DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rok and CDC42BPA

DIOPT Version :9

Sequence 1:NP_536796.2 Gene:Rok / 43916 FlyBaseID:FBgn0026181 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_001374479.1 Gene:CDC42BPA / 8476 HGNCID:1737 Length:1845 Species:Homo sapiens


Alignment Length:1502 Identity:423/1502 - (28%)
Similarity:688/1502 - (45%) Gaps:288/1502 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RANTLEREMRDPTSICNVDC-----LLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQL 80
            |...||:.:.|..:..|..|     |||.:..|..:|::..|||.|||.:|....||...::.|:
Human     6 RLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQM 70

  Fly    81 RMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSE 145
            |::.|||..:|:||.||||||.:|:.|::.:|:|||.|:|:||:||.::|.|.|||.::.:.:::
Human    71 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNK 135

  Fly   146 WIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHR 208
            ||..||:||||...||:|||:..|||:::|:..::  :||..|.||..|:|:|:|::|.:.:|||
Human   136 WITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHR 200

  Fly   209 DVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS-QGVDNEYGRECDW 272
            |:||||:|:|..||::|||||:|:::..:|.|.||.|||||||||||:||: :.....||.||||
Human   201 DIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDW 265

  Fly   273 WSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLG 336
            ||:|:.:||||:|||||||:|||.||||||:||....||.:| ::||.||.|||..:..|..|||
Human   266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLG 330

  Fly   337 RYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD-EKPEEVFPVP--KGF 398
            :.||||.|.||||....|  ||||....|.:||:||..||.|| |::.| .|..|..|.|  ..|
Human   331 QNGIEDFKKHPFFSGIDW--DNIRNCEAPYIPEVSSPTDTSNF-DVDDDCLKNSETMPPPTHTAF 392

  Fly   399 DGNHLPFIGFTYTGDYQLLSSD------TVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNEL 457
            .|:||||:|||||....|  ||      |....|.:.:|.......||..       ..:....:
Human   393 SGHHLPFVGFTYTSSCVL--SDRSCLRVTAGPTSLDLDVNVQRTLDNNLA-------TEAYERRI 448

  Fly   458 KRLE-ALLERERGRSEALEQQDA-------------------GLRQQIELITKREAELQRIASEY 502
            |||| ..||..|...|:.:...|                   .|:::||.:.|:..|...:..:.
Human   449 KRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQL 513

  Fly   503 EKDLALRQH---------NYKVAMQKVEQEIE-LRKKTEALLVETQRNLENEQKTRARDLNINDK 557
            |:..|:||.         .|:..::.::||.| |.|:    ||:....|:|:.| ..:|.:...|
Human   514 EEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKE----LVQASERLKNQSK-ELKDAHCQRK 573

  Fly   558 VVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTL-------QKHKE 615
            :..  ::.:|:.:.........|||.:|       |:.:||:|..::..:::|       ::.|:
Human   574 LAM--QEFMEINERLTELHTQKQKLARH-------VRDKEEEVDLVMQKVESLRQELRRTERAKK 629

  Fly   616 ELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLIN---DIERTMCREQKAQEDNRALLEKI 677
            ||......|.|...:::.||.|.:...|:.||:::.|..   .....:|..:..||     :.|:
Human   630 ELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQE-----ITKL 689

  Fly   678 -SDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANL---QEVKALQSKLNEEKSAR 738
             :||||.....:.||...:|.:..|:|    ..|..|...|...|   :|:..|:.||       
Human   690 KTDLEKKSIFYEEELSKREGIHANEIK----NLKKELHDSEGQQLALNKEIMILKDKL------- 743

  Fly   739 IKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAAL----QSQLDQEHSKRNALLS 799
                    ||.|         |:.|...::.|.|.:|:.|:...|    ..:|..|..|...|..
Human   744 --------EKTR---------RESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYE 791

