DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axo and CNTNAP5

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001354427.1	Gene:	CNTNAP5 / 129684	HGNCID:	18748	Length:	1307	Species:	Homo sapiens

Alignment Length:	1146	Identity:	270/1146 - (23%)
Similarity:	479/1146 - (41%)	Gaps:	177/1146 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRR-ISLMFRTNFDDSALF 524
            |:..:.:|..|:.:..|        ..|.|.:.||   :..::.|:.:. |||.|::...|..||
Human   166 GMRVEVYGCSYKSDVAD--------FDGRSSLLYR---FNQKLMSTLKDVISLKFKSMQGDGVLF 219

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGD-------NVMSTVLTDDLTRGYWHNLTILHEQRTVS 582
            :  ||..:..:|...::...:.:.::.||       ::.|..|...|...:||::.|....:.|:
Human   220 H--GEGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVN 282

  Fly   583 IILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQ 647
            ..:|:..:.......... :..|.|:.|||.| :..|.|.....||.|.::.:|||.::|:...:
Human   283 FTVDKHTQHFRTKGETDA-LDIDYELSFGGIP-VPGKPGTFLKKNFHGCIENLYYNGVNIIDLAK 345

  Fly   648 RGNPKVHYHGVLEAEFVENEVNVIPITYPFAT-SHIWWP-INHAEEFNIKFDFRSSRPGAVLAYS 710
            |...:::..|  ...|..:|..::|||:..:: |::..| ....:..::.|.||:.....:|..:
Human   346 RRKHQIYTVG--NVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLST 408

  Fly   711 DVTTSAG-------NGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVELDYKLGEI 768
            :::..:|       .|.  :||...|:: :.|.::      .|...:|... ||||.::.:...|
Human   409 ELSEGSGTLLLSLEGGI--LRLVIQKMT-ERVAEI------LTGSNLNDGL-WHSVSINARRNRI 463

  Fly   769 RFTVDYR-------HTLSQMY-GLTFNIG---DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPR 822
            ..|:|..       .|..|:| |.::..|   |.| ..|...:......||:|.|.|:.   :|:
Human   464 TLTLDDEAAPPAPDSTWVQIYSGNSYYFGGCPDNL-TDSQCLNPIKAFQGCMRLIFIDN---QPK 524

  Fly   823 HVVKTER----VVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKY 883
            .::..::    ...::.:|.|:..|.| .||.|||||.|........|:|..|.|.|..||.:.|
Human   525 DLISVQQGSLGNFSDLHIDLCSIKDRC-LPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHNSIY 588

  Fly   884 RKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSAR-ES 947
            .::||.....|.|....| ||.||:|...|..|.|:.  .|:...|.|:||......||.|. |.
Human   589 EQSCEVYRHQGNTAGFFY-IDSDGSGPLGPLQVYCNI--TEDKIWTSVQHNNTELTRVRGANPEK 650

  Fly   948 DFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSA-----TWFTSSAKNLTVDFLG 1007
            .::..:.|.. |...|:.:|..|.:|.|.:.|.|.|::| |::.     ||:...: |....:.|
Human   651 PYAMALDYGG-SMEQLEAVIDGSEHCEQEVAYHCRRSRL-LNTPDGTPFTWWIGRS-NERHPYWG 712

  Fly  1008 NVKRGA--CPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQG 1070
            ....|.  |.|.::::|:|....||||..:::|.:|.|:......|.:|.:........:.||..
Human   713 GSPPGVQQCECGLDESCLDIQHFCNCDADKDEWTNDTGFLSFKDHLPVTQIVITDTDRSNSEAAW 777

  Fly  1071 RITLGPLECVETNTQKYVVTFTTSQSYIEVPGWR---KGDIAFSFRTTGEKAILLFQPPIRPHYP 1132
            ||  |||.|.........|:|.|..||:..|.:.   ..||:|.|:||....:.|....|:..
Human   778 RI--GPLRCYGDRRFWNAVSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIKDF-- 838

  Fly  1133 SFMVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLL 1197
             ..:.::...::||...:..|.. |||:.|...||..:||.:..:.|      :..|..| :|.|
Human   839 -IRLEISSPSEITFAIDVGNGPV-ELVVQSPSLLNDNQWHYVRAERN------LKETSLQ-VDNL 894

  Fly  1198 PE-----EEFGPF----EGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLS 1253
            |.     .|.|.|    ...:::||.:       |.:.|.:||.|.|.:||:.:|:.....| .|
Human   895 PRSTRETSEEGHFRLQLNSQLFVGGTS-------SRQKGFLGCIRSLHLNGQKMDLEERAKV-TS 951

  Fly  1254 EIIKDCKPSC--VPSPCRNGAQCKELWSSFKCVC-NNPWAHIGEFCETNINE-----KALTFINR 1310
            .:...|...|  ..|.|.||.:|.|..:.:.|.| |:|:.  |.||:..::.     .::|::.:
Human   952 GVRPGCPGHCSSYGSICHNGGKCVEKHNGYLCDCTNSPYE--GPFCKKEVSAVFEAGTSVTYMFQ 1014

  Fly  1311 ESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLLINLRTYDTNALVLYANDHYNNFVHLYI 1375
            |.:.:...:|:.::.:......:.|          ::.::..|....:|:|:.|....:||.:.:
Human  1015 EPYPVTKNISLSSSAIYTDSAPSKE----------NIALSFVTTQAPSLLLFINSSSQDFVVVLL 1069

  Fly  1376 SLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIVRGEQETRMH---VNEHSVSIDRGTLLL 1437
            ..|..:...|:...|..::..:|....|:              .|||   :|.....:   |:.:
Human  1070 CKNGSLQVRYHLNKEETHVFTIDADNFAN--------------RRMHHLKINREGREL---TIQM 1117

  Fly  1438 DEYANKPWS-NPEKEVLSPHRPPAPPTEYFQFHV-----GGYDPANL-LRPNVDAPALEGYIGCV 1495
            |:.....:: :||.|                |.|     .|....|| |...|......|:.||:
Human  1118 DQQLRLSYNFSPEVE----------------FRVIRSLTLGKVTENLGLDSEVAKANAMGFAGCM 1166

  Fly  1496 RGLKIGAQLIDLADINERNIAP-TQEGVL--PNCQIKCDAE 1533
            ..::........|.:....:|| |..|.|  .:|....|::
Human  1167 SSVQYNHIAPLKAALRHATVAPVTVHGTLTESSCGFMVDSD 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	3/14 (21%)
		Laminin_G_2	514..640	CDD:280389	31/132 (23%)
		Laminin_G_2	698..817	CDD:280389	31/136 (23%)
		EGF_CA	842..878	CDD:238011	15/35 (43%)
		Laminin_G_2	1112..1240	CDD:280389	34/136 (25%)
		EGF_CA	1256..1297	CDD:238011	14/43 (33%)
		Laminin_G_2	1351..1503	CDD:280389	30/161 (19%)
		LamG	1612..1733	CDD:304605
CNTNAP5	NP_001354427.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11662
eggNOG	1	0.900	-	-		E1_KOG3516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.780