DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment axo and itx-1

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:NP_001249244.2 Gene:itx-1 / 171846 WormBaseID:WBGene00002174 Length:1645 Species:Caenorhabditis elegans


Alignment Length:1991 Identity:433/1991 - (21%)
Similarity:744/1991 - (37%) Gaps:569/1991 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 IFAK-NNTFIQMDGD---IIQTFQLRLCREISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVI 305
            ||.| .::|:....|   :.:| ..:|...:.||..:.:  |.:......|||            
 Worm    27 IFLKYPSSFVNFTSDNWKLTET-DNQLIIAVKFQASSHI--GQIFSVRFINPD------------ 76

  Fly   306 VEKGQLKV------------VHVFGKHSTSVTVGESLNRDEWHSVMVRIDVHGARLIARVDNSQE 358
               |.||.            ::::...:|.:     ||:...:|   .|:||...|...::.:..
 Worm    77 ---GSLKALLTAGIAAGILQINLYDDKNTKI-----LNKPMENS---PINVHEHSLAVGLNTTAR 130

  Fly   359 EVYLK-----GLNHEYNYGVS-TNLPSVVLVGGLSSEEKLHGVKYITESFVGCIRNVVLSSGKAA 417
            .::.|     .||.|.|..:. :|....|.:||.|            :|.:||:..|.:|:|:::
 Worm   131 NLWYKLGADNDLNCEINQAIDISNTEVTVTIGGGS------------QSMIGCVSIVAVSAGESS 183

  Fly   418 SDLLPIAPLVATKHENVNEGC--SDMCESRHNLCFVGSRCINHYGGISCDCFGTHYEGEHCDIYT 480
                |::......:::::| |  :|.|.::.  |..| ||| .....:|||:||...|.:|.: .
 Worm   184 ----PVSQGTPIAYQDIDE-CPKADACTTKD--CNTG-RCI-QLEVPTCDCYGTEMAGPNCRL-P 238

  Fly   481 ATIITLR-------GASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDS-----ALFYASGESLKH 533
            |..|.||       .::|:.|:  .|:...|.|  |:|:.||  |.||     .|.|  ||:.:.
 Worm   239 APTIQLRNNDENEESSAYLRYK--PWEMDSHFS--RLSMDFR--FSDSDAKEGILVY--GETSQG 295

  Fly   534 QYIAASIKNQSVHVEMDFGDNVMSTVLTDDLTRGYWHNLTILHEQRTVSIILDQQQKVLELPATA 598
            :.....:......|.:| ..||....|.:|      |  :|.|     |||:    |:::    .
 Worm   296 KIFKIYVVGTKGKVMLD-TTNVADFELRED------H--SIFH-----SIIV----KIVD----G 338

  Fly   599 SGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEF 663
            ..|||.|..:        |::    :.|.          :|..:...:|.|.|            
 Worm   339 IFNMLVDDNV--------HRR----AFNE----------SDALVFDTIQFGAP------------ 369

  Fly   664 VENEVNVIPITYPFATSHIWWPINHAEEFNIKFDFRSSRPGAVLAYSDVTTSAGNGFWEIRLTSD 728
            :..:|:.:.:|  ....:::  ::|.:...:          |||.....||:             
 Worm   370 IPTDVSEVGVT--ACVKNVY--VDHVDIIEL----------AVLTNDSRTTA------------- 407

  Fly   729 KLSFDLVPDVNNNVTHSTTIKINRATSWHSVELDYKLGEIRFTVDYRHTLSQMYGLTFNIGDKLI 793
                                  :|..|.::.:|....|...|:.|   .|:::            
 Worm   408 ----------------------SRVRSCNNEDLTEFQGPSLFSAD---PLAEI------------ 435

  Fly   794 IGSSLKSAAMGLVGCIRDIEINGHLIEPRHVVKTERVVGEVALDNCNYIDPC-KRPNT------- 850
                                    |:|....:|:|  .||..:....:..|. |:|.|       
 Worm   436 ------------------------LVEDPSDIKSE--FGESVIGADMFPVPSNKKPKTQPLSSCE 474

  Fly   851 ------CEHGGKCFVKDD-RVTCDCKHTGYIGKNCHFTKYRKTCEELALLGFTK--SDVYLIDID 906
                  |::|..|..:.: ..||.||. |||||.|.||...::|.|  ...|.|  :....:|:|
 Worm   475 KANAYMCQNGAGCKKESETEFTCFCKE-GYIGKFCQFTTIPRSCAE--AYDFLKLPNGATWVDVD 536

