAYS--------DVTTSAGN--GFWEIRLTSDKLSFDL 734
            :|..| .|.....:|.||||::.|..::.::        ||.:....  .|:.:.|....|.  |
Mouse   461 YISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDVRSQKNTKVDFFAVELLDGNLY--L 523

  Fly   735 VPDVNNNVTHSTTIKINRAT-------SWHSVEL--DYKLGEIRFTVDYRHT------------- 777
            :.|:.     |.|||: :||       .|:.|::  |.:.|.|  :|:.|.|
Mouse   524 LLDMG-----SGTIKV-KATQKKANDGEWYHVDIQRDGRSGTI--SVNSRRTPFTASGESEILDL 580

  Fly   778 LSQMY--GLTFNIGDKLIIGSSLKSAAM--GLVGCIRDIEINGHLIEPRHVVKTERVVG------ 832
            ...||  ||..|... ||:.:.|.:|.:  |.||||||:.|:|.....|.:.:.:...|
Mouse   581 EGDMYLGGLPENRAG-LILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCS 644

  Fly   833 EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELALLGFTK 897
            .::...|:.. |||....|:.|...|:      |||..|||.|:.|.        .|.::|.:..
Mouse   645 RMSAKQCDSY-PCKNNAVCKDGWNRFI------CDCTGTGYWGRTCE--------REASILSYDG 694

  Fly   898 SDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYREFSPHM 962
            | :|:                         |.|:...:.::.:       |.||
Mouse   695 S-MYM-------------------------KVIMPMVMHTEAE-------DVSF----------- 715

  Fly   963 LQELISHSLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGNVKRGACPCSVNKTCVDPNQ 1027
              ..:|...|              .|..||....||..|.::..|    |.....||..|:..|
Mouse   716 --RFMSQRAY--------------GLLVATTSRDSADTLRLELDG----GRVKLMVNLDCIRIN- 759

  Fly  1028 SCNCD-----------VKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRIT-------- 1073
             ||..           :.:|:|::.. ..:..:||.:|       .| ||.|:|.:.
Mouse   760 -CNSSKGPETLYAGQKLNDNEWHTVR-VVRRGKSLKLT-------VD-DDVAEGTMVGDHTRLEF 814

  Fly  1074 ---------------------LGPLECVETNTQKYV--------------------------VTF 1091
                                 :|.|:.:..|...|:                          |||
Mouse   815 HNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTF 879

  Fly  1092 TTSQSYI---EVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQ---------- 1143
            .|..||:   .:..:....:.|.|:||.....:||.              :||..
Mouse   880 KTKSSYLTLATLQAYTSMHLFFQFKTTSADGFILFN--------------SGDGNDFIAVELVKG 930

  Fly  1144 -LTFTFTLSTGTTRELVI--NSHRRLNGGEWHKIWI--DYNQYH--------VRFMINTDYQMLD 1195
             :.:.|.|..|..   ||  ||.|.||..:||.:.|  |.:..|        |..:|| ..:.||
Mouse   931 YIHYVFDLGNGPN---VIKGNSDRPLNDNQWHNVVITRDSSNTHSLKVDTKVVTQVIN-GAKNLD 991

  Fly  1196 LLPEEEFGPFEGSMYIGGAT----FDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEII 1256
            |         :|.:|:.|..    .:|.|.::.:.|..||...:.:||.:.|:.:.......:|.
Mouse   992 L---------KGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIE 1047

  Fly  1257 KDCK----------PS--CVPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINEKALTFI- 1308
            :.|:          ||  |....|.|...|.:.|..|.|.|:.. ::.|..|    |:...|:|
Mouse  1048 RGCEVALTKADLQGPSTTCQEDSCANQGVCMQQWEGFTCDCSMT-SYSGNQC----NDPGATYIF 1107

  Fly  1309 -------------NRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALV 1360
                         |.......:.|:||.:..: ..||....|...|:
Mouse  1108 GKSGGLILYTWPANDRPSTRSDRLAVGFSTTV-KDGILVRIDSAPGL------------------ 1153

  Fly  1361 LYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMHVNE 1425
                   .:|:.|:|...: |..::|.|                  ::.::|    :|.|..||:
Mouse  1154 -------GDFLQLHIEQGK-IGVVFNIG------------------TVDISI----KEERTPVND 1188

