DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment axo and cntnap1

DIOPT Version :9

Sequence 1:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster
Sequence 2:	NP_001090759.1	Gene:	cntnap1 / 100037844	XenbaseID:	XB-GENE-963972	Length:	1326	Species:	Xenopus tropicalis

Alignment Length:	1170	Identity:	272/1170 - (23%)
Similarity:	455/1170 - (38%)	Gaps:	231/1170 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 GISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTR-RISLMFRTNFDDSALF 524
            |:....||..|..:        :::..|....||::   |.::..:.. .||..|:|...:..|.
Frog   167 GLRVGLFGCPYRHD--------VLSFDGDDLFSYKL---KGKISRTLNDSISFNFKTLEKNGMLM 220

  Fly   525 YASGESLKHQYIAASIKNQSVHVEMDFGDNVMSTV----------LTDDLTRGYWHNLTILHEQR 579
            :|.|.  :..||...::...:..:|..|::.:..|          |.||   .:||::.|..:.|
Frog   221 HAEGS--QGDYITLELQKARLIFQMSLGNSPIHPVDSHTVVKLGSLLDD---QHWHSVYIERQGR 280

  Fly   580 TVSIILDQQQKVLELPATASGNML-FDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISIL 643
            .::|.||.:  .:.:......:.| .|.||:|.|  .::::|.|:...||.|.|:.:.:|.|:|.
Frog   281 DLNITLDGE--TIRVKCKGDFDQLDLDTEIFFAG--IVYQEKSLSHKQNFRGCLENILFNGINIA 341

  Fly   644 YELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWWP-INHAEEFNIKFDFRSSRPGAVL 707
            ...:|....:.:.|  :..|...|:..:|:|:....:::..| :..:.:..:.|.||:.....:|
Frog   342 DLARRKKSSIAFVG--KVRFSCIEMPYVPVTFSGINNYLLVPGVPASPKMMVSFKFRTWDTVGLL 404

  Fly   708 AYSDVTTSAGNGFWEIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATSWHSVEL----------- 761
            .||..|.|.|:  .|:.|:..:::..:.......:..:...::|.. .||||.|
Frog   405 LYSSFTGSLGS--LEMALSEGQINVSISQPGMKKLVFAAGYRLNDG-FWHSVSLVARENSAVVII 466

  Fly   762 DYKLGEIRFTVDYRHTLSQMYGLTFNIG--DKLIIGSSLKSAAMGLVGCIRDIEINGHLIEPRHV 824
            |...| ..|.|:|...:..  |.|:..|  .|...||...|......||::.|.::|   :|
Frog   467 DEDEG-AEFKVNYDFQVGT--GDTYYFGGCPKPAAGSGCYSNQTAFHGCMQMINVDG---QP--- 522

  Fly   825 VKTERV-------VGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTK 882
            |...|:       ..||..:.|...|.| |||.|||||:|:...|...|.|..|||.|:.||.:.
Frog   523 VDLHRMQLGLFGRFSEVMFNVCAIADRC-RPNPCEHGGRCYQSWDDFFCICDMTGYKGETCHKSL 586

  Fly   883 YRKTCEELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVR-SARE 946
            :::.|:...:.| ..|..|.||.||:|...|.:|.||..  |....|||.|:......|. |:.:
Frog   587 FKENCDAYRVSG-KYSGNYTIDPDGSGPMKPFYVHCDIS--EERAWTIVHHDRYYATRVTGSSPD 648

  Fly   947 SDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL-----ELHSATWFTSSAKNLTVDFL 1006
            ..|...:.|...:...:..|.:.|.||.|.|::.|||::|     .|..:.|.  ...|....:.
Frog   649 QPFLGEVNYWNATWGEVSALANGSEYCEQRIEFSCYRSRLLNTPNGLPYSFWM--GRNNERHFYW 711

  Fly  1007 GNVKRG--ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQ 1069
            |....|  .|.|.::|:|.||...||||....:|..|:|..:....|.:|.:..........||.
Frog   712 GGSSPGIQRCGCGIDKSCADPKLFCNCDGDYTQWKYDKGLLKFRDHLPVTRVVVGDTNRTGSEAW 776

