DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment axo and nrxn3

DIOPT Version :9

Sequence 1:NP_001246631.1 Gene:axo / 43923 FlyBaseID:FBgn0262870 Length:2179 Species:Drosophila melanogaster
Sequence 2:XP_031746701.1 Gene:nrxn3 / 100379902 XenbaseID:XB-GENE-956823 Length:1683 Species:Xenopus tropicalis


Alignment Length:1910 Identity:387/1910 - (20%)
Similarity:646/1910 - (33%) Gaps:598/1910 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 EISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVIVEKGQLKVVHVFGKHSTSVTVGESLNRDE 334
            ::|||.||.:..|||:|.:    |....|  .|.:.:..|.:::........|::...:.:|...
 Frog    50 DLSFQLRTNVSAGLLLYFD----DGGICD--FLCLSLADGHVQLRFSIDCAETAIVSDKKVNDGG 108

  Fly   335 WHSVMVRIDVHGARLIARVDNSQEEVYLKGLNHEYNYGVSTNLPSVVLVGGLSSEEK-----LHG 394
            ||.:|:..:.....|:...:....||..:..:        .|:.|.:.|||:.|:.:     |..
 Frog   109 WHFLMLSRNRLRTTLVLDGEAKPGEVRPQRQH--------MNIVSDLFVGGVPSDIRSGALTLGS 165

  Fly   395 VKYITESFVGCIRNV--------VLSSGKAASDLLPIAPLVATKHENVNEG-CSDMCESRHNLCF 450
            |:.:: :|.|.:.::        :|.|..|..||               || |::      |.|.
 Frog   166 VRDMS-AFAGYLLDIKYGNTEPRLLGSHGARLDL---------------EGLCTE------NPCE 208

  Fly   451 VGSRCINHYGGISCDCFGTHYEGEHC-----DI----------------YTATIITLRGASYVSY 494
            .|..|:...|..:|||..|.|.|:.|     ||                ....:.|.||:.|:.|
 Frog   209 NGGACLLLDGEPTCDCTATGYVGKFCSEDVNDIPGLAHLMIDDQGRSKAREENVATFRGSEYLCY 273

  Fly   495 RIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV 559
            .:.  ::.:.||:..|:|.|:|. ..:.|...:|:|.  .|:..::|..:|.:.::.|......:
 Frog   274 DLS--QNPIQSSSDEITLSFKTR-QRNGLILHTGKSA--DYVNLALKGGAVSLVINLGSGAFEAI 333

  Fly   560 L---TDDLTRGYWHNLTILHEQRTVSIILDQQQKVLELPATASG------NML-FDPEIYFGGGP 614
            :   .|......||.:.:....|.|:|.:|   .:|    |.:|      .|| .|...|.||.|
 Frog   334 VEPTNDKFNDNEWHEVKVTRNLRQVTISVD---GIL----TTTGYTQEDYTMLGSDDFFYVGGSP 391

  Fly   615 ELHKKKGLASHNNFVGSLKYVYYNDISILYELQR----GNPKVHYHGVLEAEF-VENEVNVIPIT 674
            ......|....|||:|.||.|.|.:..|..||.|    |:.|:..:|  :..| .||...:.||:
 Frog   392 STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYG--DVVFKCENVATLDPIS 454

  Fly   675 YPFATSHIWWP-INHAEEFNIKFDFRSSRPGAVLAYS--------DVTTSAGN--GFWEIRLTSD 728
            :....::|..| .|.....:|.||||::.|..::.::        |:.:....  .|:.:.|...
 Frog   455 FESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDG 519

  Fly   729 KLSFDLVPDVNNNVTHSTTIKINRATS-------WHSVEL--DYKLGEIR-------FTVDYRHT 777
            .|.  |:.|:.     |.|||: :||:       |..|::  |.:.|.|.       ||......
 Frog   520 HLY--LLLDMG-----SGTIKV-KATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESE 576

  Fly   778 L----SQMY--GLTFNIGDKLIIGSSLKSAAM--GLVGCIRDIEINGHLIEPRHVVKTERVVGEV 834
            :    ..||  ||..|... ||:.:.|.:|.:  |.||||||:.|:|.....|.:.:.:...|  
 Frog   577 ILDLEGDMYLGGLPENRAG-LILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNAAG-- 638

