DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment axo and Nrxn3

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:XP_038967552.1 Gene:Nrxn3 / 116508 RGDID:620212 Length:1696 Species:Rattus norvegicus


Alignment Length:1962 Identity:399/1962 - (20%)
Similarity:666/1962 - (33%) Gaps:647/1962 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 EISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQLKVVHVFGKHSTSVTV--GESLNR 332
            ::||||:|.:..|||:|.:    |....|...|.::..:.||:    |.......||  .:.:|.
  Rat    50 DLSFQFKTNVSTGLLLYLD----DGGVCDFLCLSLVDGRVQLR----FSMDCAETTVLSNKQVND 106

  Fly   333 DEWHSVMVRIDVHGARLIARVDNSQEEV-----YLKGLNHEYNYGVSTNL-PSVVLVGGLSSEEK 391
            ..||.:||..|.....|:...:....|:     |:..::..:..||..:: ||.:.:.|:.:...
  Rat   107 SSWHFLMVSRDRVRTGLVIDGEGQSGELRPQRPYMDVVSDLFLGGVPADIRPSALTLDGVQNMPG 171

  Fly   392 LHGVKYITESFVGCIRNVVLSSGKAASDLLPIAPLVATKHENVNEGCSDMCESRHNLCFVGSRCI 456
            ..|:.            :.|..|.:...||        ..::|.......|..|.  |..|..|.
  Rat   172 FKGLM------------LDLKYGNSEPRLL--------GSQSVQLEAEGPCGERP--CENGGICF 214

  Fly   457 NHYGGISCDCFGTHYEGEHC--DIYTA-------------------TIITLRGASYVSYRIYDWK 500
            ...|..:|||..|.|.|..|  |:...                   .:.|.||:.|:.|.:.  :
  Rat   215 LLDGHPTCDCSTTGYGGTLCSEDVSQGPGLSHLMMSEQGRSKAREENVATFRGSEYLCYDLS--Q 277

  Fly   501 DRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV---LTD 562
            :.:.||:..|:|.|:| :..:.|...:|:|.  .|:..::|:.:|.:.::.|......:   :..
  Rat   278 NPIQSSSDEITLSFKT-WQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAFEAIVEPVNG 339

  Fly   563 DLTRGYWHNLTIL----------HEQRTVSI--ILDQQQKVLELPATASG------NML-FDPEI 608
            ......||::.:.          |...|:|:  ||           |.:|      .|| .|...
  Rat   340 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGIL-----------TTTGYTQEDYTMLGSDDFF 393

  Fly   609 YFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQR----GNPKVHYHGVLEAEF-VENEV 668
            |.||.|......|....|||:|.||.|.|.:..|..||.|    |:.|:..:|  |..| .||..
  Rat   394 YVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYG--EVVFKCENVA 456

  Fly   669 NVIPITYPFATSHIWWP-INHAEEFNIKFDFRSSRPGAVLAYS--------DVTTSAGN--GFWE 722
            .:.||.:....::|..| .|.....:|.||||::.|..::.::        ||.:....  .|:.
  Rat   457 TLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDVRSQKNTKVDFFA 521

  Fly   723 IRLTSDKLSFDLVPDVNNNVTHSTTIKINRAT-------SWHSVEL--DYKLGEIRFTVDYRHT- 777
            :.|....|.  |:.|:.     |.|||: :||       .|:.|::  |.:.|.|  :|:.|.| 
  Rat   522 VELLDGNLY--LLLDMG-----SGTIKV-KATQKKANDGEWYHVDIQRDGRSGTI--SVNSRRTP 576

  Fly   778 ------------LSQMY--GLTFNIGDKLIIGSSLKSAAM--GLVGCIRDIEINGHLIEPRHVVK 826
                        ...||  ||..|... ||:.:.|.:|.:  |.||||||:.|:|.....|.:.:
  Rat   577 FTASGESEILDLEGDMYLGGLPENRAG-LILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAE 640

