DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axo and Aplp1

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_031493.2	Gene:	Aplp1 / 11803	MGIID:	88046	Length:	654	Species:	Mus musculus

Alignment Length:	541	Identity:	97/541 - (17%)
Similarity:	137/541 - (25%)	Gaps:	231/541 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  1759 GVRSAQCNAKFDVSEQPTQEPMVNVSMIPEPWVEEPPARVPYIPRFVYDENKQEDSTQVVFLTLT 1823
            |.||.:|       ..|..| :|....:|..:|.| ...||...||::.|...:
Mouse   122 GTRSGRC-------AHPHHE-VVPFHCLPGEFVSE-ALLVPEGCRFLHQERMDQ----------- 166

  Fly  1824 SVFVIIVICCLLEVYRSHLAYKKRIERETDEDIIWSKEQATKMHESPGVKAGLLGGVTAGSGNGL 1888
                     |                           |.:|:.|:.........|.:..|||..|
Mouse   167 ---------C---------------------------ESSTRRHQEAQEACSSQGLILHGSGMLL 195

  Fly  1889 P---------PYTYKALPQEDKKPGNGA--------PLVGILKNGSATPSQPGTPTALSKNGDIA 1936
            |         .|.....|......|..|        ||.|..:.|.........|..:.......
Mouse   196 PCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEP 260

  Fly  1937 SRIEEEEEEEDE-APAQKAAEKSGENEEPPAKDTTA----------------------SEIKESQ 1978
            .:.|||||||:| ||             ||:..|..                      .||.|.:
Mouse   261 PQAEEEEEEEEERAP-------------PPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHE 312

  Fly  1979 A-----------------QPPEQLAKDTTDASAAPKASK-------------------------- 2000
            .                 :...:.|...:.:...|||.:
Mouse   313 GFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLV 377

  Fly  2001 ETEAQAEPSEPSSQLNSAQNGQLAQMEQAARGDEVQVPSLPHPIQPPDA--IFMPNLPQKAQQRQ 2063
            ||.|....:..:.|..:|..|.||    |.:||            ||.|  :.|........:::
Mouse   378 ETHATRVIALINDQRRAALEGFLA----ALQGD------------PPQAERVLMALRRYLRAEQK 426

  Fly  2064 PQEHKSRH----KATDDTEAPKQQQQQQQQQQSFDVATNAN------------------------ 2100
            .|.|..||    .|.|..:|.:.:.|.|...|..:...|.:
Mouse   427 EQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLA 491

  Fly  2101 -------------GSS-------------------LPASRVKNPEEPGGKSPLVPMRQHHSKVTR 2133
                         |||                   ||...........|:..|.|:.|:..||..
Mouse   492 EHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNA 556

  Fly  2134 PPPPPTLFLENSLLQRQFANP 2154
            ..|....| .:|.:||....|
Mouse   557 SAPRGFPF-HSSDIQRDELAP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011
		Laminin_G_2	514..640	CDD:280389
		Laminin_G_2	698..817	CDD:280389
		EGF_CA	842..878	CDD:238011
		Laminin_G_2	1112..1240	CDD:280389
		EGF_CA	1256..1297	CDD:238011
		Laminin_G_2	1351..1503	CDD:280389
		LamG	1612..1733	CDD:304605
Aplp1	NP_031493.2	A4_EXTRA	46..211	CDD:128326	26/144 (18%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	50..146		8/31 (26%)
		APP_N	55..154	CDD:280358	11/40 (28%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	154..212		14/104 (13%)
		APP_Cu_bd	156..211	CDD:289676	14/101 (14%)
		Copper-binding	158..178		6/66 (9%)
		Zinc-binding. /evidence=ECO:0000250	204..211		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..297		20/95 (21%)
		APP_E2	289..471	CDD:289677	33/197 (17%)
		Heparin-binding. /evidence=ECO:0000250	314..346		1/31 (3%)
		Heparin-binding. /evidence=ECO:0000250	414..445		7/30 (23%)
		Collagen-binding. /evidence=ECO:0000250	446..463		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..580		17/81 (21%)
		Basolateral sorting signal. /evidence=ECO:0000250	608..619
		APP_amyloid	<612..651	CDD:287486
		Interaction with DAB1	636..652
		Interaction with DAB2. /evidence=ECO:0000269\|PubMed:11247302	640..654
		NPXY motif, contains endocytosis signal	644..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900