DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and mlt-11

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001256938.1	Gene:	mlt-11 / 180352	WormBaseID:	WBGene00012186	Length:	3129	Species:	Caenorhabditis elegans

Alignment Length:	1604	Identity:	294/1604 - (18%)
Similarity:	481/1604 - (29%)	Gaps:	536/1604 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 IEPRHVVKTERVVGEVALDNCNYIDPCKRPNTCEHGG--KCFVKDDRVTCDCKHTGYIGKNCHFT 881
            |:....|.|:..|| |:|           |..| ||.  :.|..:|...|:.......|.|.:..
Worm   412 IQSSRTVNTKECVG-VSL-----------PGPC-HGSFQRYFYNEDSQKCEQFTYSGCGGNGNNY 463

  Fly   882 KYRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHV-KCDFQSLENATKTIVEHNLPSQVDVRSAR 945
            :.|:.||:..                  ..||..: ||:           :...|.:::.|
Worm   464 ESREACEDRC------------------APPPVGLPKCE-----------IGEPLKTKIGV---- 495

  Fly   946 ESDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDC---YRAQLELHSATWFTSSAKNLTVDFLG 1007
                                    .:.|.   |.||   ||..:..||:.....:.|.:.:...|
Worm   496 ------------------------PVNCA---KTDCPSGYRCSVVQHSSVCCPENNKVVGLQTSG 533

  Fly  1008 NVKRGACPCSVNKTCVDPNQSC---------NCDVKENK---WNSDEGYYQD------------P 1048
               ..|..||:.|    ....|         |.|:.|.|   |...||...:            .
Worm   534 ---ARATRCSLPK----ERGPCDKYELRFYFNADLNECKYFFWGGCEGNQNNFERVEDCESACGV 591

  Fly  1049 QSLGITNMYFLQQKDMDDEAQG-RITL--GPLECVETNTQKYVVTFTTSQSYIEVPGWRKGDIAF 1110
            |..|:||....:.:    ..|| |||.  |.|...||...:.....||:......|
Worm   592 QKSGVTNRPNTEIR----TTQGIRITPNGGKLSWEETEEDEEHAVPTTTPLAPSAP--------- 643

  Fly  1111 SFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQLTFT----FTLSTGTTRELVINSHRRLNGGEW 1171
            :.|.:.::|.:...|  ||..|:.....|...:|..|    .|:......|..:....:.:|.|.
Worm   644 TVRVSTQRAPVPTTP--RPTAPAVQTTTTRASRLETTRVPVKTVEDEEEEEEEVVEEEQEDGKEE 706

  Fly  1172 HKIWIDYNQYHVRFMINTDYQMLDLLPEEEFGPFEGSMYIGG---ATFDLLKKLSVKAGLIGCFR 1233
            ..:       ||:..::.                :.::.:||   .|.|.:.:.........| |
Worm   707 PPL-------HVQPPVSQ----------------QNTVLLGGIEDTTTDSVNRCLHPRDSGNC-R 747

  Fly  1234 GLVV------NGEILDIYSYMS--------VHLSEIIKDC-KPSCVPSP-------CRN---GAQ 1273
            |..|      ..:..|:::|..        ....|.:..| ||...||.       |.|   ..:
Worm   748 GQFVRWFFDDEKKNCDVFTYTGCQGNGNNFASKEECMAICHKPEPTPSATPDFSQVCSNDVDAGE 812

  Fly  1274 CKELWS--SFKCVCNNPWAHIGEFCETNINEKALTFINRESFLMRNYLSVGATPVILMHGINGER 1336
            |..::.  :|.....:..|.....|..|.|    .|...:....|..:::..:||...     |.
Worm   813 CNGVFERFAFDAEAQDCRAFTYGGCGGNGN----NFATMQECRSRCVMAMKKSPVATC-----EA 868

  Fly  1337 DV----LKGILNQ---DLLIN-LRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVN 1393
            |:    ..|:.::   |..|| .|::....    ...:.|||..|....|:           .||
Worm   869 DIEVGECAGVFSRFAFDKSINACRSFTYGG----CGGNANNFATLQECTNK-----------CVN 918

  Fly  1394 LTLLDDTLMASLKSIQVAIVRGEQETRMHVNEHS-------------------VSIDRGTL---- 1435
            ..:..:.........|:            ||:.|                   .||.:.:|
Worm   919 RGVCPEPPACDTNRCQL------------VNDRSGCPFCSCPPVKQASPPGSITSIPKESLPNCP 971

  Fly  1436 LLDEYANKP----WSNPE--KEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGC 1494
            .||..|.:.    :.|.:  :|.:.|...|.||      ||    |..  ||.....|.......
Worm   972 PLDRSACRDPCMMFHNRQGCEECICPQTAPTPP------HV----PTG--RPTTVGQAQPPASSS 1024

  Fly  1495 VRGLKIGAQLIDLAD---------------INERNIAPTQEGVLPN------CQI--KC----DA 1532
            .|..::|.......:               :|......|:...|||      .||  ||    :.
Worm  1025 RRVTEVGPPAPRTTEAAPPAPSSQPPRQFAVNTLQHQQTKPDQLPNLPRNLAAQIEEKCLQPVEP 1089

  Fly  1533 EPCKN----------GGTC-----------QEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGES 1576
            .||||          .|||           :.||..| ..|:.....||       .|:..|..|
Worm  1090 GPCKNFADRWYFNVDDGTCHPFKYGGCAGNRNHFFTQ-KECEVHCARFL-------SGSPTSSTS 1146

