DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Stk38l

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001076805.1	Gene:	Stk38l / 691337	RGDID:	1564793	Length:	464	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	165/436 - (37%)
Similarity:	242/436 - (55%)	Gaps:	75/436 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLR 81
            ||..|...||..|.:       :.|.|         :.:.|||    .|:|.|.... :::.:.|
  Rat    41 ERETRQKKLEVAMEE-------EGLAD---------EEKKLRR----SQHARKETEF-LRLKRTR 84

  Fly    82 MNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEW 146
            :.::||..:|:||.||||||:||:.|.:..:||||.|.|.:|:::...|....||.|:..|:..|
  Rat    85 LGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAW 149

  Fly   147 IVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD-IPEKWAIFYTMEVVLALDTIHNMGFVHRDV 210
            :|::.::|||.:.||::|:|:||||:::|:...| :.|:...||..|.|||:|.||.:||:|||:
  Rat   150 VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDI 214

  Fly   211 KPDNMLLDSYGHLKLADFGTC-------------------------MRMGA---------NGQVV 241
            ||||:|||:.||:||:|||.|                         ..|.:         |.:.:
  Rat   215 KPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQL 279

  Fly   242 SSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKN 306
            :.:.|||||||:|||....|    |.:.|||||:|:.:||||.|..||.:::...||.|:|..|.
  Rat   280 AYSTVGTPDYIAPEVFMQTG----YNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMSWKE 340

  Fly   307 SLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVP-EL 370
            :|:|||||.:||:||.||..|.||...|:|..|:|:||.||||....|.  :|||. |..:| |:
  Rat   341 TLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFFEGVDWG--HIRER-PAAIPIEI 402

  Fly   371 SSDDDTRNFEDIERDEKPEE--VFPVPK----GFDGNHLPFIGFTY 410
            .|.|||.||:|.     ||.  :.|||.    .:......|:.:||
  Rat   403 RSIDDTSNFDDF-----PESDILQPVPNTTEPDYKSKDWVFLNYTY 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	154/392 (39%)
		S_TKc	87..349	CDD:214567	125/296 (42%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
Stk38l	NP_001076805.1	STKc_NDR2	87..452	CDD:270776	150/369 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920