Protein Alignment Rok and CDC42BPA

DIOPT Version :10

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_001374479.1
• Gene: CDC42BPA / 8476
• HGNCID: 1737
• Length: 1845
• Species: Homo sapiens
• Alignment Length: 1502
• Identity: 423/1502 - (28%)
• Similarity: 688/1502 - (45%)
• Gaps: 288/1502 - (19%)

  Fly    21 RANTLEREMRDPTSICNVDC-----LLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQL 80
            |...||:.:.|..:..|..|     |||.:..|..:|::..|||.|||.:|....||...::.|:
Human     6 RLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQM 70

  Fly    81 RMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSE 145
            |::.|||..:|:||.||||||.:|:.|::.:|:|||.|:|:||:||.::|.|.|||.::.:.:::
Human    71 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNK 135

  Fly   146 WIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHR 208
            ||..||:||||...||:|||:..|||:::|:..::  :||..|.||..|:|:|:|::|.:.:|||
Human   136 WITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHR 200

  Fly   209 DVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS-QGVDNEYGRECDW 272
            |:||||:|:|..||::|||||:|:::..:|.|.||.|||||||||||:||: :.....||.||||
Human   201 DIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDW 265

  Fly   273 WSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLG 336
            ||:|:.:||||:|||||||:|||.||||||:||....||.:| ::||.||.|||..:..|..|||
Human   266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLG 330

  Fly   337 RYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD-EKPEEVFPVP--KGF 398
            :.||||.|.||||....|  ||||....|.:||:||..||.|| |::.| .|..|..|.|  ..|
Human   331 QNGIEDFKKHPFFSGIDW--DNIRNCEAPYIPEVSSPTDTSNF-DVDDDCLKNSETMPPPTHTAF 392

  Fly   399 DGNHLPFIGFTYTGDYQLLSSD------TVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNEL 457
            .|:||||:|||||....|  ||      |....|.:.:|.......||..       ..:....:
Human   393 SGHHLPFVGFTYTSSCVL--SDRSCLRVTAGPTSLDLDVNVQRTLDNNLA-------TEAYERRI 448

  Fly   458 KRLE-ALLERERGRSEALEQQDA-------------------GLRQQIELITKREAELQRIASEY 502
            |||| ..||..|...|:.:...|                   .|:::||.:.|:..|...:..:.
Human   449 KRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQL 513

  Fly   503 EKDLALRQH---------NYKVAMQKVEQEIE-LRKKTEALLVETQRNLENEQKTRARDLNINDK 557
            |:..|:||.         .|:..::.::||.| |.|:    ||:....|:|:.| ..:|.:...|
Human   514 EEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKE----LVQASERLKNQSK-ELKDAHCQRK 573

  Fly   558 VVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTL-------QKHKE 615
            :..  ::.:|:.:.........|||.:|       |:.:||:|..::..:::|       ::.|:
Human   574 LAM--QEFMEINERLTELHTQKQKLARH-------VRDKEEEVDLVMQKVESLRQELRRTERAKK 629

  Fly   616 ELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLIN---DIERTMCREQKAQEDNRALLEKI 677
            ||......|.|...:::.||.|.:...|:.||:::.|..   .....:|..:..||     :.|:
Human   630 ELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQE-----ITKL 689

  Fly   678 -SDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANL---QEVKALQSKLNEEKSAR 738
             :||||.....:.||...:|.:..|:|    ..|..|...|...|   :|:..|:.||
Human   690 KTDLEKKSIFYEEELSKREGIHANEIK----NLKKELHDSEGQQLALNKEIMILKDKL------- 743

  Fly   739 IKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAAL----QSQLDQEHSKRNALLS 799
                    ||.|         |:.|...::.|.|.:|:.|:...|    ..:|..|..|...|..
Human   744 --------EKTR---------RESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYE 791