  Fly   827 TERVVG------EVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRK 885
            .:...|      .::...|:.. |||....|:.|...|:      |||..|||.|:.|.      
  Rat   641 MQNAAGVKSSCSRMSAKQCDSY-PCKNNAVCKDGWNRFI------CDCTGTGYWGRTCE------ 692

  Fly   886 TCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFS 950
              .|.::|.:..| :|:                         |.|:...:.::.:       |.|
  Rat   693 --REASILSYDGS-MYM-------------------------KVIMPMVMHTEAE-------DVS 722

  Fly   951 FNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGNVKRGACP 1015
            |             ..:|...|              .|..||....||..|.::..|    |...
  Rat   723 F-------------RFMSQRAY--------------GLLVATTSRDSADTLRLELDG----GRVK 756

  Fly  1016 CSVNKTCVDPNQSCNCD-----------VKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQ 1069
            ..||..|:..|  ||..           :.:|:|::.. ..:..:||.:|       .| ||.|:
  Rat   757 LMVNLDCIRIN--CNSSKGPETLYAGQKLNDNEWHTVR-VVRRGKSLKLT-------VD-DDVAE 810

  Fly  1070 GRIT-----------------------------LGPLECVETNTQKYV----------------- 1088
            |.:.                             :|.|:.:..|...|:                 
  Rat   811 GTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARF 875

  Fly  1089 ---------VTFTTSQSYI---EVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGD 1141
                     |||.|..||:   .:..:....:.|.|:||.....:||.              :||
  Rat   876 GLRNIIADPVTFKTKSSYLTLATLQAYTSMHLFFQFKTTSADGFILFN--------------SGD 926

  Fly  1142 DQ-----------LTFTFTLSTGTTRELVI--NSHRRLNGGEWHKIWI--DYNQYH--------V 1183
            ..           :.:.|.|..|..   ||  ||.|.||..:||.:.|  |.:..|        |
  Rat   927 GNDFIAVELVKGYIHYVFDLGNGPN---VIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVV 988

  Fly  1184 RFMINTDYQMLDLLPEEEFGPFEGSMYIGGAT----FDLLKKLSVKAGLIGCFRGLVVNGEILDI 1244
            ..:|| ..:.|||         :|.:|:.|..    .:|.|.::.:.|..||...:.:||.:.|:
  Rat   989 TQVIN-GAKNLDL---------KGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDL 1043

  Fly  1245 YSYMSVHLSEIIKDCK----------PS--CVPSPCRNGAQCKELWSSFKCVCNNPWAHIGEFCE 1297
            .:.......:|.:.|:          ||  |....|.|...|.:.|..|.|.|:.. ::.|..| 
  Rat  1044 INDALHRSGQIDRGCEVALTKADLQGPSTTCQEDSCANQGVCMQQWEGFTCDCSMT-SYSGNQC- 1106

  Fly  1298 TNINEKALTFI--------------NRESFLMRNYLSVGATPVILMHGINGERDVLKGILNQDLL 1348
               |:...|:|              |.......:.|:||.:..: ..||....|...|:      
  Rat  1107 ---NDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTV-KDGILVRIDSAPGL------ 1161

  Fly  1349 INLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLKSIQVAIV 1413
                               .:|:.|:|...: |..::|.|                  ::.::| 
  Rat  1162 -------------------GDFLQLHIEQGK-IGVVFNIG------------------TVDISI- 1187

  Fly  1414 RGEQETRMHVNE---HSVSIDR----GTLLLDEY---ANKPWSNPEKEVLS------PHRPPAPP 1462
               :|.|..||:   |.|...|    .||.:|.:   .:.|..|.:.|.|.      |.:...|.
  Rat  1188 ---KEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERLQMVKQKIPFKYNRPV 1249

  Fly  1463 TEYF--------------QFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKI-GAQLIDLADINE 1512
            .|:.              |..:||.|...|.:            |.:.||.. |.:::::|..|.
  Rat  1250 EEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQ------------GQLSGLYYDGLKVLNMAAENN 1302

