Protein Alignment Rok and HSL1

DIOPT Version :9

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_012821.2
• Gene: HSL1 / 853760
• SGDID: S000001584
• Length: 1518
• Species: Saccharomyces cerevisiae
• Alignment Length: 1599
• Identity: 292/1599 - (18%)
• Similarity: 555/1599 - (34%)
• Gaps: 432/1599 - (27%)

  Fly     1 MPAGRETVTKQRS-------MDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLR 58
            :|.||.:...:::       ::...:|.:..|||.::   |:.:....|....:.||.....|.|
Yeast    11 VPKGRPSSLAKKAAKRAMAKVNSNPKRASGHLERVVQ---SVNDATKRLSQPDSTVSVATKSSKR 72

  Fly    59 RLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEM 123
            :.::                    .|..:...|.:|.|:.|.|:|.::..:.|:.|:|.:.|.:.
Yeast    73 KSRD--------------------TVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKA 117

  Fly   124 ----------------------MKRPDSAFFWEERH----------------IMAHANSEWIVQL 150
                                  :..|..|......|                :::|.|   ::.|
Yeast   118 FVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLISHTN---VMAL 179

  Fly   151 HFAFQDAKYLYMVMDFMPGGDIVS-LMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDN 214
            ...:::...||:|::::.||::.. |:....:||:.||.|..::|..:...|:....|||:||:|
Yeast   180 FEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPEN 244

  Fly   215 MLLDSYG-HLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIF 278
            :|||... .:|:||||.......|..:.:|  .|:|.|.|||::..:..   :|...|.||.||.
Yeast   245 LLLDKKNRRIKIADFGMAALELPNKLLKTS--CGSPHYASPEIVMGRPY---HGGPSDVWSCGIV 304

  Fly   279 LYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDI 343
            |:.:|.|..||..|::.....|:...|..:   |. .:|.:|:.||...|....::  |...::|
Yeast   305 LFALLTGHLPFNDDNIKKLLLKVQSGKYQM---PS-NLSSEARDLISKILVIDPEK--RITTQEI 363

  Fly   344 KAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIE----RDEKPEEVFPVPKG-FDGNHL 403
            ..||..:    .:|::  .|..|:.::..|:..|...:.:    .:..|..|....|| .|.:.|
Yeast   364 LKHPLIK----KYDDL--PVNKVLRKMRKDNMARGKSNSDLHLLNNVSPSIVTLHSKGEIDESIL 422

  Fly   404 PFIGFTYTG--------------------DYQL-----------LSSDTVDAES------KEANV 431
            ..:...:.|                    .|.|           |||.:.:.:|      .|..:
Yeast   423 RSLQILWHGVSRELITAKLLQKPMSEEKLFYSLLLQYKQRHSISLSSSSENKKSATESSVNEPRI 487

  Fly   432 ANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQ 496
            ..:...:||.|       ..|.:|::|.|.:|         .:..:|.....|...||....|:
Yeast   488 EYASKTANNTG-------LRSENNDVKTLHSL---------EIHSEDTSTVNQNNAITGVNTEI- 535

  Fly   497 RIASEYEKDLALRQHNYKVAMQKVEQEIEL-------RKKTEALLVETQRNLENEQKTRARDLNI 554
                           |..|..||.:..|..       :.:.||:.:.....:.|...:|.
Yeast   536 ---------------NAPVLAQKSQFSINTLSQPESDKAEAEAVTLPPAIPIFNASSSRI----- 580

  Fly   555 NDKVVSLEKQLLEMEQSYKT-ETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTLQK------ 612
                         ...||.: .:.:.:.|:..|:.|..:..:..|.|.|....:..|.|
Yeast   581 -------------FRNSYTSISSRSRRSLRLSNSRLSLSASTSRETVHDNEMPLPQLPKSPSRYS 632

  Fly   613 ---------------HKEELGQENAELQALVVQEKNLRS--------QLKEMHKEAENKMQTLIN 654
                           || .|.::|  :.|.|...:.|::        .|:.:.|.:.|....|:.
Yeast   633 LSRRAIHASPSTKSIHK-SLSRKN--IAATVAARRTLQNSASKRSLYSLQSISKRSLNLNDLLVF 694

  Fly   655 DIERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEA 719
            | :....::..::..|:      |:.....:..|||:...|..:...:        .|::..||.
Yeast   695 D-DPLPSKKPASENVNK------SEPHSLESDSDFEILCDQILFGNAL--------DRILEEEED 744