  Fly  1070 GRITLGPLECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAFSFRTTGEKAILLFQP------ 1125
              .::|||.|.........|||....|.: .|.::..   ||:|.|:||......|...
Frog   777 --FSVGPLRCYGDRNTWNTVTFMKGASLL-FPTFKPDTSIDISFYFKTTARSGTFLETSGNRCGF 838

  Fly  1126 PIRP----HYPSF------------MVALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKI 1174
            |:|.    .|.:|            .:.|....:|.|.:.:..| ...:.:.|..:.|..|||::
Frog   839 PLRHTWDLRYETFWMDMWYRCRNFIRIELNSTTELAFIYDIGNG-FENVTVKSPFKFNDNEWHQV 902

  Fly  1175 WIDYNQYHVRFMINTDYQMLDLLP--EEEFG-------PFEGSMYIGGATFDLLKKLSVKAGLIG 1230
            ..:.|....|..:       ||||  ..:|.       .::..:|:|.|...|       ...:|
Frog   903 KAEMNVKLARLKV-------DLLPWSIRKFPLQTYLNMTYDQPLYVGTAEHKL-------KPFLG 953

  Fly  1231 CFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSCVPSP---CRNGAQCKELWSSFKCVCNNPWAHI 1292
            |.|.|.:||..||:....:..|. :..:|...| ..|   |:||.:|.|.:|.:.|.||.. ...
Frog   954 CLRALRMNGVTLDLEGKANETLG-LRTNCTGYC-EKPRLECQNGGRCVERYSHYTCDCNGT-GFE 1015

  Fly  1293 GEFCETNINE--KALTFINRESFL------MRNYLSVGATPVILMHGINGERDVLKGILNQDLLI 1349
            |.||..:|..  :|.|:: |.|.|      .:.:.:|...|:.           :..:..:::..
Frog  1016 GPFCTRDIGAYFEAGTWV-RHSILSAAMVAAQEFANVAYLPLF-----------VSNLTREEISF 1068

  Fly  1350 NLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDEIVNLTLLDDTLMASLK-SIQVAIV 1413
            :.||..:.|::||.:...::::.:                    |...|.||..:.| .|...:.
Frog  1069 SFRTTTSPAVLLYVSSFSSDYIAV--------------------LVRPDGTLQLNYKVGITPYVY 1113

  Fly  1414 RGEQETRMHVNEHSVSIDRGTLLL----DEYANKPWSNPEKEVLSPHRPPAPPTEYFQF------ 1468
            :..:........|.|:|.|..|.|    |.|                     |.|..||
Frog  1114 QLNKRNMTDGRPHRVNITRENLTLYTQVDFY---------------------PLEKNQFYLWEDR 1157

  Fly  1469 --------HVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPN 1525
                    ::|......::...|......|:.||            |||:...||.|.::...|:
Frog  1158 KFDTPKALYLGRVVEIGIIDSEVQKFNTPGFTGC------------LADVRFNNITPVRDIFRPS 1210

Fly 1526 1525
Frog 1211 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axo	NP_001246631.1	KU	119..171	CDD:238057
		Laminin_G_2	275..411	CDD:280389
		EGF_CA	433..476	CDD:238011	4/14 (29%)
		Laminin_G_2	514..640	CDD:280389	33/136 (24%)
		Laminin_G_2	698..817	CDD:280389	31/131 (24%)
		EGF_CA	842..878	CDD:238011	18/35 (51%)
		Laminin_G_2	1112..1240	CDD:280389	33/158 (21%)
		EGF_CA	1256..1297	CDD:238011	14/43 (33%)
		Laminin_G_2	1351..1503	CDD:280389	28/170 (16%)
		LamG	1612..1733	CDD:304605
cntnap1	NP_001090759.1	FA58C	46..174	CDD:238014	1/6 (17%)
		LamG	205..337	CDD:214598	34/140 (24%)
		LamG	368..519	CDD:238058	35/156 (22%)
		EGF	550..581	CDD:333761	17/31 (55%)
		LamG	793..961	CDD:238058	40/183 (22%)
		EGF_CA	<992..1020	CDD:238011	11/28 (39%)
		LamG	1054..1198	CDD:238058	32/207 (15%)
		4.1m	1281..1298	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171014at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920