  Fly   907 GNGVFPPAHVKC-DFQSLENATKTIVEHNLPSQVDVRSARESDFS-FNIRYREFSPHMLQELISH 969
            ||....|:...| |.|       |.:.|::.....||.....:.| |.:.||:|:...|.:.|.:
 Worm   537 GNRKLDPSVTMCTDGQ-------TEIPHDMKPGYVVRDTTYQNHSLFVLSYRDFNSWQLAKYIKN 594

  Fly   970 SLYCTQYIKYDCYRAQLEL-HSATWFTSSAKNLT-----VDFLGNVKRGACPCSVNKTCVDPNQS 1028
            |..|:|.:.|.|.:|.|.. ...||| .|..|.|     :..|.|    :||| :::.| ...:.
 Worm   595 SGSCSQTVNYRCNKAPLRFKEGKTWF-KSVSNATEKIKQIGMLPN----SCPC-LDRGC-QSGEK 652

  Fly  1029 CNCDVKENKWNSDEGYYQDPQSLGITNMY--FLQQKDMDDEAQGR--ITLGPLECVETNTQKYVV 1089
            ||||  ....:.|.|        .:|..|  ..:...:.|||..|  :|:..|:|.....:| .:
 Worm   653 CNCD--SGAISEDIG--------ELTGRYSGICEVVTLFDEADVRAEMTISELKCSGYENEK-PI 706

  Fly  1090 TFTTSQSYIEVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQLTFTFTLSTGT 1154
            .| |.::.:::..|....|...||||...|.|:   .::.:|...:::::    ||...|:....
 Worm   707 RF-TERTELKISDWTGESIDLQFRTTETPASLV---TVQGNYGEKIISVS----LTDGHTVQISN 763

  Fly  1155 TREL-VINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLLPEEEFGPFEGSMYIGGATFDL 1218
            ...| :|.|..:||...||.:.|:.....:|..::..:.::.:   .:....|||:.:||.    
 Worm   764 FEALKIIESQTKLNDSNWHHVLIELADGEIRVTVDATHVLMTI---GDNAVLEGSVVLGGE---- 821

  Fly  1219 LKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIK---------DCKPSCVPSPCRNGAQC 1274
                  ..|||||.|.:::|.|        .|:|.||:|         .|...|....|:|||:|
 Worm   822 ------GDGLIGCVRNVLINDE--------PVNLQEIVKTSEKTGITETCDTRCTADFCQNGAKC 872

  Fly  1275 KELWSSFK--CVCNNPWAHIGEFCETNINEKALTFINRESFLMRNYLSVGATPVILMHGINGERD 1337
            .|.:.|..  |.|..|..|.|..||.:||..:                     .:..||...:.|
 Worm   873 YEDFVSGMPFCQCAFPDVHSGVNCEIDINTNS---------------------SVSFHGGYLKFD 916

  Fly  1338 VLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTL--LDDT 1400
            .:|.:||..:..:.||..|:||:.:|:|..|||:.:::|....:....|..|.:...|:  ...|
 Worm   917 DVKNVLNAPIYFSFRTDRTHALLFFAHDQNNNFLQVHLSEEVNVTLTLNNLDIVSQCTVRAQPGT 981

  Fly  1401 LMASLKSIQVAIVRGEQETRMHVNEHSVSIDRG--------TLLLDEYANKPWSNPEKEVLSPHR 1457
            ....::.|||||....:.:::.|::.:.:|...        |.|||.|.::....|....     
 Worm   982 EYGDMRWIQVAITHDSKSSQLQVDDAACTIRTSRVLSEIPITRLLDVYNSELVGMPVGLA----- 1041

  Fly  1458 PPAPPTEYFQFHVGGY--------------------------------DPANLLRPNVDAPALEG 1490
            .|..|..|....:|..                                |.:.:|.|..::| :..
 Worm  1042 APVKPNPYTFTFIGNVNTGEKTNGKRLLFSDCLPRRRSPSIFLMLIFPDGSFILAPKYESP-IPR 1105

  Fly  1491 YIGCVRGLKIGAQLIDLADINERNIAPTQ--EGVLP-----NCQIKCDAEPCKNGGTCQEHFAE- 1547
            :.||:||.:|..::||:.:..| ::|.::  |...|     .|::.|.:..|.|||.|...:|. 
 Worm  1106 FYGCIRGFQINREMIDMREKTE-HLATSEMYEAYGPALVKVGCEVGCSSITCLNGGHCSVAWANT 1169

  Fly  1548 ----QLSTCDCEHTSFLGEFCSEEKGA----------DFSGEST----LQRKFELPGTGRVDYVR 1594
                ..:||||..||:.|..||.::|.          |.|.|..    :::..::|..       
 Worm  1170 DPSAATTTCDCSRTSYTGASCSLDEGVHMERSGFIEFDISKEMARYVFIEQNSKIPQL------- 1227

