DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rok and RPS6KA3

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_011543857.1	Gene:	RPS6KA3 / 6197	HGNCID:	10432	Length:	746	Species:	Homo sapiens

Alignment Length:	362	Identity:	125/362 - (34%)
Similarity:	186/362 - (51%)	Gaps:	39/362 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FHFIKLIGAGAFGEVQLVRHKSSS---QVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIV 148
            |..:|::|.|:||:|.||:..|.|   |:||||.|.|..:..| |......||.|:...|..:||
Human    68 FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVR-DRVRTKMERDILVEVNHPFIV 131

  Fly   149 QLHFAFQDAKYLYMVMDFMPGGDIVS-LMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKP 212
            :||:|||....||:::||:.|||:.: |..:....|:...||..|:.||||.:|::|.::||:||
Human   132 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKP 196

  Fly   213 DNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGI 277
            :|:|||..||:||.||| ..:...:.:..:.:..||.:|::|||:..:|    :.:..||||.|:
Human   197 ENILLDEEGHIKLTDFG-LSKESIDHEKKAYSFCGTVEYMAPEVVNRRG----HTQSADWWSFGV 256

  Fly   278 FLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIR-AFLTDRTQRL------ 335
            .::|||.|..||.......|...|:  |..|..|.  .:|.:|::|:| .|..:...||
Human   257 LMFEMLTGTLPFQGKDRKETMTMIL--KAKLGMPQ--FLSPEAQSLLRMLFKRNPANRLVNPFLI 317

  Fly   336 --GRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGF 398
              |..|:|:||.|.||....|:....||..||..|.....:||..|:       ||.....||..
Human   318 GAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD-------PEFTAKTPKDS 375

  Fly   399 DG------NHLPFIGFTY---TGDYQLLSSDTVDAES 426
            .|      .|..|.||::   |.|.:..:..||...|
Human   376 PGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	120/345 (35%)
		S_TKc	87..349	CDD:214567	100/274 (36%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	100/274 (36%)
		STKc_RSK_N	72..394	CDD:270734	119/338 (35%)
		STKc_RSK2_C	408..737	CDD:271078	2/5 (40%)
		Pkinase	428..685	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910