DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Rock1

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001376168.1	Gene:	Rock1 / 81762	RGDID:	620424	Length:	1354	Species:	Rattus norvegicus

Alignment Length:	1393	Identity:	616/1393 - (44%)
Similarity:	864/1393 - (62%)	Gaps:	97/1393 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVE 85
            |...::..:|||.|..|.|||||.:.|||.|.|..:||:.|||:.:.::||....:|..|||..|
  Rat    10 RFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAE 74

  Fly    86 DFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQL 150
            |:..:|:||.|||||||||||||:.:|||||.||||||:||.|||||||||.|||.|||.|:|||
  Rat    75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 139

  Fly   151 HFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNM 215
            .:||||.:||||||::|||||:|:||.:||:|||||.|||.|||||||.||:|||:|||||||||
  Rat   140 FYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNM 204

  Fly   216 LLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLY 280
            |||..||||||||||||:|...|.|....|||||||||||||:|||.|..|||||||||||:|||
  Rat   205 LLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 269

  Fly   281 EMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKA 345
            |||.|:||||||||||||.|||:|||||:||.:.:||::||.||.||||||..||||.|:|:||.
  Rat   270 EMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKR 334

  Fly   346 HPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTY 410
            |.||:||.|:::.:|::|.||||:||||.||.||:|:|.|:..||.||:||.|.||.|||:||||
  Rat   335 HLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY 399

  Fly   411 TGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALE 475
            ..:.:.|.|         ||.:.:.::||     .:...:.|....:.:||..|..|....:.:|
  Rat   400 YSNRRYLPS---------ANPSENRSSSN-----VDKNVQESLQKTIYKLEEQLHNEMQLKDEME 450

  Fly   476 QQDAGLRQQIELITK-------REAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEAL 533
            |:......:::.|.|       :...|:...|:.||:..|.||......:|||||.|.|:..|..
  Rat   451 QKCRTSNIKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENE 515

  Fly   534 LVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEE 598
            :...:..||:.:|........|:|:..|:|||.|.....:||::...:|:|.:.|:..:|...|.
  Rat   516 VSTLKDQLEDLRKASQSSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSVSQLES 580

  Fly   599 KVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIERTMCRE 663
            ..|::.:....|:..|.:..::..:|||::..|:..|....||..:.:.::.:|..:::......
  Rat   581 LNRELQERNRMLENSKSQADKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNL 645

  Fly   664 QKAQEDNRALLEKISDLEK----AHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANLQEV 724
            ::.:.:.:...:.::..||    ....|:::||:.|.|.:|||..|:.| |:||..:.: :::|.
  Rat   646 ERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSIQQRLEQEVNEHKVT-KARLTDKHQ-SIEEA 708

  Fly   725 KA-----LQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQ 784
            |:     ::.||.||:.||.||:....|.|:|.|||.||.:|.|.:|:.|.....:..:.|.:|.
  Rat   709 KSVAMCEMEKKLKEEREAREKAENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERLEDAVKSLT 773

  Fly   785 SQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALAN 849
            .||:||.:||..|.|||...:.|..:|:..|.|:::|::|..||||..|.:|.||...:......
  Rat   774 LQLEQESNKRILLQSELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQ 838

  Fly   850 NRELQAQLEAEQCFSRLYKTQANENREE----SAERLSKIEDLEEERVSLKHQVQVAVARADSEA 910
            .||||.||||||.||.|||||..|.:||    :.|.|.||::|:.|:.:|..|:.:|..:|:||.
  Rat   839 MRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQ 903

  Fly   911 LARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYED 975
            |||.|.||...:|.:|.       |....::|.||..|:..::.|:||.|.|.|.:.....|.|:
  Rat   904 LARGILEEQYFELTQES-------KKAASRNRQEITDKDHTVSRLEEANNALTKDIELLRKENEE 961

  Fly   976 LVQQHKKQQEELALMRSSKDEEITKL---LDK-CKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNK 1036
            |.::.:..:||..|   .|:|||:.|   .:| ...|..||..|||||||:|||:|..:.::|
  Rat   962 LNERMRTAEEEYKL---KKEEEISNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKK-- 1021

  Fly  1037 ARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ----DLQQLCAEEQQLKQKMVMEIDCKAT 1097
             .:|.:|||||||.|:||.||:|||:||||:::|||    |:|....||...:.::.|::..|.:
  Rat  1022 -ANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKES 1085

  Fly  1098 EIENLQSKL------NETASLSSAD----NDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGH 1152
            :||.|::||      ...||..|||    |.||             |..||||||||:.|.:| :
  Rat  1086 DIEQLRAKLLDLSDSTSVASFPSADETDGNLPE-------------SRIEGWLSVPNRGNIKR-Y 1136

  Fly  1153 GWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLY 1217
            |||:|||:|||:|::|||.:.||..::.: ::||:.|::|||.||||||.||:.:|||:|||:||
  Rat  1137 GWKKQYVVVSSKKMLFYNDEQDKEQSSPS-MVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY 1200

  Fly  1218 AGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPA 1282
            |.||...:..|...:.        ..|:.....||||||:...||.|..||.|.|||||:||||.
  Rat  1201 ANEGECRKDIEVEPVQ--------QGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPP 1257

  Fly  1283 AYECKRCRNKIHKEHVD-KHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQK---S 1343
            |.||:||..|.|::|:| |.|.::|||:::|..|||||||||.:.::|..||..|:|:|.|   |
  Rat  1258 ALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPS 1322

  Fly  1344 GYKAASYNNNSTDGSKISPSQSTRSSYK 1371
            |:..||....||   :.:.:||.|...|
  Rat  1323 GFVRASPRTLST---RSTANQSFRKVVK 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	241/349 (69%)
		S_TKc	87..349	CDD:214567	193/261 (74%)
		SbcC	484..1088	CDD:223496	213/631 (34%)
		Rho_Binding	963..1027	CDD:286056	26/67 (39%)
		PH_ROCK	1134..1250	CDD:269948	53/115 (46%)
		C1	1254..1307	CDD:197519	29/53 (55%)
Rock1	NP_001376168.1	STKc_ROCK1	2..406	CDD:270772	260/395 (66%)
		Interaction with FHOD1. /evidence=ECO:0000250	368..727		99/374 (26%)
		SMC_prok_B	426..>1097	CDD:274008	227/685 (33%)
		HR1_ROCK1	489..554	CDD:212029	21/64 (33%)
		SHROOM3 binding. /evidence=ECO:0000250\|UniProtKB:Q13464	707..946		96/245 (39%)
		ROCK_SBD	836..913	CDD:409019	38/76 (50%)
		RHOA binding. /evidence=ECO:0000250	998..1010		9/11 (82%)
		PH_ROCK	1119..1225	CDD:269948	53/115 (46%)
		C1_ROCK1	1222..1290	CDD:410424	36/67 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336831
Domainoid	1	1.000	412	1.000	Domainoid score	I658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1074	1.000	Inparanoid score	I232
OMA	1	1.010	-	-		QHG46537
OrthoDB	1	1.010	-	-		D36370at33208
OrthoFinder	1	1.000	-	-		FOG0001986
OrthoInspector	1	1.000	-	-		otm46140
orthoMCL	1	0.900	-	-		OOG6_104177
Panther	1	1.100	-	-	LDO	PTHR22988
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1475
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910