  Fly  1595 LQLAFSS---FDLRRANRIMLLMQTEAERSYYLLLAITSDGYLQLEEDRDNGQTVGARIDRNFLN 1656
            |:.||||   ..|:..:.:.|::..|.::   |.:.|..:..:.:....:||::.......:||:
 Worm  1228 LKFAFSSSPEIVLKDKSMLALVVFREKQK---LEIEINPNRTINVAITYENGKSDVLNFVGDFLD 1289

  Fly  1657 SARHSVYYVRN-GTQSQLFIDREQVPLSEFAARVLTTGGDA-----GSNRVQIGG-----INSTD 1710
            ..||.|....| .:.:.:.||..:   .:|..|    |.|.     .:.|::|||     ...||
 Worm  1290 GYRHFVVVQTNQASATAVMIDSLR---QDFEYR----GKDKNIDLFNAERIRIGGGPRDRYTETD 1347

  Fly  1711 SRFAVFKSYSGCLSNI---YIQVNGHVMKPLEEYMLFTKSGADNIT-----VINPQGVRSAQCNA 1767
            .....  .|:||:||.   |.:.:....||:..:.        |.|     :|....:....| |
 Worm  1348 GYLKA--GYTGCISNFIVDYQRGSSLTYKPITYFA--------NPTHHLSKLIMTNRIVLGGC-A 1401

  Fly  1768 KFDVSEQPTQEPMVNVSMIPEPWVEEPPARVPYIPRFVY--------DEN----KQEDSTQ---V 1817
            .|:|   |...|:....:....|..|       ..||||        |.|    ..|||..   |
 Worm  1402 AFEV---PNSLPVYQNRVKFPVWDTE-------FRRFVYFRDVEPLNDNNDTEWTDEDSGSLMWV 1456

  Fly  1818 VFLT-LTSVFVIIVICCLLEVYRSHLAYKKRIERETDEDIIWSKEQATKMHESPGVKAGLLGGVT 1881
            ||:. :..|..:|:.|..::..|..: :.:..|...||||        .:|.:|           
 Worm  1457 VFIIFVLGVIFLIIFCIFMKCCREKI-HARDDEYLHDEDI--------PLHMAP----------- 1501

  Fly  1882 AGSGNGLPPYTYKALPQEDKKPGNGAPLVGILKNGSATPSQPGTPTALSKNGDIASRIEEEEEEE 1946
                      |....||....|         :|..:|:..:...|     |.|.......:.::|
 Worm  1502 ----------TILRHPQPSPPP---------IKKSAASNYKIPNP-----NIDFNKENTFDYDDE 1542

  Fly  1947 DEAPAQKAAEKSGENEEPPAKDTTA-SEIKESQAQPPEQLAKDTTDASAAPKASKETEAQAEPSE 2010
            ||.        :|..::....|.|. :|:.:|..:....:..:..|.......|:.|:....|  
 Worm  1543 DEF--------AGIADDNVTDDVTVRNEVDDSDNETIRHIDDEVQDEDGMVIVSRPTQVSHLP-- 1597

  Fly  2011 PSSQLNSAQNGQLAQMEQAARGDEVQVPSLP-H---PIQPP 2047
              .:::|.:.|.....:.:.....::.|:.| |   |:.||
 Worm  1598 --QRVSSFRTGDPTAPKDSPLYSNIRPPTSPIHASVPVPPP 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 29/153 (19%)
EGF_CA 433..476 CDD:238011 15/44 (34%)
Laminin_G_2 514..640 CDD:280389 28/130 (22%)
Laminin_G_2 698..817 CDD:280389 12/118 (10%)
EGF_CA 842..878 CDD:238011 16/50 (32%)
Laminin_G_2 1112..1240 CDD:280389 31/128 (24%)
EGF_CA 1256..1297 CDD:238011 15/51 (29%)
Laminin_G_2 1351..1503 CDD:280389 41/193 (21%)
LamG 1612..1733 CDD:304605 30/134 (22%)
itx-1NP_001249244.2 LamG 254..389 CDD:238058 41/202 (20%)
EGF 481..507 CDD:278437 11/26 (42%)
LamG 705..835 CDD:238058 34/150 (23%)
LamG 905..1052 CDD:238058 37/151 (25%)
LamG <1268..1364 CDD:304605 25/104 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 42 1.000 Domainoid score I8470
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 251 1.000 Inparanoid score I1997
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171014at33208
OrthoFinder 1 1.000 - - FOG0014339
OrthoInspector 1 1.000 - - oto17719
orthoMCL 1 0.900 - - OOG6_115576
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R17079
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.900

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