  Fly   800 ELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQL---------KSTHHEALANNRELQA 855
            .||:|:.::      |.:: |:|:.::|:...:|..:|::         ...:.:|||:  ::..
Human   792 NLSIHNQQL------EEEV-KDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALAS--KMTE 847

  Fly   856 QLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETV 920
            :|||.:..|  ..|:|.: ......|.:|::      :|.:.::|.|:   |:|..|:...:|.:
Human   848 ELEALRNSS--LGTRATD-MPWKMRRFAKLD------MSARLELQSAL---DAEIRAKQAIQEEL 900

  Fly   921 ADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQE 985
            ..::....|.|.:|||...|:...::..|..:...:|..:|       |..|::|      .|..
Human   901 NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSE-------KGIEHQD------SQHS 952

  Fly   986 ELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVM-NRRDSDLPKQKNK------------- 1036
            .||.:.:..|     .||:.::..   ..:.:.|.:.: :|..|..|..|.:             
Human   953 FLAFLNTPTD-----ALDQFEDSF---SSSSSSLIDFLDDRSPSCTPASKGRRTDPVENTYVWNP 1009

  Fly  1037 -------ARSTAELRKKEKEMRRL--QQELS-----------------QERDKFNQLLLK----- 1070
                   :|||:.....|.|..:.  ...||                 ..:.|.:|..:|     
Human  1010 SVKFHIQSRSTSPSTSSEAEPVKTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTP 1074

  Fly  1071 ---HQD-------LQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQHS 1125
               ||.       ::|.|:.|       |....|..|.:    :|...|..:     .||  |..
Human  1075 TKCHQCTSLMVGLIRQGCSCE-------VCGFSCHITCV----NKAPTTCPV-----PPE--QTK 1121

  Fly  1126 SLLSLTQD----SVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVL--I 1184
            ..|.:...    :.:||.:.:|.....::  ||:|...||...|:..|:....|.:....|:  :
Human  1122 GPLGIDPQKGIGTAYEGHVRIPKPAGVKK--GWQRALAIVCDFKLFLYDIAEGKASQPSVVISQV 1184

  Fly  1185 LDL-SKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERP-- 1246
            :|: .:.:.|.||...|||.|..|:||.||::.     ||......::..:.:|....||:..  
Human  1185 IDMRDEEFSVSSVLASDVIHASRKDIPCIFRVT-----ASQLSASNNKCSILMLADTENEKNKWV 1244

  Fly  1247 GTI-----VHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRC----RNKIHKEHVDKHD 1302
            |.:     :.|.::|...:.::|........||....:..|..:.:|.    ...:...||.|.:
Human  1245 GVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDE 1309

  Fly  1303 PLAPCKLNHDPRSARDMLLLAATPEDQSLWV-------ARLLKRIQKSGYKAASYNNNSTDGSKI 1360
            .:..    .|.:....:.|:   |.||.:.|       .||.......|.:...|..:.|.|.:.
Human  1310 IIRV----GDNKKIHQIELI---PNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQT 1367

  Fly  1361 SPSQSTR 1367
            ..|...|
Human  1368 VTSGKVR 1374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RokNP_536796.2 STKc_ROCK 61..411 CDD:270747 182/356 (51%)
S_TKc 87..349 CDD:214567 141/265 (53%)
SbcC 484..1088 CDD:223496 143/695 (21%)
Rho_Binding 963..1027 CDD:286056 11/64 (17%)
PH_ROCK 1134..1250 CDD:269948 31/125 (25%)
C1 1254..1307 CDD:197519 9/56 (16%)
CDC42BPANP_001374479.1 STKc_MRCK_alpha 4..412 CDD:270773 199/410 (49%)
SbcC 432..>941 CDD:223496 125/583 (21%)
KELK 530..608 CDD:406277 21/91 (23%)
C1_MRCKalpha 1062..1121 CDD:410414 16/76 (21%)
PH_MRCK 1123..1257 CDD:269949 33/140 (24%)
CNH 1283..1547 CDD:395630 19/99 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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