DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and Cntnap4

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_569724.2	Gene:	Cntnap4 / 170571	MGIID:	2183572	Length:	1310	Species:	Mus musculus

Alignment Length:	1186	Identity:	280/1186 - (23%)
Similarity:	481/1186 - (40%)	Gaps:	196/1186 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR--ISLMFRTNFDDSAL 523
            |:..:.||       | .|.:.:|.|.|.|.:.||.    |:...|..|  |||.|:|...|..|
Mouse   171 GMRIEVFG-------C-AYRSVVIDLDGKSSLLYRF----DQNSLSPIRDIISLKFKTMESDGIL 223

  Fly   524 FYASGESLKHQYIAASIKNQSVHVEMDFGD-NVMSTVLTDDLTRG------YWHNLTILHEQRTV 581
            .:.:|.:..|  |...::...:.:.::.|| .:.|:....:||.|      :||::.|....:.|
Mouse   224 LHRAGPAGDH--ITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQV 286

  Fly   582 SIILDQQQKVLELPATASGNML-FDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYE 645
            :..:|:.::  ...|....|.| .|.||.|||.....|...| .:.:|.|.|:.::||.:.::..
Mouse   287 NFTVDEHRR--HFHAQGEFNYLDLDYEISFGGISAPAKSVSL-PYKHFHGCLENLFYNGVDVIGL 348

  Fly   646 LQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWPINHAEE-FNIKFDFRSSRPGAVLAY 709
            ::..:|::...|  .|.|..::...:|:|:....|::..|.:..|| .:..|.||:.....:|.:
Mouse   349 VKEHSPQIITMG--NASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLF 411

  Fly   710 SDVTTSAGNGFWEIRLTSDKLSFDLV-PDVN-NNVTHSTTIKINRATSWHSVELDYKLGEIRFTV 772
            |::...:|:..  :.|:..||...|. |..: :::|....:...:   ||||.|..|...:...|
Mouse   412 SELQLVSGSLL--LLLSDGKLKLTLYQPGKSPSDITAGAGLGDGQ---WHSVSLSAKRNHLSVVV 471

  Fly   773 DYRHTLSQMY--------GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPRHVVK 826
            |...:.:..:        |..|..|   || ..||..||...|..||:|.|.||..:::  .:..
Mouse   472 DGHISPASPWLGPEQVNSGGVFYFGGCPDK-GFGSKCKSPLGGFQGCMRLISINNKMVD--LIAV 533

  Fly   827 TERVVG---EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCE 888
            .:..:|   ::.:|:|...|.| .||:|||||:|........|:|.:|||.|..||.:.|.::||
Mouse   534 QQGALGNFSDLQIDSCGISDRC-LPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCE 597

  Fly   889 ELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNI 953
            .....| ..|..|.||.||:|...|..:.|   ::.....|:::||....:.||:....:....:
Mouse   598 AYKHQG-NASGFYYIDSDGSGPLQPFLLYC---NMTETAWTVMQHNGSDLMRVRNTHSENAHTGV 658

  Fly   954 RYREFSPHMLQELISHSLYCTQYIKYDCYRAQL----ELHSATWFTSSAKNLTVDFLGNVK-RGA 1013
            .....|...||..|:.:.:|.|.:.|.|.:::|    :....:|:..........:.|::. ...
Mouse   659 FEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPVHQK 723

  Fly  1014 CPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITLGPLE 1078
            |.|.:...|:|....||||...|:|.:|.|:....:.|.:|.:..........||..:  ||||.
Mouse   724 CTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYK--LGPLL 786

  Fly  1079 CVETNTQKYVVTFTTSQSYIEVP---GWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTG 1140
            |..........:|.|..||:..|   |....|::|.|:||....:.|....|...   ..:.|..
Mouse   787 CRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITDF---IRIELRS 848

  Fly  1141 DDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLLPEEEFGPF 1205
            ...:||:|.:..|.. ||.::|....|..:||.:.::.|.......::      :|.|:.:..|.
Mouse   849 PTTVTFSFDVGNGPF-ELSVHSPTHFNDNQWHHVRVERNMKEASLRVD------ELPPKIQAAPT 906

  Fly  1206 EG--------SMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPS 1262
            :|        .:::||..       :.:.|.:||.|.|.:||..||:....:| ...:...|:..
Mouse   907 DGHVLLQLNSQLFVGGTA-------TRQRGFLGCIRSLQLNGMALDLEERATV-TPGVQPGCRGH 963

  Fly  1263 C--VPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNINE-----KALTFINRESFLMRNYLS 1320
            |  ....||:|.:|:|..|.|.|.|::. |:.|.||...|:.     .::.:..:|::.:....|
Mouse   964 CGSYGKLCRHGGKCREKPSGFFCDCSSS-AYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSS 1027

  Fly  1321 VGATPVILMHG-INGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFL 1384
            ..|..   .|| :...|:::|        .:.||....:|:|:.:..|..::.:.|:.|..:...
Mouse  1028 FHAAS---FHGDMKLSREMIK--------FSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQIR 1081

  Fly  1385 YNYGDEIVNLTLLDDTLMASLKSI------QVAIVRGEQETRMHVNEHS---VSIDRGT------ 1434
            |.     :|.....|.:...|||:      .:.|.|.|....:.::|::   ..:..||
Mouse  1082 YK-----LNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVK 1141

  Fly  1435 -LLLD---EYANKPWSN---------------------PEKEVLSPHRPPAP------------- 1461
             |:|.   ||::.....                     |.|..|.| .||||
Mouse  1142 SLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQP-GPPAPVTVTGHVTESSCV 1205

  Fly  1462 -----------PTEYFQFHVGGYDPANLLRPNV--DAPALEGYIG-------CVRGLKIGAQLID 1506
                       .|..|..|.|..|....|...:  |:..:.|.|.       ||..  |..::..
Mouse  1206 APSGTDATSRERTHSFADHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSA--IAVRIYQ 1268

  Fly  1507 LADINERNIAPTQEGV 1522
            ...:.:||.|...|.|
Mouse  1269 QKRLYKRNEAKRSENV 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	34/133 (26%)
		Laminin_G_2	698..817	CDD:280389	35/131 (27%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:280389	29/135 (21%)
		EGF_CA	1256..1297	CDD:238011	14/42 (33%)
		Laminin_G_2	1351..1503	CDD:280389	43/224 (19%)
		LamG	1612..1733	CDD:304605
Cntnap4	NP_569724.2	FA58C	56..178	CDD:238014	1/6 (17%)
		FA58C	57..179	CDD:214572	3/14 (21%)
		Laminin_G_2	214..343	CDD:280389	34/133 (26%)
		Laminin_G_2	400..526	CDD:280389	35/131 (27%)
		EGF	555..586	CDD:278437	15/31 (48%)
		FReD	597..>645	CDD:294064	14/51 (27%)
		LamG	796..940	CDD:238058	36/160 (23%)
		Laminin_G_2	1048..1178	CDD:280389	23/134 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12035
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920