  Fly   800 ELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQL---------KSTHHEALANNRELQA 855
            .||:|:.::      |.:: |:|:.::|:...:|..:|::         ...:.:|||:  ::..
Human   792 NLSIHNQQL------EEEV-KDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALAS--KMTE 847

  Fly   856 QLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETV 920
            :|||.:..|  ..|:|.: ......|.:|::      :|.:.::|.|:   |:|..|:...:|.:
Human   848 ELEALRNSS--LGTRATD-MPWKMRRFAKLD------MSARLELQSAL---DAEIRAKQAIQEEL 900

  Fly   921 ADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQE 985
            ..::....|.|.:|||...|:...::..|..:...:|..:|       |..|::|      .|..
Human   901 NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSE-------KGIEHQD------SQHS 952

  Fly   986 ELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVM-NRRDSDLPKQKNK------------- 1036
            .||.:.:..|     .||:.::..   ..:.:.|.:.: :|..|..|..|.:
Human   953 FLAFLNTPTD-----ALDQFEDSF---SSSSSSLIDFLDDRSPSCTPASKGRRTDPVENTYVWNP 1009

  Fly  1037 -------ARSTAELRKKEKEMRRL--QQELS-----------------QERDKFNQLLLK----- 1070
                   :|||:.....|.|..:.  ...||                 ..:.|.:|..:|
Human  1010 SVKFHIQSRSTSPSTSSEAEPVKTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTP 1074

  Fly  1071 ---HQD-------LQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQHS 1125
               ||.       ::|.|:.|       |....|..|.:    :|...|..:     .||  |..
Human  1075 TKCHQCTSLMVGLIRQGCSCE-------VCGFSCHITCV----NKAPTTCPV-----PPE--QTK 1121

  Fly  1126 SLLSLTQD----SVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVL--I 1184
            ..|.:...    :.:||.:.:|.....::  ||:|...||...|:..|:....|.:....|:  :
Human  1122 GPLGIDPQKGIGTAYEGHVRIPKPAGVKK--GWQRALAIVCDFKLFLYDIAEGKASQPSVVISQV 1184

  Fly  1185 LDL-SKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERP-- 1246
            :|: .:.:.|.||...|||.|..|:||.||::.     ||......::..:.:|....||:..
Human  1185 IDMRDEEFSVSSVLASDVIHASRKDIPCIFRVT-----ASQLSASNNKCSILMLADTENEKNKWV 1244

  Fly  1247 GTI-----VHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRC----RNKIHKEHVDKHD 1302
            |.:     :.|.::|...:.::|........||....:..|..:.:|.    ...:...||.|.:
Human  1245 GVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDE 1309

  Fly  1303 PLAPCKLNHDPRSARDMLLLAATPEDQSLWV-------ARLLKRIQKSGYKAASYNNNSTDGSKI 1360
            .:..    .|.:....:.|:   |.||.:.|       .||.......|.:...|..:.|.|.:.
Human  1310 IIRV----GDNKKIHQIELI---PNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQT 1367

  Fly  1361 SPSQSTR 1367
            ..|...|
Human  1368 VTSGKVR 1374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	182/356 (51%)
		Smc	527..>1121	CDD:440809	136/675 (20%)
		ROCK_SBD	849..920	CDD:409019	15/70 (21%)
		PH_ROCK	1134..1250	CDD:269948	31/125 (25%)
		C1_ROCK	1247..1310	CDD:410363	11/71 (15%)
CDC42BPA	NP_001374479.1	STKc_MRCK_alpha	4..412	CDD:270773	199/410 (49%)
		Mplasa_alph_rch	<442..954	CDD:275316	128/592 (22%)
		KELK	529..608	CDD:464876	21/92 (23%)
		DMPK_coil	881..941	CDD:117396	14/62 (23%)
		C1_MRCKalpha	1062..1121	CDD:410414	16/76 (21%)
		PH_MRCK	1123..1257	CDD:269949	33/140 (24%)
		CNH	1288..1546	CDD:459938	18/94 (19%)