  Fly   835 ALDNCNYID-------PCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELAL 892
            ...:|:.:.       |||....|..|...||      |||..||:.|:.|.        .|.::
 Frog   639 VKSSCSRLSGKQCDSYPCKNNAACRDGWNRFV------CDCTGTGHWGRTCE--------REASI 689

  Fly   893 LGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYRE 957
            |.:          || |::            ......:|.|.....|.:|...:..:...:    
 Frog   690 LSY----------DG-GMY------------MKIIMPVVMHTEAEDVSLRFKSQRAYGLLV---- 727

  Fly   958 FSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSSAKNLTVDFLGNVKRGACPCSVNKTC 1022
                                             ||....||..|.::..|    |.....||..|
 Frog   728 ---------------------------------ATTSRDSADTLRLELDG----GKVKLMVNLDC 755

  Fly  1023 VDPNQSCNCD-----------VKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRIT--- 1073
            :..|  ||..           :.:|:|::.. ..:..::|.:|       .| ||.|:|.:.   
 Frog   756 IRIN--CNSSKGPETLYAGQKLNDNEWHTVR-VVRRGKTLKLT-------VD-DDVAEGTMVGDH 809

  Fly  1074 --------------------------LGPLECVETNTQKYV------------------------ 1088
                                      :|.|:.:..|...|:                        
 Frog   810 TRLEFHNIETGFMTEKRFASAVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIA 874

  Fly  1089 --VTFTTSQSYI---EVPGWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQ----- 1143
              |||.|..||:   .:..:....:.|.|:|......:||.              :||..     
 Frog   875 DPVTFRTKASYLTLSTLQAYTSMHLFFQFKTISPDGFILFN--------------SGDGNDFIAV 925

  Fly  1144 ------LTFTFTLSTGTTRELVI--NSHRRLNGGEWHKIWI--DYNQYH--------VRFMINTD 1190
                  :.:.|.|..|..   ||  ||.|.||..:||.:.|  |.:..|        |..:|| .
 Frog   926 ELVKGYIHYVFDLGNGPN---VIKGNSERPLNDNQWHNVVITRDNSNTHTLKVDTKAVTQVIN-G 986

  Fly  1191 YQMLDLLPEEEFGPFEGSMYIGG---ATFDLLKKL-SVKAGLIGCFRGLVVNGEILDIYSYMSVH 1251
            .:.|||         :|.:||.|   :.:..|.|| :.:.|..||...:.:||.:.|:.......
 Frog   987 AKNLDL---------KGELYIAGLVQSMYSTLPKLVASRDGFQGCLASVDLNGRLPDLIGDALHR 1042

  Fly  1252 LSEIIKDCK------------PSCVPSPCRNGAQCKELWSSFKC----------VCNNP------ 1288
            ..:|.:.|:            .:|....|.|...|.:.|..|.|          .||:|      
 Frog  1043 SGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNHCNDPGATYIF 1107

  Fly  1289 ----------WAHIGEFCETNINEKALTFIN--RESFLMRNYLSVGATPVILMHGINGERDVLKG 1341
                      |.| .:...|..:..|:.|..  :|..|:|...:.|....:.:|.:.|:..|...
 Frog  1108 GKSGGLILYTWPH-NDRPSTRTDRLAVGFSTTVKEGILVRIDSAPGLMDYLQLHIVQGKIGVTFN 1171

  Fly  1342 ILNQDLLINLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLK 1406
            |.:||:.|...:...|          :...|:       :.:..|.|    |.||          
 Frog  1172 IGSQDISIREESAPVN----------DGKYHV-------VKYTRNGG----NATL---------- 1205

  Fly  1407 SIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWS---NPEKEVLSPHRPPAPPTEYFQF 1468
                      |.....||||   ...|...|.:....|:.   .||.......||........|.
 Frog  1206 ----------QVDNWPVNEH---YPGGNTELHQKPKLPFKISRTPEDGQQDKGRPLTIFNTQAQI 1257

  Fly  1469 HVGGYDPANLLRPNVDAPALEGYIGCVRGLKI-GAQLIDLADINERNI-----------APTQEG 1521
            .:||.|..   ||         :.|.:.||.. |.:::::|.....||           .|:..|
 Frog  1258 AIGGMDRG---RP---------FQGQLSGLYYNGLKVLNMAAEPNPNINISGSVRLVGEVPSIHG 1310