  Fly  1426 ---HSVSIDR----GTLLLDEY---ANKPWSNPEKEVLS------PHRPPAPPTEYF-------- 1466
               |.|...|    .||.:|.:   .:.|..|.:.|.|.      |.:...|..|:.
Mouse  1189 GKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERLQMVKQKIPFKYNRPVEEWLQEKGRQLT 1253

  Fly  1467 ------QFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKI-GAQLIDLADINERNIAPTQEGVLP 1524
                  |..:||.|...|.:            |.:.||.. |.:::::|..|..||.       .
Mouse  1254 IFNTQAQIAIGGKDKGRLFQ------------GQLSGLYYDGLKVLNMAAENNPNIK-------I 1299

  Fly  1525 NCQIKCDAE-PCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQRKFELPGTG 1588
            |..::...| |..:|.|.......::||...|.|:.:.              :|..||
Mouse  1300 NGSVRLVGEVPSVSGTTQTTSMPPEMSTTVMETTTTMA--------------TTTTRK------- 1343

  Fly  1589 RVDYVRLQLAFSSFDLRRANRIMLLMQTEAERSYYLLLAITSDGYLQLEEDRDNGQTVGARIDRN 1653
                               ||....:|.            |||                     :
Mouse  1344 -------------------NRSTASIQP------------TSD---------------------D 1356

  Fly  1654 FLNSARHSVYYVRNGTQSQLFIDREQVPLSEFAARVLTT----GG-----------DAGSNRVQI 1703
            .::||..|       :..:.|::.|  |.::   :.|:|    ||           |...|:|..
Mouse  1357 LVSSAECS-------SDDEDFVECE--PSTD---KSLSTSIFEGGYKAHAPKWESKDFRPNKVSE 1409

  Fly  1704 GGINSTDS------RFAVFKSYSGCLSNIYI-QVNGHVMKPLEEYMLFTKSGADNITVINPQGVR 1761
            ....:|.|      ||.. .|.||.:..:.. ::|...:||..:.:|.....|
Mouse  1410 TSRTTTTSLSPELIRFTA-SSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTA------------ 1461

  Fly  1762 SAQCNAKFDVSEQPTQEPMVNVSM---IPEPWVEEPP-ARVPYIPRFVYDENKQEDSTQVVFLTL 1822
                   :::.....:.|::...|   :|.....||. .|||.....:    ::..||..:.:.:
Mouse  1462 -------YELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVI----RESSSTTGMVVGI 1515

  Fly  1823 TSVFVIIVICCLLEVYRSHLAYKKRIE--RETDEDIIWSKEQATKMHESPGVKAGLLGGVTAGSG 1885
            .:...:.::..|..:|:    |:.|.|  .:.||    ::...:...:|.|.   |:....|.|.
Mouse  1516 VAAAALCILILLYAMYK----YRNRDEGSYQVDE----TRNYISNSAQSNGT---LMKEKQASSK 1569

  Fly  1886 NGLPPYTYKALPQEDKK 1902
            :|     :|....:||:
Mouse  1570 SG-----HKKQKNKDKE 1581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	Kunitz-type	119..170	CDD:438633
		Laminin_G_2	275..413	CDD:460494	31/145 (21%)
		EGF_CA	433..476	CDD:238011	13/42 (31%)
		Laminin_G_2	514..640	CDD:460494	34/135 (25%)
		Laminin_G_2	698..817	CDD:460494	41/154 (27%)
		EGF_CA	842..878	CDD:238011	13/35 (37%)
		Laminin_G_2	1112..1240	CDD:460494	37/154 (24%)
		EGF_CA	1256..1297	CDD:238011	12/52 (23%)
		Laminin_G_2	1351..1503	CDD:460494	33/182 (18%)
		Laminin_G_2	1612..1733	CDD:460494	25/142 (18%)
		PHA03247	<1895..2164	CDD:223021	2/8 (25%)
Nrxn3	XP_036013122.1	LamG	27..181	CDD:238058	34/150 (23%)
		EGF	202..231	CDD:394967	11/30 (37%)
		LamG	286..417	CDD:214598	36/140 (26%)
		LamG	474..623	CDD:214598	44/159 (28%)
		EGF_CA	651..684	CDD:238011	14/39 (36%)
		LamG	712..846	CDD:214598	31/175 (18%)
		Laminin_G_2	903..1031	CDD:460494	37/154 (24%)
		LamG	1104..1283	CDD:238058	42/239 (18%)
		Syndecan	1510..1562	CDD:460035	10/62 (16%)
		4.1m	1530..1548	CDD:128590	6/25 (24%)