  Fly  1513 RNIAPTQEGVLPNCQIKCDAE-PCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGES 1576
            .||.       .|..::...| |..:|.|.......::||...|.|:.:....:.:..:..|.:.
  Rat  1303 PNIK-------INGSVRLVGEVPSVSGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQP 1360

  Fly  1577 T---LQRKFEL-----------PGTG-----------------------RVDYVRLQLAFSSFDL 1604
            |   |....|.           |.||                       ||..:.|...|     
  Rat  1361 TSDDLVSSAECSSDDEDFVECEPSTGRSGGELVIPLLVEDPLATPPIATRVPSITLPPTF----- 1420

  Fly  1605 RRANRIMLLMQTEAERSYYLLLAITSDGYLQLEEDR------DNGQTV-----GARIDRNFLNSA 1658
               ..::.:::|..:.     |::||:..|....|:      |:|..:     |...|.|...:.
  Rat  1421 ---RPLLTIIETTKDS-----LSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTD 1477

  Fly  1659 RHSVYYVRNGTQSQLFIDREQVPLSEFAARVLTT----GG-----------DAGSNRVQIGGINS 1708
            ....|     |...|..|:.           |:|    ||           |...|:|......:
  Rat  1478 DEDFY-----TTFSLVTDKS-----------LSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTT 1526

  Fly  1709 TDS------RFAVFKSYSGCLSNIYI-QVNGHVMKPLEEYMLFTKSGADNITVINPQGVRSAQCN 1766
            |.|      ||.. .|.||.:..:.. ::|...:||..:.:|.....|                 
  Rat  1527 TTSLSPELIRFTA-SSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTA----------------- 1573

  Fly  1767 AKFDVSEQPTQEPMVNVSM---IPEPWVEEPP-ARVPYIPRFVYDENKQEDSTQVVFLTLTSVFV 1827
              :::.....:.|::...|   :|.....||. .|||.....:    ::..||..:.:.:.:...
  Rat  1574 --YELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVI----RESSSTTGMVVGIVAAAA 1632

  Fly  1828 IIVICCLLEVYRSHLAYKKRIE--RETDEDIIWSKEQATKMHESPGVKAGLLGGVTAGSGNGLPP 1890
            :.::..|..:|:    |:.|.|  .:.||    ::...:...:|.|.   |:....|.|.:|   
  Rat  1633 LCILILLYAMYK----YRNRDEGSYQVDE----TRNYISNSAQSNGT---LMKEKQASSKSG--- 1683

  Fly  1891 YTYKALPQEDKK 1902
              :|....:||:
  Rat  1684 --HKKQKNKDKE 1693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 29/143 (20%)
EGF_CA 433..476 CDD:238011 13/42 (31%)
Laminin_G_2 514..640 CDD:280389 34/147 (23%)
Laminin_G_2 698..817 CDD:280389 41/154 (27%)
EGF_CA 842..878 CDD:238011 13/35 (37%)
Laminin_G_2 1112..1240 CDD:280389 37/154 (24%)
EGF_CA 1256..1297 CDD:238011 12/52 (23%)
Laminin_G_2 1351..1503 CDD:280389 33/182 (18%)
LamG 1612..1733 CDD:304605 30/153 (20%)
Nrxn3XP_038967552.1 LamG 27..181 CDD:238058 33/150 (22%)
EGF 202..231 CDD:394967 11/30 (37%)
LamG 286..425 CDD:214598 36/152 (24%)
LamG 482..631 CDD:214598 44/159 (28%)
EGF_CA 659..692 CDD:238011 14/39 (36%)
LamG 720..854 CDD:214598 31/175 (18%)
Laminin_G_2 911..1039 CDD:396680 37/154 (24%)
LamG 1112..1291 CDD:238058 42/239 (18%)
Syndecan 1622..>1657 CDD:395821 5/38 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.