  Fly  1522 VLPNCQIKCDAEPC--------------KN----GGTCQEHFAEQLSTCDCEHTSFLGEFCSEEK 1568
            ..|...:..:....              ||    |.|..:...   |:.:|..:|...:....:.
 Frog  1311 TTPTTSMPPEMSTTIMETTTTLATTTTRKNRSSPGSTLTDDIG---SSAECFISSDDEDVTDCDT 1372

  Fly  1569 GADFSGES-----TLQRKFELPGTG-RVDYVRLQLAFSSFDLRRANRIMLLMQTEAERSYYLLLA 1627
            |...||:.     .::...::|... |...:.|...|..        ::.:::|..:..     :
 Frog  1373 GTGTSGDELVIPVLVEDPLDIPSVATRAPSITLPPTFQP--------LLTIIETTKDSQ-----S 1424

  Fly  1628 IT------------SDGYLQLEEDRDNGQTV-----GARIDRNFLNSARHSVY----YVRNGTQS 1671
            :|            |||.     |.|:|..:     |...|.|...:.....|    .|.:.:.|
 Frog  1425 VTPEEGLPCLSDQGSDGC-----DDDDGLVISGYGSGETFDSNLPPTDDEDFYTTLSLVTDKSLS 1484

  Fly  1672 QLFID---REQVPLSEFAARVLTTGGDAGSNRVQIGGINSTDSRFAVFK---SYSGCLSNIYIQV 1730
            ..|.|   :.|.|  ::.::      |...|:|...|..||.|.....|   |.||.:..:....
 Frog  1485 TSFFDGGFKSQAP--KWGSK------DFKPNKVSEPGRTSTTSLPPELKRSTSSSGMVPMVPAGK 1541

  Fly  1731 NGHVMKPLEEYMLFTKSGADNITVINPQGVRSAQCNAKFDVSEQPTQEPMVNVSMIPEPWVEEP- 1794
            ..|.:||..:.:|.:...|                   :::.....:.|::...|........| 
 Frog  1542 MNHELKPQPDIVLLSLPTA-------------------YELDSTKLRSPLITSPMFRNVPTANPT 1587

  Fly  1795 ---PARVPYIPRFVYDENKQEDSTQVVFLTLTSVFVIIVICCLLEVYRSHLAYKKRIE--RETDE 1854
               ..|||.....|    ::..||..:.:.:.:...:.::..|..:|:    |:.|.|  .:.||
 Frog  1588 MPGSRRVPGASEVV----RESSSTTGMVVGIVAAAALCILILLYAMYK----YRNRDEGSYQVDE 1644

  Fly  1855 --DIIWSKEQAT------KMHESPG 1871
              :.|.:..|:.      |.|.|.|
 Frog  1645 TRNYITNSAQSNGALMKEKQHSSKG 1669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
axoNP_001246631.1 KU 119..171 CDD:238057
Laminin_G_2 275..411 CDD:280389 28/148 (19%)
EGF_CA 433..476 CDD:238011 14/43 (33%)
Laminin_G_2 514..640 CDD:280389 35/135 (26%)
Laminin_G_2 698..817 CDD:280389 39/152 (26%)
EGF_CA 842..878 CDD:238011 13/42 (31%)
Laminin_G_2 1112..1240 CDD:280389 38/154 (25%)
EGF_CA 1256..1297 CDD:238011 13/78 (17%)
Laminin_G_2 1351..1503 CDD:280389 29/155 (19%)
LamG 1612..1733 CDD:304605 29/147 (20%)
nrxn3XP_031746701.1 LamG 27..181 CDD:238058 31/145 (21%)
EGF 202..233 CDD:394967 12/36 (33%)
LamG 286..417 CDD:214598 37/140 (26%)
LamG 474..623 CDD:214598 42/157 (27%)
EGF_CA 651..684 CDD:238011 13/38 (34%)
LamG 712..846 CDD:214598 26/185 (14%)
Laminin_G_2 903..1031 CDD:396680 38/154 (25%)
LamG 1130..1279 CDD:214598 41/204 (20%)
Syndecan 1609..>1644 CDD:395821 5/38 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11164
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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