  Fly   720 NLQEVKALQSKLNEEKSA----RIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQES--- 777
            |.:|....:.:.|:.||:    .|.....::|.|.......::..|..:..:..|......|
Yeast   745 NEKERDTQRQRQNDTKSSADTFTISGVSTNKENEGPEYPTKIEKNQFNMSYKPSENMSGLSSFPI 809

  Fly   778 -EKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKS 841
             ||...|.|...:|...:.|.||:::...:::    :::..::.|...|||..::..:..:.||.
Yeast   810 FEKENTLSSSYLEEQKPKRAALSDITNSFNKM----NKQEGMRIEKKIQREQLQKKNDRPSPLKP 870

  Fly   842 THHEALANNR------ELQAQLEAEQCFSRLYKT------QANENREESA-----ER--LSKIED 887
            ..|:.|..|.      :....|:..:..|:...:      |..:.::|.|     ||  |...|.
Yeast   871 IQHQELRVNSLPNDQGKPSLSLDPRRNISQPVNSKVESLLQGLKFKKEPASHWTHERGSLFMSEH 935

  Fly   888 LEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELK--------DFVMKHRNE 944
            :|:|:......|.:..:......:|.|..:.:|  |.:..||::..|.        ....|:.::
Yeast   936 VEDEKPVKASDVSIESSYVPLTTVATSSRDPSV--LAESSTIQKPMLSLPSSFLNTSMTFKNLSQ 998

  Fly   945 INAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALM--------------RSSKD 995
            |.|.:.         ::.|..:.|..:....:....:||..:::|.              :.|..
Yeast   999 ILADDG---------DDKHLSVPQNQSRSVAMSHPLRKQSAKISLTPRSNLNANLSVKRNQGSPG 1054

  Fly   996 EEITKLLDKCKNEVLLKQVAVNKL-AEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQ 1059
            ..::..||...:.....::..|.. |:.:...::|....|......|....|||.::.... :|:
Yeast  1055 SYLSNDLDGISDMTFAMEIPTNTFTAQAIQLMNNDTDNNKINTSPKASSFTKEKVIKSAAY-ISK 1118

  Fly  1060 ERDKFNQLLLKHQDLQQLCAEEQQLKQKMVME-IDCKATEIENLQSKLNETASL--SSADNDPED 1121
            |::..|             ::...:....:.. .|.||..|  .:...::..||  ||:::|...
Yeast  1119 EKEPDN-------------SDTNYIPDYTIPNTYDEKAINI--FEDAPSDEGSLNTSSSESDSRA 1168

  Fly  1122 SQHSSLLSL--------------------------------TQDSVFEGWLSVPNKQNRR----- 1149
            |.|...:|:                                |::.:.:..||..|..|..
Yeast  1169 SVHRKAVSIDTMATTNVLTPATNVRVSLYWNNNSSGIPRETTEEILSKLRLSPENPSNTHMQKRF 1233

  Fly  1150 ---RGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPR 1211
               ||........|..|.:.:|.:.:.|:...|....||:.|..|..|..::..|   :.|:  |
Yeast  1234 SSTRGSRDSNALGISQSLQSMFKDLEEDQDGHTSQADILESSMSYSKRRPSEESV---NPKQ--R 1293

  Fly  1212 IFQLLYAGEGASHR-----------------PDEQSQLDVSVL----HGNCNEERPGTIVHKGHE 1255
            :..|....|..|.:                 .:|.|||.:.|:    :.|..|.....|
Yeast  1294 VTMLFDEEEEESKKVGGGKIKEEHTKLDNKISEESSQLVLPVVEKKENANNTENNYSKI------ 1352

  Fly  1256 FVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDML 1320
                           |||.........|.|...      :.|..|  |:.        :|.:::.
Yeast  1353 ---------------PKPSTIKVTKDTAMESNT------QTHTKK--PIL--------KSVQNVE 1386

  Fly  1321 LLAATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGSK 1359
            :..|...|:..|..:|.:..        |.:||:|..||
Yeast  1387 VEEAPSSDKKNWFVKLFQNF--------SSHNNATKASK 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	87/394 (22%)
		S_TKc	87..349	CDD:214567	75/301 (25%)
		SbcC	484..1088	CDD:223496	113/690 (16%)
		Rho_Binding	963..1027	CDD:286056	10/78 (13%)
		PH_ROCK	1134..1250	CDD:269948	29/144 (20%)
		C1	1254..1307	CDD:197519	8/52 (15%)
HSL1	NP_012821.2	STKc_BRSK1_2	79..369	CDD:270983	75/303 (25%)
		AMPKA_C_like	1347..1517	CDD:418410	20/116 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000