DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Tacc2

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006508127.1	Gene:	Tacc2 / 57752	MGIID:	1928899	Length:	2928	Species:	Mus musculus

Alignment Length:	681	Identity:	142/681 - (20%)
Similarity:	262/681 - (38%)	Gaps:	163/681 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 SEYEKDLALRQHNYKVAMQKVEQEIELRK---KTEALLVETQRNLENEQKTRARDLNINDKVVSL 561
            |:.::...|.|.:|.......|:.::..|   ||.:...::..:.|....|...|.:      .|
Mouse  2303 SKMQESPKLSQQSYNFDPDACEESLDPFKASSKTPSSPSKSPASFEIPASTTEADGD------GL 2361

  Fly   562 EKQLLEMEQSYKTETENTQKLKKHNAELD------------------FTV--KSQEEKV----RD 602
            .|...:.:...||:|...:|..|.:...|                  .||  .:.|||:    :.
Mouse  2362 NKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPEAPSAISTVVHATDEEKLAVTSQK 2426

  Fly   603 MVDMIDTLQKHKEELGQENAELQALVVQEK-NLRSQLKEMHKEAENKMQTLINDIERTMCREQKA 666
            ...|...|...|::..|. ::|...|.:.| |..|:.|::..:.:..:.     :|.|:.|.|:|
Mouse  2427 WTCMTVDLDADKQDFPQP-SDLSNFVNETKFNSPSEGKQLGGQPDPHLA-----LENTVPRGQRA 2485

  Fly   667 QE-------DNRALLEKISDLEKAHAGL--DFELKAAQGRYQQEVKAHQETEKSRLVSREE---- 718
            ::       |.|...| |..:||..:.|  |.:....|..|.......:...||..|...:
Mouse  2486 RKGTCQPELDYRNSYE-IEYMEKLGSSLPQDDDTPKKQALYLMFDTPQESPVKSPPVRMSDSPTP 2549

  Fly   719 ---ANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKV 780
               ::.::.:||.:...:.:....:....|||     .:|.|..:..|..|:.:......|:.::
Mouse  2550 CSGSSFEDTEALVNAATKLQHPVARGLPSSQE-----PLLQVPEKPSQKELEAMALGTPAEAIEI 2609

  Fly   781 AALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRE------------NQLQKELSTQREAKRRFE 833
            .|.:...    :..:.|||.|:..:|....|...|            .:||:||..   |..|.|
Mouse  2610 TAPEGAF----ASADTLLSRLAHPASLCGALGYLEPDLAEKNPPVFAQKLQEELEF---AVMRIE 2667

  Fly   834 EDLTQLKSTHHEALANNRELQAQLEAEQ----------CFSRLYKTQA--------NENREESAE 880
                .||.....|||:......:.||..          .:||:..|:.        .:...:||.
Mouse  2668 ----ALKLARQIALASRSRQDTKREAAHPPDVSISKTALYSRIGSTEVEKPPGLLFQQPDLDSAL 2728

  Fly   881 RLSKIEDLEEERVSLKHQVQVAVARADSEALARSIA--EETVA-------DLEKEKTIKELELKD 936
            ::::.|.:.:||...:.:.:...:|.:...:.:.:|  |:|:|       |.::||:|....::.
Mouse  2729 QVARAEVIAKEREVSEWRDKYEESRREVVEMRKIVAEYEKTIAQMIGKPEDEQREKSISHQTVQQ 2793

  Fly   937 FVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKL 1001
            .|::       ||.|||.|...|..|           .||.::::|.:|.|...|  |:||:.|
Mouse  2794 LVLE-------KEQALADLNSVEKSL-----------ADLFRRYEKMKEVLEGFR--KNEEVLK- 2837

  Fly  1002 LDKCKNEVL------------LKQVAVNKLAEVMNRRDSDLPKQKNKARS-----TAELRKKEKE 1049
              ||..|.|            ||..|..||    :|.::::.:.:.||:.     .|.|||::..
Mouse  2838 --KCAQEYLSRVKKEEQRYQALKVHAEEKL----DRANAEIAQVRGKAQQEQAAYQASLRKEQLR 2896

  Fly  1050 MRRLQQELSQERDKFNQLLLKHQDLQQLCAE 1080
            :..|::.|.|:..:.       ::|.::|.|
Mouse  2897 VDALERTLEQKNKEI-------EELTKICDE 2920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747
		S_TKc	87..349	CDD:214567
		SbcC	484..1088	CDD:223496	142/681 (21%)
		Rho_Binding	963..1027	CDD:286056	20/75 (27%)
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
Tacc2	XP_006508127.1	PHA03307	1748..>2120	CDD:223039
		PRK13335	2053..>2164	CDD:139494
		TACC	2719..2922	CDD:368238	55/236 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000