  Fly  1577 TLQR--KFELPGTGRVDYVRLQLAFSSFDLRRANRIMLLMQTEAERSYYL----LLAITSDGYLQ 1635
            .|.:  ||. |.|...     :.:.|:.|:..:::...|....|.:.:..    :......|...
Worm  1147 ALPKHAKFS-PTTSET-----ESSTSAEDVESSSKNEELEAFPAPKLHRQFASPIFKPVGPGPQA 1205

  Fly  1636 LEEDR-DNGQTVGARIDRNFLNSARHSVYYVRNGTQSQLFIDREQVPLSEFAARVLTTGGDAGS- 1698
            .:.:: ||.......::...|:...|..|:..||.      |:.|       .|..:.|...|:
Worm  1206 YDSEKIDNYSPPTPNVNLVGLSPPVHPTYFTYNGQ------DQGQ-------RRAFSAGQQQGAE 1257

  Fly  1699 NRVQIGGINSTDSRFAVFKSYSGCL-----SNIYIQVNGHV---------------MKPLEEY-M 1742
            ||:::|      .:...|.|....|     .|.::|..|..               .:||||. :
Worm  1258 NRIEVG------QQLEAFGSQRPQLPTHLQGNNFVQGRGRFDGRQRFEVPQGSTSPSQPLEEIPV 1316

  Fly  1743 LFTKSGADNITVIN-PQGVRSAQCNAKFDVSEQPTQEPMVNVSMI-------PEPWVEEP----- 1794
            ..::...||..... |||.:    ..:...|..|: ||:.::.::       ....||.|
Worm  1317 TQSRERFDNRQRAEAPQGSQ----RQEHQTSTAPS-EPLEHIPVVQSRGRFDSRQRVEVPQESIR 1376

  Fly  1795 PARVPYIPRFVYDENKQEDSTQVVFLTLTSVFVIIVICCLLEVYRSHLAYKKRIERETDEDII-- 1857
            ||....|||.:.|......|:.                      ||     .::.|.::.:|:
Worm  1377 PAEATTIPRHLGDVTTSTSSSS----------------------RS-----SQVSRASEPEIVRP 1414

  Fly  1858 ---------WSKEQATKMHESPGVKAG--------------LLGGVTAGSGNGLPPYTYKAL-PQ 1898
                     :..:..|:..|.|..:..              .:.|||:.:.:  ...|.::. |.
Worm  1415 RAPEPPQSRFHPKTVTRTEEVPTPRGAETFGRSTQQVTVQPRVAGVTSSTRD--QEATRRSQGPA 1477

  Fly  1899 EDKKPGNGAPLVGILKNGSATPSQPGTPTALSKNGDIASRIEEEEEEEDEAPAQKAAEKSGENEE 1963
            |..:..:.||...|:.:..::...|.|||                :|..:.|.:.....:|...:
Worm  1478 ESVRVPSRAPETSIIGHQVSSFQSPSTPT----------------QETSKFPHRFVTPSTGSQTK 1526

  Fly  1964 PPAKDTTAS--------------EI------KESQAQPPEQLAKDTTDASAAPKASKETEAQAE- 2007
            .|...||::              |:      |.:|.|.|.:...|.|         :.|....:
Worm  1527 TPWYQTTSAPWWLQSPATSKKKPELKIEKLEKSNQQQLPARFNFDPT---------RYTFYNGDY 1582

  Fly  2008 --PSEPSSQLNSAQNGQL-AQMEQAARGDEV-------QVPSLPHPIQPPDAIFMPNLPQKAQQR 2062
              |:.|..::|..|.|.| .|....:.||.:       |...|....|.....|:..  :|...|
Worm  1583 FGPTIPGIRINKTQEGGLFVQGGSVSEGDNLEAQEAFEQFKQLSKGFQQQANEFLRQ--EKKAGR 1645

  Fly  2063 QPQE----------------HKSRHKATDDTEAPKQQQQQQQQQQSFDVATNANGSSLPASRVKN 2111
            .||.                |....::.::.|.|:.:........:..:......|.|||.|
Worm  1646 TPQHGSFIIGSVKVGDNEGIHDDEDESLEEQEHPRSRAHGVPIHPTVPLVVPTYSSPLPAVR--- 1707

  Fly  2112 PEEPGGK-SPLVPMRQHHSKVTRPPPPPTLFLENSLLQRQFANP 2154
              .|.|| ..|..:..|..  ..||.|.||.:...:...|...|
Worm  1708 --GPNGKIEGLETIAAHQE--AHPPAPSTLIVPRRIQGFQVTRP 1747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389
		Laminin_G_2	698..817	CDD:280389
		EGF_CA	842..878	CDD:238011	8/37 (22%)
		Laminin_G_2	1112..1240	CDD:280389	23/140 (16%)
		EGF_CA	1256..1297	CDD:238011	10/53 (19%)
		Laminin_G_2	1351..1503	CDD:280389	32/180 (18%)
		LamG	1612..1733	CDD:304605	23/131 (18%)
mlt-11	NP_001256938.1	TY	<361..409	CDD:238114
		KU	429..473	CDD:238057	12/44 (27%)
		Lustrin_cystein	483..521	CDD:291299	11/79 (14%)
		Kunitz_BPTI	538..590	CDD:278443	11/55 (20%)
		KU	735..787	CDD:238057	7/52 (13%)
		KU	803..855	CDD:294074	10/55 (18%)
		KU	864..917	CDD:238057	12/72 (17%)
		Kunitz_BPTI	1083..1133	CDD:278443	12/50 (24%)
		Kunitz_BPTI	2176..2228	CDD:278443
		Kunitz_BPTI	2240..2291	CDD:278443
		Lustrin_cystein	2608..2649	CDD:291299
		KU	2740..2793	CDD:238057
		Lustrin_cystein	2910..2956	CDD:291299
		Kunitz_BPTI	3070..3128	CDD:278443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910